Chylomicrons Metabolism
Mostrando 1-12 de 32 artigos, teses e dissertações.
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1. Metabolismo de quilomícrons e aterosclerose subclínica em portadores de hipercolesterolemia familiar heterozigótica / Chylomicrons metabolism and subclinical atherosclerosis in patients with heterozygous familial hypercholesterolemia
A hipercolesterolemia familiar (HF) é uma doença caracterizada por elevadas concentrações do colesterol das lipoproteínas de baixa densidade (LDL) e doença coronariana (DAC) prematura. Os remanescentes de quilomícrons são removidos principalmente pelo seu receptor específico (RLP), mas também pelo receptor da LDL. Este último encontra-se defeituos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/09/2011
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2. Responses of postprandial lipemia in young men, after continuous and intermittent exercise / Respostas da lipemia pós-prandial em homens jovens, após exercício contínuo e intermitente
Background: Increased plasma triglyceride-rich lipoprotein (chylomicrons, VLDL and LDL) concentration, as well as the delay in their removal, has been associated with coronary artery diseases (CVD). The postprandial lipaemia is related to peripheral vascular changes, stimulated by inflammatory markers and enhanced by oxidative metabolism of low density lipop
Publicado em: 2010
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3. Chylomicron metabolism and lipid reception capacity of high density lipoprotein in metabolic syndrome (MetS) and type 2 diabetes mellitus (DM2) / Metabolismo dos quilomícrons e capacidade da lipoproteína de alta densidade (HDL) de receber lípides na síndrome metabólica e no diabetes mellitus tipo 2
The main metabolic disturbances occurring as a result of type 2 diabetes mellitus (DM2) and Metabolic Syndrome (MetS) are alterations in the metabolism of lipids. It is therefore, important to better understand the aspects by which plasma lipoproteins are metabolized. The evaluation of chylomicron metabolism and lipid transfer of high density lipoprotein (HD
Publicado em: 2008
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4. Lipolysis of emulsion models of triglyceride-rich lipoproteins is altered in male patients with abdominal aorta aneurysm
Disorders of the lipid metabolism may play a role in the genesis of abdominal aorta aneurysm. The present study examined the intravascular catabolism of chylomicrons, the lipoproteins that carry the dietary lipids absorbed by the intestine in the circulation in patients with abdominal aorta aneurysm. Thirteen male patients (72 ± 5 years) with abdominal aort
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-03
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5. Avaliação do metabolismo de quilomícrons artificiais em pacientes obesas e não obesas, portadoras da síndrome dos ovários policísticos / Evaluation of artificial chylomicrons metabolism in obese and nonobese patients with polycystic ovary syndrome
Este estudo teve como objetivos avaliar o metabolismo de quilomícrons utilizando a metodologia da cinética plasmática de uma emulsão de quilomícrons artificiais em pacientes com síndrome dos ovários policísticos (SOP), assim como o impacto da obesidade nesta cinética. Foram estudadas 43 mulheres adultas jovens, subdivididas em 4 grupos, sendo 8 paci
Publicado em: 2007
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6. Regulation of serum apolipoprotein E metabolism: role of chylomicron metabolism.
The mechanism by which high-fat, high-cholesterol diets lower serum apolipoprotein E (apoE) concentration was studied in rats by feeding a single high-fat, high-cholesterol meal and by intravenously infusing chylomicrons containing low and high amounts of cholesterol. Serum apoE concentrations were unchanged 9 hours after an olive oil meal but were decreased
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7. Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons
The metabolism of chylomicrons doubly labeled with cholesterol-3H and triglyceride-14C was studied in unanesthetized rats which were absorbing a fatty test meal. 10 min after intravenous injection, 80% of chylomicron cholesteryl ester, but only 20% of chylomicron triglyceride, was found in the liver. Treatment of recipient rats with puromycin to block hepati
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8. METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS*
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9. Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.
To investigate the role of apoE in hepatic uptake of chylomicron remnants, we studied chylomicron metabolism in transgenic mice overexpressing apoE in the liver. Plasma clearance of injected 125I-labeled human chylomicrons was fivefold faster in transgenic mice than in controls. Immunohistochemistry demonstrated that apoE was specifically localized at the ba
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10. Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat.
The metabolism of intravenously injected large and small chylomicrons from intestinal lymph and of very low density lipoproteins from blood plasma was studied in functionally eviscerated "supradiaphragmetic" rats. For studies with lymph lipoproteins, recipient animals were injected with 4-amino-pyrazolopyrimidine 18 h before injection of lipoprotein to preve
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11. A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.
The formation of chylomicrons by the intestine is important for the absorption of dietary fats and fat-soluble vitamins (e.g., retinol, alpha-tocopherol). Apo B plays an essential structural role in the formation of chylomicrons in the intestine as well as the VLDL in the liver. We have developed genetically modified mice that express apo B in the liver but
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12. Interchange of Apolipoproteins between Chylomicrons and High Density Lipoproteins during Alimentary Lipemia in Man
Apolipoproteins of the “C” group in human blood plasma, which contain the activator of the lipoprotein lipase-substrate interaction, were found to be transferred specifically from serum to phospholipid-stabilized fat emulsion. Content and distribution of apoprotein activator were measured in healthy men in the postabsorptive state and 4 h after ingestion