Citotoxic
Mostrando 1-12 de 43 artigos, teses e dissertações.
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1. Atividade antimicrobiana e citotoxicidade in vitro do óleo essencial de Tagetes minuta L. visando à aplicação no controle da mastite bovina
RESUMO O objetivo deste estudo foi avaliar a atividade antimicrobiana in vitro do óleo essencial de Tagetes minuta L. contra Staphylococcus aureus e Escherichia coli e a citotoxicidade sobre células epiteliais da glândula mamária bovina (MAC-T), visando a seu uso no tratamento da mastite bovina. A análise qualitativa do óleo revelou cis-tagetona (24,24
Arq. Bras. Med. Vet. Zootec.. Publicado em: 10/10/2019
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2. PHENOLIC DERIVATIVES AND ANTIOXIDANT ACTIVITY OF POLAR EXTRACTS FROM Bauhinia pulchella
A tea made with the leaves or stem bark of Bauhinia pulchella Benth (Fabaceae) is used in the treatment of diabetes. Ethanol (EEF) and aqueous (EAF) extracts were obtained from the leaves and the antioxidant and citotoxic activities were tested, as well as quantify the content of flavonoids and phenolic compounds (TPC). EEF and EAF showed similar profiles by
Quím. Nova. Publicado em: 2018-04
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3. Investigação da reação de Morita-Baylis-Hillman em reator de micro-ondas usando aldeídos aromáticos e isatina como eletrófilos: avaliação da atividade citotóxica em linhagem de células de leucemia promielocítica humanas (HL-60). / Investigation of Morita-Baylis-Hillman Reaction on Microwave Reactor using Aromatic Aldehydes and Isatin as Eletrophiles: Evaluation of Cytotoxic Activity in cell line human promyelocytic leukemia (HL-60).
In this work, we describe the investigation of the Morita-Baylis-Hillman reaction in microwave reactor, under closed vessel conditions to prepare 40 adducts, six novel, using 30 aromatic aldehydes and isatin as electrophiles and acrylonitrile (62a) , methyl acrylate (2), hydroxyethyl acrylate (62b), 2,2-dimethyl-1 ,3-dioxalyl acrylate (62c) and 2,3-dihydroxy
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/11/2012
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4. Citotoxic activity evaluation of essential oils and nanoemulsions of Drimys angustifolia and D. brasiliensis on human glioblastoma (U-138 MG) and human bladder carcinoma (T24) cell lines in vitro
The species Drimys angustifolia Miers and D. brasiliensis Miers, commonly known as "casca-de-anta", have in their leaves essential oils that can confer cytotoxic effects. In this study, we evaluated the citotoxic effects of the volatile oils from these two species. We also proposed a nanoemulsion formulation for each of the species and assessed the in vitro
Rev. bras. farmacogn.. Publicado em: 22/11/2012
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5. Produção, isolamento e identificação de metabólito com atividade citotóxica de cultura de Streptomyces carpaticus / Production, isolation and identification of citotoxic activity metabolite of streptomyces carpaticus culture
This study addresses the production, isolation and identification of the substance present in culture broth of Streptomyces carpaticus which showed high biological activity against human tumor cell lines HL-60 (promyelocytic leukemia), MDA-MB 435 (breast carcinoma ), HCT-8 (colon carcinoma), SF-295 (glioblastoma). Cultures of Streptomyces carpaticus in cultu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/09/2011
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6. Analysis of antimicrobial, cytotoxic and mutagenic potencial of extracts and substances obteined of diferente species of Piper / Análise do potencial antimicrobiano, citotóxico e mutagênico de extratos e substâncias obtidas de diferentes espécies de Piper
The infectious diseases are now one of the major causes of death in all over the world. The appearance of emerging infectious diseases and the problem of microbial resistance has driven the research for new antimicrobial agents. A thousand of years the medicinal plants has been used by your properties of healing. From this utilization scientific studies has
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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7. Síntese de novas amidas graxas a partir da aminólise de ésteres metílicos
Recent biochemical and pharmacological studies have led to the characterization of different fatty acid amides as a new family of biologically active lipids. Here, we describe the synthesis of new amides from C16:0, 18:0, 18:1 and 18:1, OH fatty acids (FFA) families with cyclic and acyclic amines and demonstrate for the first time that these compounds produc
Química Nova. Publicado em: 2010
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8. Estudo das propriedades citotÃxica da nor-β-lapachona e seu derivado nitrofenilamino em cÃlulas HL-60 / STUDY OF THE CITOTOXIC PROPERTIES THE NOR-β-LAPACHONE AND ITS NITROPHENYLAMINO DERIVATIVE IN HL-60 CELLS
O esqueleto quinona foi identificado como um importante grupo farmacofÃrico para atividade citotÃxica de vÃrios compostos utilizados na clÃnica, constituindo ainda uma das maiores classes de agentes anticÃncer. A β-lapachona à uma das quinonas mais estudadas nos Ãltimos anos. Suas aplicaÃÃes mais importantes estÃo relacionadas Ãs aÃÃes cont
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/07/2009
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9. Correlação entre os ensaios de citotoxicidade em Artemia salina Leach e atividade antineoplásica sobre linhagens de células tumorais para algumas classes de produtos naturais / Correlation between the citotoxicity assays in Artemia salina Leach and antineoplasic activity on tumoral cell lines for some natural products groups
The aim of this study was to correlate qualitative and quantitatively the lethal concentration needed for the citotoxic test on Artemia salina with the inhibitory concentration for the growth of tumoral cell lines using ten pure substances already known. Estimates for the year 2008 and also valid for the year 2009, in Brazil, show the occurrence of 466.730 n
Publicado em: 2009
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10. Biological activity of amides and analogs from Piper species and synthetic analogs / Atividade biológica de amidas e análogos de espécies de Piper e estudos biossintéticos
Six amides were isolated from Piper scutifolium and P. corcovadensis including piperovatine, piperlonguminine, isopiperlonguminine and corcovadine, the new scutifoliamide A and scutifoliamide B and also two aristolactams (piperolactam C and stigmalactam). From P. tuberculatum the amides piplartine and pellitorine and two esters, ethyl (E)-3,4,5-trimethoxycin
Publicado em: 2009
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11. Efeitos citotoxicos e genotoxicos no meristema radicular de Allium cepa exposta a agua do Rio Paraiba do Sul - estado de São Paulo - regiões de Tremembe e Aparecida / Citotoxic and genotoxic effects in the root meristem of Allium cepa exposed to the water of the Paraiba do Sul river - São Paulo state - regions of Tremembe and Aparecida
One of the main sources of pollution of fresh water ecosystems refers to the discharge of industrial and urban wastes. Untreated sewage is considered an important cause to the deterioration of water quality in developing countries. Environmental pollutants have caused a decrease in water quality, inducing harmful effects in organisms which are in direct or i
Publicado em: 2009
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12. Avaliao das atividades biolgicas de espcies do gnero Lychnophora (arnicas) e Estudo fitoqumico do extrato ativo de Lychnophora staavioides Mart. / Avaliao das atividades biolgicas de espcies do gnero Lychnophora (arnicas) e Estudo fitoqumico do extrato ativo de Lychnophora staavioides Mart.
Twenty-two extracts from five Lychnophora species and one Lychnophoriopsis species, traditionally used in Brazil as analgesic, antiinflammatory, and to treat bruise and rheumatism were examined for the inhibition of xanthine oxidase (XO), the antioxidant activity, the citotoxic activity and the phytochemical study of the chloroform extracts from Lychnophora
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/02/2008