Controlled Release Of Drugs
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded
Quím. Nova. Publicado em: 2020-06
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2. Amphotericin-B and vancomycin-loaded chitosan nanofiber for antifungal and antibacterial application
In the present study, a mucoadhesive non-woven fiber mat (d= 116 nm) was fabricated by the electrospinning method using chitosan (80% Wt), polyethylene oxide (10% Wt), cysteine (4% Wt) and drugs (6% Wt), respectively. In addition, a comparative study was conducted to define effect of drugs and mucoadhesive agent on the nanofiber formation. FTIR, SEM, DSC and
Braz. J. Pharm. Sci.. Publicado em: 09/09/2019
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3. PREPARAÇÃO, CARACTERIZAÇÃO FÍSICO-QUÍMICA E LIBERAÇÃO CONTROLADA DE MICROPARTÍCULAS DE GALACTOMANANA CONTENDO ALANTOÍNA
In this work, the allantoin was encapsulated with galactomannan extruded from Delonyx regia, by the spray drying technique. The microparticles obtained were structurally characterized by infrared spectroscopy (IR), thermal analysis, scanning electron microscopy (SEM) and the controlled release profile was evaluated. The results of IR suggested the formation
Quím. Nova. Publicado em: 2018-05
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4. Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study
ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (PCL) particle system loaded with human insulin using a simple
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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5. Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying
Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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6. Desenvolvimento e caracterização de nanofibras de acetato de celulose para liberação controlada de fármacos / Development and characterization of cellulose acetate nanofibers for controlled release of drugs
Este projeto foi desenvolvido em duas fases, usando a tecnologia de eletrofiação. A primeira fase foi dedicada a obtenção de membranas eletrofiadas com acetato de celulose, as quais formaram nanofibras que foram carregadas com Sulfato de gentamicina, na segunda fase, para estudos da liberação controlada deste fármaco. Na primeira fase as membranas de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/02/2012
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7. Fabricação e caracterização de sistemas poliméricos nanoestruturados obtidos por meio do usa da técnica de eletrofiação / Production and characterization of nanostructured polymer systems obtained by the use of electrospinning technique
The electrospinning process is known to be an efficient technique for the fabrication of polymer nanofibers. The nanofibers have great potential for application in various areas of technology such as sensors, catalysis, filtration systems and especially in the medical field in tissue engineering, controlled release of drugs, poultices for burns and other app
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/03/2011
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8. Caracterização de nanopartículas contendo insulina em modelos de animais induzidos ao diabetes / Characterization of nanoparticles containing insulin in animal models induced diabetes
Diabetes Mellitus is a disease whose cases have increased due to the bad habits of life of society. Several strategies have been developed for the treatment of diabetes, especially the controlled release of drugs. The erroneous use of insulin as basal treatment of diabetes takes a problem, since the high dose of the drug can lead to severe hypoglycemia. The
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2010
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9. Mechanism of controlled release kinetics from medical devices
Utilization of biodegradable polymers for controlled drug delivery has gained immense attention in the pharmaceutical and medical device industry to administer various drugs, proteins and other bio-molecules both systematically and locally to cure several diseases. The efficacy and toxicity of this local therapeutics depends upon drug release kinetics, which
Brazilian Journal of Chemical Engineering. Publicado em: 2010-06
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10. Estudo das alterações da membrana celular de microrganismos por compostos de inclusão de clorexidina: beta-ciclodextrina em diferentes proporções molares usando Microscopia de Força Atômica e Microscopia Eletrônica de Varredura
The formation of inclusion compounds of chlorhexidine for the controlled release of antimicrobials has shown decreasing in therapeutic concentrations effective. However, a lack of studies has been published about the mechanism which was inclusion compounds increase cellular permeability through the microorganisms membrane. Thus the objective of this work was
Publicado em: 2008
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11. Materiais mesoporosos ordenados aplicados como sistemas para liberação controlada de drogas / Ordered mesoporous materials applied as drug delivery systems
In the last decade, progress in the development of nanosized hybrid therapeutics and drug delivery systems has been remarkable. Mesoporous materials such as SBA-15 and MCM-41 have been considered very promising materials for hosting and further delivery of biological agents within silica samples and for controlling their release kinetics from the matrix due
Publicado em: 2006
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12. Desenvolvimento e avaliação farmacologica de formulações de liberação controlada com anestesicos locais amino-amidas ciclicos : bupivacaina, mepivacaina e ropivacaina / Development and pharmacological evaluation of drug-delivery systems for cyclic amino-amide local anesthetics: bupivacaine, mepivacaine and ropivacaine
Local anesthetics (LA) are among the different classes of pharmacological compounds used to attenuate or to eliminate pain. These drugs, which are able to reversibly block the excitation/transmission of the nerve impulse in axons have a relatively short action and a significant toxicity to the Central Nervous and Cardiovascular systems. In order to prolong t
Publicado em: 2005