Chronic Airway Inflammation
Mostrando 1-12 de 76 artigos, teses e dissertações.
-
1. Petiveria alliacea, a plant used in Afro-Brazilian smoke rituals, triggers pulmonary inflammation in rats
Abstract Petiveria alliacea L., Phytolaccaceae, a plant used in Afro-Brazilian religious smoke rituals is reported to have "harmonic properties" (anxiolytic effect) by ethnobotanical survey. In the present work, we analyzed the chemical composition of volatiles produced by leaves of P. alliacea, using headspace gas chromatography/mass spectrometry and its po
Rev. bras. farmacogn.. Publicado em: 09/12/2019
-
2. Ability of two new thiazolidinediones to downregulate proinflammatory cytokines in peripheral blood mononuclear cells from children with asthma
Allergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidi
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
-
3. Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice
Asthma is a chronic allergic disease characterized by airway inflammation, airway hyper-responsiveness (AHR), and mucus hypersecretion. T-lymphocytes are involved in the pathogenesis of asthma, mediating airway inflammatory reactions by secreting cytokines. The phosphoinositide 3-kinase (PI3K) and Notch signaling pathways are associated with T cell signaling
Braz J Med Biol Res. Publicado em: 20/07/2017
-
4. Estudo da ativação eosinofílica e de matriz extracelular de tecido pulmonar periférico em cobaias com inflamação alérgica pulmonar: efeitos do tratamento com dexametasona e antagonista do receptor do cisteinil-leucotrieno D4
Aims: Compare the effects of montelukast or dexamethasone treatments on eosinophilic recruitment, eotaxin, RANTES, fibronectin, IGF-I and NF-B positive cells of distal lung parenchyma and also in airway walls of guinea pigs (GP) with chronic allergic inflammation. Methods: GP were inhaled with ovalbumin (OVA group-2x/week/4weeks). After 4th inhalation, GP we
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
-
5. Tratamento com inibidor da Rho quinase em cobaias com inflamação alérgica crônica: modulação da inflamação eosinofílica, da expressão de citocinas inflamatórias, da matriz extracelular, do estresse oxidativo e da reatividade de vias aéreas / Treatment with Rho-kinase inhibitor in guinea pigs with chronic allergic inflammation: modulation of eosinophilic inflammation, expression of inflammatory cytokines, extracellular matrix, oxidative stress and airway responsiveness
INTRODUÇÃO: Vários estudos têm mostrado a importância da Rho quinase na modulação da contração do músculo liso, hiperresponsividade das vias aéreas e inflamação. Entretanto, os efeitos do tratamento crônico com um inibidor específico desta via não haviam sido previamente investigados. MÉTODOS: No presente estudo, foram avaliados os efeitos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/04/2012
-
6. Influência da variabilidade genética sobre biomarcadores de dano oxidativo e não oxidativo em pacientes com doença pulmonar obstrutiva crônica (DPOC)
Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive condition of poor reversibility that is characterized by airflow limitation associated with an abnormal inflammatory response of the lungs. Its development and progression are related to increased oxidative stress, which is an important pathogenic component of airway inflammation in this di
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
7. Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling
Chronic obstructive pulmonary disease (COPD) is associated with inflammatory cell reactions, tissue destruction and lung remodeling. Many signaling pathways for these phenomena are still to be identified. We developed a mouse model of COPD to evaluate some pathophysiological mechanisms acting during the initial stage of the disease. Forty-seven 6- to 8-week-
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-05
-
8. Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation
We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trai
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-04
-
9. Efeito do condicionamento físico aeróbico de moderada intensidade na inflamação pulmonar alérgica crônica e na hiperresponsividade brônquica à metacolina em cobaias sensibilizadas / Effects of aerobic physical training with moderate intensity on chronic airway inflammation and bronchial hyperresponsivity to a methacoline in sensitized guinea pig
O treinamento físico (TF) melhora a resposta imune de indivíduos saudáveis e traz benefícios para o paciente asmático, mas seu papel na resposta alérgica é desconhecido. Objetivo: Avaliar o papel do TF de moderada intensidade na inflamação pulmonar alérgica crônica. Métodos: 54 cobaias, divididas em 4 grupos: grupo controle (C) (não sensibilizad
Publicado em: 2009
-
10. Asthma: where is it going?
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness and inflammation are still debated. The first mechanism identified as important for asthma was bronchial hy
Brazilian Journal of Medical and Biological Research. Publicado em: 20/08/2008
-
11. Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease
Little is known about airway inflammatory markers in chronic obstructive pulmonary disease (COPD). The objective of the present study was to identify and try to correlate pulmonary and peripheral blood inflammatory markers in COPD. In a cross-sectional study on patients with stable COPD, induced sputum and blood samples were collected for the determination o
Brazilian Journal of Medical and Biological Research. Publicado em: 20/02/2008
-
12. Estudo da mecânica oscilatória e do remodelamento de tecido pulmonar periférico em modelo de inflamação alérgica em cobaias: efeitos da inibição da óxido nítrico sintase induzida / Oscillatory mechanics and periphery lung tissue remodeling study in an allergic inflammation model in guinea pigs: effects of inducible nitric oxide synthase inhibition
INTRODUCTION: The importance of lung parenchyma in functional asthma impairment has been recently addressed. Although the inducible nitric oxide synthase (iNOS) activation amplifies chronic inflammation-induced airway responsiveness and remodeling, its effect on lung parenchyma has not been previously investigated. OBJECTIVE: To evaluate the influence of iNO
Publicado em: 2008