Chronic Constriction Injury
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats
Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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2. Treatment with ascorbic acid and α-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain
Vitamin E (vit. E) and vitamin C (vit. C) are antioxidants that inhibit nociception. The effect of these vitamins on oxidative-stress markers in the spinal cord of rats with chronic constriction injury (CCI) of the sciatic nerve is unknown. This study investigated the effect of intraperitoneal administration of vit. E (15 mg·kg-1·day-1) and vit. C (30 mg·
Braz J Med Biol Res. Publicado em: 01/03/2018
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3. Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain
N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Thus, our study asse
Braz J Med Biol Res. Publicado em: 19/10/2017
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4. Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine
Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role in nerve injury-related pain. We tested the hypothesis that
Braz J Med Biol Res. Publicado em: 07/08/2017
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5. N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain
We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain. The sciatic functional index (SFI) was also m
Braz J Med Biol Res. Publicado em: 16/02/2017
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6. Ameliorative potential of Ocimum sanctum in chronic constriction injury-induced neuropathic pain in rats
O presente estudo foi delineado para avaliar-se o potencial efeito analgésico de extratos de Ocimum sanctum e uma fração enriquecida em saponinas na dor neuropática induzida pela lesão por constrição crônica de nervos periféricos em ratos. A lesão foi induzida pela colocação de quatro ligaduras apostas ao nervo ciático, proximalmente à sua trif
An. Acad. Bras. Ciênc.. Publicado em: 10/02/2015
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7. Attenuation of oxidative stress, inflammation and apoptosis by ethanolic and aqueous extracts of Crocus sativus L. stigma after chronic constriction injury of rats
Em nosso estudo anterior, os extratos etanólico e aquoso de Crocus sativus provocaram efeitos antinociceptivos no modelo de lesão por constrição crônica (CCI) da dor neuropática. Neste estudo, exploramos os efeitos anti-inflamatório, anti-oxidante e anti-apoptótico de tais extratos em animais CCI. Um total de 72 animais foi dividido em ratos CCI trat
An. Acad. Bras. Ciênc.. Publicado em: 09/12/2014
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8. Ameliorative potential of Vernonia cinerea on chronic constriction injury of sciatic nerve induced neuropathic pain in rats
O objetivo do presente estudo é investigar o potencial benéfico do extrato etanólico da planta inteira de Vernonia cinerea sobre a dor neuropática induzida pela lesão por constrição crônica (CCI) do nervo ciático em ratos. Parâmetros comportamentais, tais como uma placa quente, uma gota de acetona, a pressão na pata, teste do filamento de Von Frey
An. Acad. Bras. Ciênc.. Publicado em: 09/09/2014
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9. An improved experimental model for peripheral neuropathy in rats
A modification of the Bennett and Xie chronic constriction injury model of peripheral painful neuropathy was developed in rats. Under tribromoethanol anesthesia, a single ligature with 100% cotton glace thread was placed around the right sciatic nerve proximal to its trifurcation. The change in the hind paw reflex threshold after mechanical stimulation obser
Braz J Med Biol Res. Publicado em: 15/03/2013
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10. Mobilização neural em rato Wistar reverte comportamento e mudanças celulares que caracterizam a dor neuropática. / Neural mobilization reverses behavioral and cellular changes that characterize neuropathic pain in rats Wistar.
The Neural Mobilization technique is a noninvasive method that has proved clinically effective in reducing pain sensitivity and consequently in improving quality of life after neuropathic pain. The present study examined the effects of Neural Mobilization (MOB) on pain sensitivity induced by chronic constriction injury (CCI) in rats. The CCI was performed on
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012
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11. Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats
O presente trabalho visou investigar o papel do extrato etanólico de folhas de Butea monosperma no alívio da dor neuropática pela injúria de constrição crônica (CCI) do nervo ciático induzida em ratos. Placa quente, gota de acetona, pressão na pata, testes de imersão de pelo e cauda de Von Frey foram utilizados para acessar o grau de hiperalgesia t
An. Acad. Bras. Ciênc.. Publicado em: 25/09/2012
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12. Evaluation of possible mechanisms involved in the antinociceptive effect of the C-terminus of murine S100A9 on experimental neuropathic pain: an experimental approach / Avaliação de possíveis mecanismos envolvidos no efeito antinociceptivo do C-terminal da S100A9 murina sobre a dor neuropática experimental
O peptídeo sintético idêntico ao C-terminal da proteína S100A9 murina (pS100A9m) possui efeito antinociceptivo em diferentes modelos de dor inflamatória aguda. No presente estudo, o efeito do pS100A9m foi avaliado sobre a dor neuropática induzida pela constrição crônica (CCI) do nervo ciático em ratos. Ainda, foram investigados os possíveis mecani
Publicado em: 2008