Complement Regulatory Protein
Mostrando 1-12 de 195 artigos, teses e dissertações.
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1. Complement system contributes to modulate the infectivity of susceptible TcI strains of Trypanosoma cruzi
BACKGROUND Trypanosoma cruzi is a protozoan parasite and an etiological agent of Chagas disease. There is a wide variability in the clinical outcome of its infection, ranging from asymptomatic individuals to those with chronic fatal mega syndromes. Both parasite and host factors, as well as their interplay, are thought to be involved in the process. OBJECT
Mem. Inst. Oswaldo Cruz. Publicado em: 19/02/2018
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2. Avaliação do efeito de contraceptivos hormonais sobre o sistema complemento / Evaluation of the effect of hormonal contraceptives on the complement system
The occurrence of thrombosis is often associated with the presence of one or more risk factors, which may be genetic and/or acquired, such as hormonal changes that occur during pregnancy, hormone replacement therapy and the use of combined hormonal contraceptives (CHC). The inflammation in turn, is an important body\ s response to the aggression and involves
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
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3. Expressão de proteínas reguladoras do complemento CD55/CD59/CD35/CD46 em pacientes com artrite reumatóide
A Artrite Reumatóide (AR) é uma doença autoimune associada a poliartropatia inflamatória que acomete principalmente as articulações periféricas. Cerca de 1% da população mundial é afetada, sendo duas a três vezes mais prevalente em mulheres. Apresenta uma patogênese complexa e multifatorial. A sinóvia das articulações afetadas é infiltrada po
Publicado em: 2011
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4. The utility of anti-trypomastigote lytic antibodies for determining cure of Trypanosoma cruzi infections in treated patients: an overview and perspectives
In previous work, we proposed alternative protocols for following patients with treated Chagas disease and these are reviewed herein. Evidence was provided to support the following: (i) functional anti-trypomastigote antibodies are indicative of ongoing chronic Trypanosoma cruzi infections; (ii) specific antibodies detected by conventional serology (CS) with
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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5. Deficiências concomitantes da proteína reguladora Fator H e do componente C9 do complemento. / Concomitant deficiences of complement factor H regulatory protein and C9 component.
Our proband, Brazilian from a family of Japanese descent and history of consanguinity, carries C9 (C9D) and FH deficiencies. He was referred with severe recurrent pneumonia. FH (16,8 µg/mL), C3 and FB were present in the patient at low levels. Western blot assays confirmed the complete absence of 150 kDa (FH). His mother also had FH (140,5 µg/mL), C3 and F
Publicado em: 2007
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6. Proteomic analysis of the shistosome tegument and its surface membranes
The tegument surface of the adult schistosome, bounded by a normal plasma membrane overlain by a secreted membranocalyx, holds the key to understanding how schistosomes evade host immune responses. Recent advances in mass spectrometry (MS), and the sequencing of the Schistosoma mansoni transcriptome/genome, have facilitated schistosome proteomics. We detache
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-10
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7. Trypanosoma cruzi e o Sistema Complemento: Mecanismos de ativação e o papel do gene CRIT (Complement C2 Receptor Inhibitor Trispanning) na resistência à lise em cepas de classe I e II / Trypanosoma cruzi E O SISTEMA COMPLEMENTO: MECANISMOS DE ATIVAÇÃO E O PAPEL DO GENE CRIT (COMPLEMENT C2 RECEPTOR INHIBITOR TRISPANNING) NA RESISTÊNCIA À LISE EM CEPAS DE CLASSE I E II / Trypanosoma cruzi e o Sistema Complemento: Mecanismos de ativação e o papel do gene CRIT (Complement C2 Receptor Inhibitor Trispanning) na resistência à lise em cepas de classe I e II / Trypanosoma cruzi E O SISTEMA COMPLEMENTO: MECANISMOS DE ATIVAÇÃO E O PAPEL DO GENE CRIT (COMPLEMENT C2 RECEPTOR INHIBITOR TRISPANNING) NA RESISTÊNCIA À LISE EM CEPAS DE CLASSE I E II
Trypanosoma cruzi, the agent of Chagas disease, infects 18 million people in Latin America. T. cruzi has an heteroxicenous life cycle infecting vertebrates and invertebrate hosts. Two classes of T. cruzi have been proposed based on molecular markers, the class I with a sylvatic life cycle infecting mostly marsupials, while class II parasites have a domestic
Publicado em: 2006
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8. Uso de parasitas transgÃnicos para caracterizar o papel funcional de genes envolvidos na resistÃncia a lise pelo complemento em Tripanosomatideos
Tripanosoma cruzi and Leishmania are obligated intracellular parasites in cells of hosts mammals. However the parasites can be found in three different habitats during its cycle of life: the intestine of the insect vector, the extracellular space of the vertebrate host and in cells of the fagocÃtico system. After inoculation of metaciclic tripomastigotas fo
Publicado em: 2003
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9. Inhibition of complement-mediated cytolysis by the terminal complement inhibitor of herpesvirus saimiri.
Herpesvirus saimiri (HVS) is a lymphotropic herpesvirus that induces T-cell transformation in vitro and causes lymphomas and leukemias in New World primates other than its natural host, the squirrel monkey. Nucleotide sequence analysis of the HVS genome revealed two open reading frames with significant homology to genes for human complement regulatory molecu
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10. Humoral immune response to the Trypanosoma cruzi complement regulatory protein as an indicator of parasitologic clearance in human Chagas' disease.
Immunoprecipitation of the purified 160-kDa complement regulatory protein of Trypanosoma cruzi by Chagas' disease patient sera was examined as a possible correlate of the complement-mediated lysis test and as an indicator of parasite clearance. The results presented demonstrate that assessment of the humoral response to this antigen is a useful indicator of
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11. Stable Transfection of Trypanosoma cruzi Epimastigotes with the Trypomastigote-Specific Complement Regulatory Protein cDNA Confers Complement Resistance
Trypanosoma cruzi blood stage trypomastigotes are highly resistant to complement-mediated killing in normal serum. A previously described trypomastigote surface glycoprotein was shown to have binding affinity for human complement components C3b and C4b and restrict activation of the complement cascade, thus preventing lysis of the parasites. Insect stage epi
American Society for Microbiology.
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12. Identification of the gene family encoding the 160-kilodalton Trypanosoma cruzi complement regulatory protein.
Trypanosoma cruzi trypomastigotes are exquisitely resistant to the lytic effects of vertebrate complement, and this characteristic contributes to the survival of the parasites in the host bloodstream. Trypomastigotes avoid complement-mediated lysis by the production of a surface glycoprotein that inhibits the formation of the alternative and classical C3 con