Cost Targets
Mostrando 1-12 de 64 artigos, teses e dissertações.
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1. OTIMIZAÇÃO E VALIDAÇÃO DE MÉTODO ENZIMÁTICO SEMIQUANTITATIVO SIMPLES E DE BAIXO CUSTO PARA A BUSCA DE INIBIDORES DE CISTEINO PROTEASES
Cysteine proteases are an important class of enzymes involved in several essential biological processes. For this reason, these enzymes are important therapeutic targets, and therefore can be used in enzymatic assays for the search of hits. The most widely used methods in the search of enzyme inhibitors are spectrophotometric, however they have relatively hi
Quím. Nova. Publicado em: 2021-04
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2. Precision Medicine: Changing the way we think about healthcare
Health care has changed since the decline in mortality caused by infectious diseases as well as chronic and non-contagious diseases, with a direct impact on the cost of public health and individual health care. We must now transition from traditional reactive medicine based on symptoms, diagnosis and treatment to a system that targets the disease before it o
Clinics. Publicado em: 03/12/2018
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3. Molecular Modeling, Structural Analysis and Evaluation of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase (DXR) as a Putative Drug Target For Theileria Parva
ABSTRACT The apicomplexan parasite Theileria parva, the causative agent of ECF, is an important pathogen affecting both domestic and wild animals, causing major economic losses in the world. Problems such as high cost of drugs, development of resistance, and absence of effective vaccines prevent effective combating of the pathogen. Thus, it is necessary to e
Braz. arch. biol. technol.. Publicado em: 14/06/2018
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4. Genetic engineering of Theileria parva lactate dehydrogenase gene: a new anti-theilerial target
ABSTRACT: Theileria parva is the causative agent of East Coast Fever (ECF), a tick borne disease, which results in major economic losses in cattle. Major problems in dealing with this illness are the high cost of drugs, development of resistance, and absence of effective vaccines. Thus, exploiting new targets for cost effective and higher therapeutic value d
Pesq. Vet. Bras.. Publicado em: 2018-05
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5. Improved reverse transcription-polymerase chain reaction assay for the detection of flaviviruses with semi-nested primers for discrimination between dengue virus serotypes and Zika virus
BACKGROUND The genus Flavivirus includes a variety of medically important viruses, including dengue virus (DENV) and Zika virus (ZIKV), which are most prevalent in Brazil. Because the clinical profile of patients affected by different DENV serotypes or ZIKV may be similar, the development of new methods that facilitate a rapid and accurate diagnosis is cru
Mem. Inst. Oswaldo Cruz. Publicado em: 26/02/2018
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6. Detection of Counterfeit Durateston® Using Fourier Transform Infrared Spectroscopy and Partial Least Squares - Discriminant Analysis
Medicines containing anabolic steroids are one of the main targets for counterfeiting worldwide, including Brazil. The aim of this work was to propose a method for discriminating original and counterfeit Durateston® ampoules by Fourier transform infrared spectroscopy (FTIR) followed by chemometric analysis. Ninety-six ampoules of Durateston®, 49 originals
J. Braz. Chem. Soc.. Publicado em: 2017-07
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7. Aptamers as a promising approach for the control of parasitic diseases
ABSTRACT Aptamers are short single-stranded RNA or DNA oligonucleotides that are capable of binding various biological targets with high affinity and specificity. Their identification initially relies on a molecular process named SELEX (Systematic Evolution of Ligands by EXponential enrichment) that has been later modified in order to improve aptamer sensiti
Braz J Infect Dis. Publicado em: 2016-12
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8. Geophysical modeling in gold deposit through DC Resistivity and Induced Polarization methods
Abstract Ore mining fundamentally depends on the definition of its tenor and volume, something extremely complex in disseminated mineralization, as in the case of certain types of deposits of gold and sulfites. This article proposes the use of electrical tomography for definition of a geophysical signature in terms of electrical resistivity and chargeability
REM, Int. Eng. J.. Publicado em: 2016-09
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9. Agriculture and food security challenge of climate change: a dynamic analysis for policy selection
ABSTRACT This study presents an empirical examination of climate change related to vulnerability impacts on food security and remedial adaptation options as a suitable strategy by prioritizing needs over a 50-year period. An Empirical Dynamic Commutable General Equilibrium Model for Climate and the Economy (EDCGECE) is applied using future strategies for Mal
Sci. agric. (Piracicaba, Braz.). Publicado em: 2016-08
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10. Measurement of serum estrogen and estrogen metabolites in pre- and postmenopausal women with osteoarthritis using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
Although 17β-estradiol (E2) deficiency has been linked to the development of osteoarthritis (OA) in middle-aged women, there are few studies relating other estrogens and estrogen metabolites (EMs) to this condition. We developed a high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method to measure the l
Braz J Med Biol Res. Publicado em: 14/11/2014
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11. Validation of computationally predicted substrates for laccase
Present study reports the validation (oxidation) of computationally predicted oxidation of xenobiotic contaminants by commercially available pure laccase from Trametes versicolor. Selected contaminants were predicted as potential targets for laccase oxidation by using in-silico docking tool. The oxidation by laccase was measured by change in absorbance at sp
Braz. arch. biol. technol.. Publicado em: 2014-10
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12. Efeito de uma fosfolipase A2 básica isolada da peçonha de Bothropoides pauloensis (Bothrops pauloensis) sobre formas promastigota de Leishmania (Leishmania) amazonensis
CHAPTER 2: Leishmaniasis is a group of diseases caused by protozoa of Leishmania genus. The currently available treatment for this disease presents high toxicity and cost, parasite resistance, and difficulties of healing. In this sense, the development of new strategies for treatment of leishmaniasis is indispensable and snake venoms appear as an important n
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011