Crocidolite Asbestos
Mostrando 1-12 de 64 artigos, teses e dissertações.
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1. Resposta comparativa pleural "in vivo" e do mesotélio "in vitro" à exposição por diferentes fibras de asbesto / Comparison of in vivo pleural response and in vitro mesothelial response to different asbestos fibers
Asbestos-derived products are used thoroughly by industry. Several diseases related to asbestos exposition have been described, among them the primary tumor of the pleura mesothelioma. The mechanisms by which asbestos fibers produce injury to the pleural space are not clear. Among the factors possibly implicated are the effects secondary to an inflammatory r
Publicado em: 2006
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2. Production of interleukin 1 by rat pleural leucocytes in culture after intratracheal instillation of crocidolite asbestos.
This study was undertaken to investigate the production of interleukin 1 (IL-1) by pleural leucocytes in culture and to evaluate the influence of intratracheal instillation of crocidolite asbestos on this production. Normal pleural leucocytes spontaneously released IL-1 in culture and stimulation with lipopolysaccharide (LPS) dramatically increased productio
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3. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5.
The mechanism by which pleural mesothelial cells, the likely progenitor cells of asbestos-induced mesothelioma, recognize and internalize crocidolite asbestos is unknown. Because incubation of asbestos fibers with serum increases their association with cells, we asked whether a protein coat on asbestos increased internalization of fibers via specific cellula
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4. Enhanced lipid peroxidation and lysosomal enzyme activity in the lungs of rats with prolonged pulmonary deposition of crocidolite asbestos.
The interaction of UICC crocidolite asbestos with biological membranes in vivo was studied in rats after a single intratracheal dose of a suspension of 20 mg of fibres per rat. Development of lung fibrosis (increased level of hydroxyproline, a collagen index together with corresponding pathomorphological alteration) confirmed the penetration of crocidolite f
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5. Hydrolysis of inositol phospholipids precedes cellular proliferation in asbestos-stimulated tracheobronchial epithelial cells.
Metabolism of inositol phospholipids and phosphatidylcholine was investigated in tracheobronchial epithelial cells exposed to mitogenic concentrations of crocidolite asbestos. Alterations in levels of diacylglycerol, the endogenous activator of protein kinase C, and inositol polyphosphates, presumed mobilizers of intracellular calcium, were examined. Culture
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6. Effect of asbestos on lipid peroxidation in the red cells.
In vitro exposure of red cells to vie International Union against Cancer (UICC) standard reference asbestos samples resulted in an increase of thiobarbituric acid substances. Chrysotiles developed the largest amounts of lipid peroxides, followed by anthophyllite, amosite, and crocidolite in decreasing order. Compared with the control samples erythrocytes fre
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7. Exposure to crocidolite and the incidence of different histological types of lung cancer.
OBJECTIVES: To estimate the relations between exposure to both tobacco smoke and crocidolite and the incidence of various histological types of lung cancer. METHODS: In 1979 all former workers from the Wittenoom asbestos industry who could be traced were sent a questionnaire on smoking history. Of 2928 questionnaires sent, satisfactory replies were received
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8. Asbestosis in Experimental Animals
Previous animal experiments with asbestos dusts have been almost entirely confined to chrysotile asbestos. It was, therefore, decided to investigate the effects of mill dusts from the three types of asbestos that are produced commercially in South Africa, namely chrysotile, amosite, and crocidolite. Chrysotile and amosite samples were relatively pure while i
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9. Fibrogenic effect of wollastonite compared with asbestos dust and dusts containing quartz.
The distribution of length and diameter and the aspect ratio of crocidolite asbestos, a mineral substitute for asbestos (wollastonite), a manmade mineral fibre (glass wool), and synthetic fibres (polypropylene and polyacrylonitrite) were determined by light microscopy with phase contrast and, for crocidolite, also with transmission electron microscopy. The s
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10. Size and shape of airborne asbestos fibres in mines and mills.
There is increasing evidence that fibre size and shape play an important part in the production of health effects related to asbestos. The dimensions of airborne fibres collected at various stages of fibre processing in three mines and six mills producing three types of asbestos were measured using phase contrast light microscopy and transmission electron mi
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11. Comparison of fibre types and size distributions in lung tissues of paraoccupational and occupational cases of malignant mesothelioma.
The results of analysis of mineral fibres in lung tissues from 10 paraoccupational cases of malignant mesothelioma were compared with analysis obtained from seven cases of malignant mesotheliomas that had developed in gas mask workers. Nine of the paraoccupational cases were considered to have developed their tumours because of exposure to asbestos on their
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12. Cell population and histochemistry of asbestos related lesions of rat pleural cavity after injection of various inorganic dusts.
Rats injected intrapleurally with either crocidolite or chrysotile asbestos or silica or saline, were killed at intervals up to 2 years of age. The pleural cavities were washed out immediately after death and the washing used for enumerating cells. In addition tissue from granulomas and mesotheliomas was sectioned and stained for lysosomal enzymes. The total