Cyclic Imides
Mostrando 1-7 de 7 artigos, teses e dissertações.
-
1. QSAR-3D/CoMFA em compostos imídicos com atividade antinociceptiva
Imide compounds have shown biological activity. These compounds can be easily synthesized with good yields. The objective of this paper was the rational planning of imides and sulfonamides with antinociceptive activity using the 3D-QSAR/CoMFA approach. The studies were performed using two data sets. The first set consisted of 39 cyclic imides while the secon
Quím. Nova. Publicado em: 2013
-
2. Lewis acid free high speed synthesis of nimesulide-based novel N-substituted cyclic imides
A primeira síntese de novas imidas cíclicas derivadas de nimessulida foi realizada via reação de uma imina preparada a partir de nimessulida com anidridos apropriados na presença de acetato de sódio. Usando este processo, uma variedade de imidas cíclicas N-substituídas foi preparada em bons rendimentos em ácido acético glacial. Alguns dos compostos
Journal of the Brazilian Chemical Society. Publicado em: 2010
-
3. Antimicrobial activity and toxicity of prototype nantipirino-3,4-dicloromaleimide and its derivatives / Atividade antimicrobiana e toxicidade do protótipo n-antipirino-3,4-dicloromaleimida e seus derivados
As imidas cíclicas destacam-se como promissoras moléculas, pois apresentam interessantes propriedades biológicas, tais como analgésica, antiespasmódica, antitumoral, antiinflamatória e principalmente antimicrobiana. As imidas cíclicas podem ser de origem natural, ou obtidas através da síntese orgânica. No presente trabalho, dezoito moléculas de im
Publicado em: 2008
-
4. Aspectos químicos e potencial terapêutico de imidas cíclicas: uma revisão da literatura
Cyclic imides consists of an important family of organic compounds with therapeutic potential. In this review, emphasis will be given to the chemical and biological aspects of several sub-classes of this family, incluing maleimides, succinimides, glutarimides, naphtalimides, etc. Additionally, will be focused the contribution of our research group in this fi
Química Nova. Publicado em: 2003-03
-
5. Estudo das reações da monotosil-hidrazona de furila e compostos analogos na presença de alumina basica
The reactions of benzi1 monotosylhydrazone in basic medium and of 2-diazo-1,2-diphenyl-1-ethanone in neutral mediun with the nucleophiles hydrazineand benzoylhydrazine yielded the products (Ph2)CHCO-NH-NH-COR (48, R = -CH(Ph)2 e 49, R = -Ph) which result from the reaction of the nucleophile with the intermediate diphenylketene formed by the Wolff rearrangeme
Publicado em: 1989
-
6. Cyclic-Imide-Hydrolyzing Activity of d-Hydantoinase from Blastobacter sp. Strain A17p-4
The cyclic-imide-hydrolyzing activity of a prokaryotic cyclic-ureide-hydrolyzing enzyme, d-hydantoinase, was investigated. The enzyme hydrolyzed cyclic imides with bulky substituents such as 2-methylsuccinimide, 2-phenylsuccinimide, phthalimide, and 3,4-pyridine dicarboximide to the corresponding half-amides. However, simple cyclic imides without substituent
American Society for Microbiology.
-
7. A Novel Amidase (Half-Amidase) for Half-Amide Hydrolysis Involved in the Bacterial Metabolism of Cyclic Imides
A novel amidase involved in bacterial cyclic imide metabolism was purified from Blastobacter sp. strain A17p-4. The enzyme physiologically functions in the second step of cyclic imide degradation, i.e., the hydrolysis of monoamidated dicarboxylates (half-amides) to dicarboxylates and ammonia. Enzyme production was enhanced by cyclic imides such as succinimid
American Society for Microbiology.