Consomic Strains
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Aspectos da resistência à infecção experimental com Trypanosoma cruzi / Aspects of resistance to experimental infection with Trypanosoma cruzi
A doença de Chagas, zoonose causada pelo protozoário Trypanosoma cruzi, apresenta uma ampla distribuição na América Latina estendendo-se do Sul dos Estados Unidos até a Argentina. Estima-se existirem 10 milhões de pessoas infectadas e outras 25 milhões expostas ao risco. Apesar de descoberta há mais de um século, o mal de Chagas ainda é uma infec�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/12/2010
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2. Mechanism of Differential Cardiovascular Response to Propofol in Dahl Salt-Sensitive, Brown Norway, and Chromosome 13-Substituted Consomic Rat Strains: Role of Large Conductance Ca2+ and Voltage-Activated Potassium Channels
Cardiovascular sensitivity to general anesthetics is highly variable among individuals in both human and animal models, but little is known about the genetic determinants of drug response to anesthetics. Recently, we reported that propofol (2,6-diisopropylphenol) causes circulatory instability in Dahl salt-sensitive SS/JRHsdMcwi (SS) rats but not in Brow
American Society for Pharmacology and Experimental Therapeutics.
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3. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains
Whether genetics may play a role in the pathophysiologic response of kidney tubules to oxalate exposure remains unexplored despite that as many as 15% of the U.S. population annually will experience a kidney stone composed of calcium oxalate. To explore this issue, we utilized a panel of chromosome substitution strains in which one chromosome at a time was t
American Physiological Society.
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4. Parent-of-origin effects on cardiac response to pressure overload in mice
Left ventricular (LV) hypertrophy (LVH) is an independent risk factor for cardiovascular mortality and is commonly caused by hypertension. In rodents, transverse aortic constriction (TAC) is a model regularly employed in mechanistic studies of the response of the LV to pressure overload. We previously reported that inbred strains of male mice manifest differ
American Physiological Society.