Collagen Type V 2
Mostrando 1-12 de 63 artigos, teses e dissertações.
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1. Short-term renal and metabolic effects of low dose vildagliptin treatment added-on insulin therapy in non-proteinuric patients with type 2 diabetes: open-label randomized prospective study
ABSTRACT Objective The aim of this randomized comparative study was to assess renal and metabolic effects of vildagliptin in insulin-treated type 2 diabetes (T2DM) patients without overt chronic kidney disease. Subjects and methods We randomized 47 insulin-treated non-proteinuric patients with satisfactory controlled T2DM and estimated glomerular filtratio
Arch. Endocrinol. Metab.. Publicado em: 2020-08
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2. Anti-collagen type v: a marker of early systemic sclerosis?
Abstract Objective: To evaluate the frequency of anti-collagen type V in humans with early systemic sclerosis (SSc) compared to defined SSc patients and healthy controls, since collagen type V was shown to be overexpressed in early SSc patients’ skin and there is no data concerning the presence of this antibody in early stages of human SSc. Experimental s
Adv. rheumatol.. Publicado em: 29/07/2019
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3. Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom
Abstract Background: Lachesis muta rhombeata (Lmr) is the largest venomous snake in Latin America and its venom contains mainly enzymatic components, such as serine and metalloproteases, L-amino acid oxidase and phospholipases A2. Metalloproteases comprise a large group of zinc-dependent proteases that cleave basement membrane components such as fibronectin
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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4. Effect of hydroxyurea (HU) on gelatinization mechanism of type I collagen suspensions
ABSTRACT Mutant hemoglobins thermodynamic phase transitions (HbS, HbC, etc.) have been the causes of serious hemoglobinopathies that have been affecting mankind since the dawn of human race. HbS polymerization is the best known of these transitions and the original cause of sickle cell anemia. Hydroxyurea (HU, NH2CONHOH) is widely used as the main drug admin
Matéria (Rio J.). Publicado em: 06/12/2018
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5. Modeling pulmonary fibrosis by abnormal expression of telomerase/apoptosis/collagen V in experimental usual interstitial pneumonia
Limitations on tissue proliferation capacity determined by telomerase/apoptosis balance have been implicated in pathogenesis of idiopathic pulmonary fibrosis. In addition, collagen V shows promise as an inductor of apoptosis. We evaluated the quantitative relationship between the telomerase/apoptosis index, collagen V synthesis, and epithelial/fibroblast rep
Braz J Med Biol Res. Publicado em: 04/06/2014
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6. Estudo da interação endotélio-matriz extracelular no remodelamento da pele observado no modelo experimental de esclerodermia e na enfermidade espontânea humana / Study of endothelium-extracellular matrix interaction in skin remodeling observed in an experimental model of scleroderma and spontaneous human disease
Introdução: A imunização de coelhos saudáveis com colágeno do tipo V (COLV) reproduz as principais manifestações da esclerose sistêmica (ES), incluindo fibrose, vasculopatia e produção de autoanticorpos específicos da doença. Estudos preliminares mostraram que, tanto na derme de animais imunizados com COLV (COLV-IM), como na derme de pacientes c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/10/2012
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7. Estudo da participação do colágeno V no câncer de pulmão, especificamente no carcinoma não de pequenas células / Study of the involvement of collagen V in lung cancer specifically in non-small cell carcinoma
O colágeno V vem emergindo como um potente indutor de morte celular (apoptose) via caspase. Nosso objetivo, neste estudo, foi examinar a interface entre o colágeno dos tipos I, III e V, apoptose tumoral e endotelial, angiogênese e células imunes, assim como o impacto desses fatores no prognóstico de pacientes com carcinomas não de pequenas células (CN
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/09/2011
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8. The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis
Searching for effective Smad3 gene-based gene therapies for hepatic fibrosis, we constructed siRNA expression plasmids targeting the rat Smad3 gene and then delivered these plasmids into hepatic stellate cells (HSCs). The effect of siRNAs on the mRNA levels of Smad2, Smad3, Smad4, and collagens I-α1, III-α1 and IV-α1 (Colα1, Col3α1, Col4α1, respectivel
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-02
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9. Effect of gallium-arsenide laser, gallium-aluminum-arsenide laser and healing ointment on cutaneous wound healing in Wistar rats
This study determined the effects of gallium-aluminum-arsenide laser (GaAlAs), gallium-arsenide laser (GaAs) and Dersani® healing ointment on skin wounds in Wistar rats. The parameters analyzed were: type I and III collagen fiber concentrations as well as the rate of wound closure. Five wounds, 12 mm in diameter, were made on the animals’ backs. The depth
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-04
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10. Collagen content, but not the ratios of collagen type III/I mRNAs, differs among hypertensive, alcoholic, and idiopathic dilated cardiomyopathy
Cardiac interstitial fibrosis may contribute to ventricular dysfunction and the prognosis of patients with dilated cardiomyopathy. The objective of the present study was to determine if total myocardial collagen content and collagen type III/I (III/I ratio) mRNAs differ in hypertensive, alcoholic, and idiopathic dilated cardiomyopathy subjects. Echocardiogra
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
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11. Humoral immune response characterization of the type V collagen induced scleroderma experimental model / Caracterização da resposta imune em modelo experimental de esclerodermia induzida por colágeno tipo V
Experimental models for human diseases are of utmost importance, since they allow the study of their pathogenesis and therapeutic approach. In this group we can include the experimental model of collagen V-induced scleroderma, in rabbits, with histological alterations (skin, lung and kidney) similar to those observed in humans. Auto-immune diseases have an u
Publicado em: 2005
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12. 150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen.
We have previously shown that von Willebrand factor (vWF), a glycoprotein which plays a critical role in the adhesion of platelets to injured blood vessels, is present within vascular subendothelium. We investigated the identity of the subendothelial binding site(s) for vWF by examining vWF binding to subendothelial constituents and solubilized a 150-kD prot