Compartmental Models
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Biodistribution, pharmacokinetics and toxicity of a Vasconcellea cundinamarcensis proteinase fraction with pharmacological activity
Abstract Prior studies demonstrate that a proteinase fraction from Vasconcellea cundinamarcensis V.M. Badillo, Caricaceae, exhibits wound healing activity in gastric and cutaneous models and antitumoral/antimetastatic effects. Here, we present the toxicity, pharmacokinetics and biodistribution data for this proteinase fraction following a single dose into Sw
Rev. bras. farmacogn.. Publicado em: 2016-02
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2. Desenvolvimento de um código computacional de apoio ao cálculo de dose interna para radionuclídeos de interesse do IPEN / Development of a computational code for the internal doses assessment of the main radionuclides of occupational exposure at IPEN
A dose resultante da contaminação interna pode ser estimada por meio de modelos biocinéticos em conjunto com os resultados experimentais obtidos de medidas de bioanálise e do conhecimento do momento da incorporação. Os modelos biocinéticos são representados por um conjunto de compartimentos que expressam o transporte, a retenção e a eliminação do
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2011
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3. A computer simulation study of motoneuron models with active dendrites in response to synaptic inputs. / Estudo por simulação computacional de modelos de motoneurônios com dendrito ativo em resposta a entradas sinápticas.
Mathematical models of motoneurons have been developed as an aid to the understanding of phenomena involving the neuromuscular system, but most of these models have been based on the hypothesis of a passive dendritic tree. This holds for anesthetized animals but not necessarily during normal motor behavior of the intact animal. Experiments with decerebrate a
Publicado em: 2010
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4. Parameter estimation of compartmental models for positron emission tomography. / Estimação de parâmetros de modelos compartimentais para tomografia por emissão de pósitrons.
O presente trabalho possui como metas o estudo, simulação, identificação de parâmetros e comparação estatística de modelos compartimentais utilizados em tomografia por emissão de pósitrons (PET). Para tanto, propõe-se utilizar a metodologia de equações de sensibilidade e o método de Levenberg-Marquardt para a tarefa de estimação de parâmetro
Publicado em: 2010
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5. Bayesian and maximum likelihood estimation of SIR stochastic models / Estimação bayesiana e por maxima verossimilhança de modelos SIR estocasticos
Compartmental models have been widely used in order to model epidemics. Several methods have been proposed in the literature to estimate the models, specially, the least squares method, maximum likelihood estimation and Bayes estimators based on Monte Carlo simulation. In the most of real cases, the data are only partially observable. The work considers the
Publicado em: 2009
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6. A study of the spread of dengue using partial differential equations and fuzzy logic / Um estudo sobre o espalhamento da dengues usando equações diferenciais parciais e logica fuzzy
The aim of this work is to study dengue and, with this purpose, some mathematical models were created to simulate its evolution in the southern district of the city of Campinas. The human population was subdivided into three compartments, according to the state of the individuals { susceptible, infectious or recovered. The interaction between these different
Publicado em: 2009
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7. Whooping cough - theoretical evaluation of new vaccination strategies in São Paulo - Brazil / Avaliação de novas estratégias vacinais contra a coqueluche no município de São Paulo
Background: Whooping cough is a respiratory tract infection caused by Bordetella pertussis and characterized by paroxysmal cough that usually causes complications for infants, including death, and for people with chronic respiratory diseases. Immunity against pertussis after infection or vaccination is not everlasting. Despite of high childhood immunization
Publicado em: 2008
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8. Lipolysis of emulsion models of triglyceride-rich lipoproteins is altered in male patients with abdominal aorta aneurysm
Disorders of the lipid metabolism may play a role in the genesis of abdominal aorta aneurysm. The present study examined the intravascular catabolism of chylomicrons, the lipoproteins that carry the dietary lipids absorbed by the intestine in the circulation in patients with abdominal aorta aneurysm. Thirteen male patients (72 ± 5 years) with abdominal aort
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-03
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9. "Computational simulations biologically plausible of neurons of the primary somatosensory cortex" / "Simulações computacionais biologicamente plausíveis de neurônios do córtex somestésico primário"
Since its appearance, the computer has been used to model phenomena in all areas of knowledge. In neuroscience, computer modeling is used to describe, reproduce and predict behaviors of different components of the nervous system. As well as in other areas of sciences, this procedure has been shown to be efficient in the study and improvement of theories on b
Publicado em: 2006
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10. Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats
The pharmacokinetics of scorpion venom and its toxins has been investigated in experimental models using adult animals, although, severe scorpion accidents are associated more frequently with children. We compared the effect of age on the pharmacokinetics of tityustoxin, one of the most active principles of Tityus serrulatus venom, in young male/female rats
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03
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11. Further analysis of open-respirometry systems: an a-compartmental mechanistic approach
A system is said to be "instantaneous" when for a given constant input an equilibrium output is obtained after a while. In the meantime, the output is changing from its initial value towards the equilibrium one. This is the transient period of the system and transients are important features of open-respirometry systems. During transients, one cannot compute
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-08
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12. An Open Model of Actin Dendritic Nucleation
The availability of quantitative experimental data on the kinetics of actin assembly has enabled the construction of many mathematical models focused on explaining specific behaviors of this complex system. However these ad hoc models are generally not reusable or accessible by the large community of actin biologists. In this work, we present a comprehensive
The Biophysical Society.