Contractile Responses
Mostrando 1-12 de 182 artigos, teses e dissertações.
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1. Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction
ABSTRACT Purpose: This study aimed to assess the possible healing effect of combination treatment with a hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS) plus tadalafil on partial bladder outlet obstruction (PBOO)-induced bladder dysfunction. Materials and Methods: A total of 75 male Sprague-Dawley rats aged 10-wk and 300-350g were divided into fiv
International braz j urol. Publicado em: 2022
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2. Effects of nitric oxide inhibitors in mice with bladder outlet obstruction
ABSTRACT Purpose To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and
Int. braz j urol.. Publicado em: 2017-04
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3. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain
O-GlcNAcylation is a modification that alters the function of numerous proteins. We hypothesized that augmented O-GlcNAcylation levels enhance myosin light chain kinase (MLCK) and reduce myosin light chain phosphatase (MLCP) activity, leading to increased vascular contractile responsiveness. The vascular responses were measured by isometric force displacemen
Braz J Med Biol Res. Publicado em: 15/08/2014
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4. Pharmacological effects of the sesquiterpenic alcohol (-)-α-bisabolol in vascular and non-vascular smooth muscle preparations. / Efeitos farmacolÃgicos do Ãlcool sesquiterpÃnico (-)-α-bisabolol em preparaÃÃes isoladas de mÃsculo liso vasculares e nÃo-vasculares.
In this in vitro study the effects of the monocyclic sesquiterpene alcohol (-)-α-bisabolol on the contractile behavior of rat and mouse smooth muscle preparations were investigated. Under resting tonus, (-)-α-bisabolol relaxed duodenal smooth muscle preparations, whereas it showed biphasic effects in other smooth muscles, contracting endothelium-in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
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5. Caracterização da disfunção erétil em camundongos obesos tratados com dieta hiperlipídica / Characterization of erectile dysfunction in obese mice fed a high-fat diet
The prevalence of obesity is increasing every year, and a becoming a major public health problem. Obesity is considered an important risk factor for development of insulin resistance, dyslipidemia, diabetes mellitus type 2 and arterial hypertension. These are risk factors that act synergistically in the development of erectile dysfunction. However, so far fe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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6. Schistosomiasis differentially affects vasoconstrictor responses: up-regulation of 5-HT receptor-mediated aorta contraction
Schistosomiasis, classified by the World Health Organization as a neglected tropical disease, is an intravascular parasitic disease associated to a chronic inflammatory state. Evidence implicating inflammation in vascular dysfunction continues to mount, which, broadly defined, reflects a failure in the control of intracellular Ca2+ and consequently, vascular
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-06
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7. Gadolinium increases the vascular reactivity of rat aortic rings
Gadolinium (Gd) blocks intra- and extracellular ATP hydrolysis. We determined whether Gd affects vascular reactivity to contractile responses to phenylephrine (PHE) by blocking aortic ectonucleoside triphosphate diphosphohydrolase (E-NTPDase). Wistar rats of both sexes (260-300 g, 23 females, 7 males) were used. Experiments were performed before and after in
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-05
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8. The effects of heated vegetable oils on blood pressure in rats
OBJECTIVES: The goal of this study was to determine the possible mechanism that is involved in the blood pressureraising effect of heated vegetable oils. METHODS: Adult male Sprague-Dawley rats were divided into 11 groups; the control group was fed with rat chow, and the other groups were fed with chow that was mixed with 15% weight/weight palm or soy oils,
Clinics. Publicado em: 2011
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9. Immediate response of myocardium to pressure overload includes transient regulation of genes associated with mitochondrial bioenergetics and calcium availability
Ventricular hypertrophy is one of the major myocardial responses to pressure overload (PO). Most studies on early myocardial response focus on the days or even weeks after induction of hypertrophic stimuli. Since mechanotransduction pathways are immediately activated in hearts undergoing increased work load, it is reasonable to infer that the myocardial gene
Genetics and Molecular Biology. Publicado em: 22/01/2010
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10. Estudo das alterações da resposta vasodilatadora e vasoconstritora em aortas de ratas diabéticas e os mecanismos envolvidos. / Study of the alterations of the vasodilator and the vasoconstrictor responses in aortas of the diabetic female rats and the mechanisms involved.
Thirty days after induction of diabetes, in aortas with endothelium (E+) of diabetic female rats (DB), the maximum response (Rmax) to potassium chloride (KCl) was reduced and the Rmax to noradrenaline (NE) was similar to controls (CT). The endothelium (E-) removal increased the response to KCl and NE, but this increase was of a lower magnitude in DB than in
Publicado em: 2009
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11. Avaliação do efeito relaxante do BAY 41-2272 em detrusor isolado de coelhos / Evaluation of relaxant effect of BAY 41-2272 in rabbit isolated detrusor
Overactive bladder (OAB) is a highly prevalent condition that affects millions of people worldwide with a profound effect on quality of life. The bladder overactivity is related to spontaneous contractions of the detrusor smooth muscle causing an increase in the intravesical pressure and consequently stimulation of the micturirion reflex. Evidences suggest t
Publicado em: 2009
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12. Reactive oxygen species as signaling molecules of contraction-mediated metabolic responses in skeletal muscle. / Espécies reativas de oxigênio como sinalizadores das respostas metabólicas mediadas por contração no músculo esquelético.
Contractile activity is a potent stimulus for induce changes in glucose and fatty acid metabolism in skeletal muscle. During muscle contraction, the production of reactive oxygen species (ROS) is increased. The purpose of this study was evaluate the effect of removal of ROS, induced by treatment with the antioxidant N-Acetylcysteine, on glucose uptake, activ
Publicado em: 2008