Cyclic Node
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Distribution of power dividers in passive optical networks using genetic algorithms / Distribuição de divisores de potência em redes ópticas passivas utilizando algoritmos genéticos
This study, based on a genetic algorithm, optimizes the distribution of power dividers used, in the access, by passive optical networks, where each splitter has one input and several outputs. The practical scenario of distribution includes a particular city where the streets are the possible ways and the houses or buildings are the possible terminals. Starti
Publicado em: 2010
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2. Análise teórico-experimental da conexão estampada de treliça espacial de aço sob carregamentos estático e cíclico
Three-dimensional structures made of steel bars, widely known as space trusses, are very frequently used at the construction of roofs. These structures consist of steel bars, generally, connected by bolts at nodes. There are several types of connection for these 3D trusses, many are patented but others are not. In Brazil, the connection usually employed in t
Publicado em: 2008
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3. Neutrophil function and metabolism in individuals with diabetes mellitus
Neutrophils act as first-line-of-defense cells and the reduction of their functional activity contributes to the high susceptibilityto and severity of infections in diabetes mellitus. Clinical investigations in diabetic patients and experimental studies in diabetic rats and mice clearly demonstrated consistent defects of neutrophil chemotactic, phagocytic an
Brazilian Journal of Medical and Biological Research. Publicado em: 05/07/2007
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4. Differences in Cyclic AMP Changes after Stimulation by Prostaglandins and Isoproterenol in Lymphocyte Subpopulations
Various lymphocyte populations have been studied for their content in cyclic adenosine 3′,5′-monophosphate (cAMP) before and after stimulation by isoproterenol and prostaglandin E1 (PGE1). Basal cAMP levels vary among lymphocytes according to their origin: peripheral blood lymphocytes show high cAMP level while spleen and lymph node cells and thymocytes
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5. Juxtanodin: An oligodendroglial protein that promotes cellular arborization and 2′,3′-cyclic nucleotide-3′-phosphodiesterase trafficking
In the process of screening cell-type-specific genes, we identified juxtanodin (JN), an oligodendroglial protein featuring a putative C-terminal actin-binding domain. At the cellular level, JN in the rat CNS colocalized with 2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase), a cytoskeleton-related oligodendroglial protein. In the myelin sheath, JN
National Academy of Sciences.
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6. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart
Hyperpolarization-activated, cyclic nucleotide-gated cation currents, termed If or Ih, are generated by four members of the hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel family. These currents have been proposed to contribute to several functions including pacemaker activity in heart and brain, control of resting potential, and ne
National Academy of Sciences.
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7. Effects of sympathetic nerve stimulation on the sino-atrial node of the guinea-pig.
1. The effects of sympathetic nerve stimulation on the generation of pacemaker action potentials, recorded from the sino-atrial node of the guinea-pig, were determined by using intracellular recording techniques. 2. Trains of stimuli applied to the right stellate ganglion led to an increase in heart rate after a delay of a few seconds. During the initial pha
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8. Muscarinic control of the hyperpolarization-activated current (if) in rabbit sino-atrial node myocytes.
1. The mechanism by which acetylcholine (ACh), by stimulation of muscarinic receptors, acts to inhibit activation of the hyperpolarization-activated 'pacemaker' current, if was investigated in isolated rabbit sino-atrial (SA) node myocytes. 2. Intracellular loading with GTP gamma S, a non-hydrolysable analogue of GTP, did not impair the ACh action on if, but
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9. Pacemaker channel dysfunction in a patient with sinus node disease
The cardiac pacemaker current If is a major determinant of diastolic depolarization in sinus nodal cells and has a key role in heartbeat generation. Therefore, we hypothesized that some forms of “idiopathic” sinus node dysfunction (SND) are related to inherited dysfunctions of cardiac pacemaker ion channels. In a candidate gene approach, a heterozygous 1
American Society for Clinical Investigation.
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10. Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels ▿ †
Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable. Natriuretic peptides (NPs) repress fibrogenic activation of vascular smooth muscle cells (VSMCs), but the intracellular mechanism mediating this effect remains undetermined. Here we show that inhibition of RhoA through phosphorylation at Ser188, the
American Society for Microbiology (ASM).
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11. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions
Cell morphology and motility are governed largely by complex signaling networks that ultimately engage the actin cytoskeleton. Understanding how individual circuits contribute to the process of forming cellular structures would be aided greatly by the availability of specific chemical inhibitors. We have used a novel chemical screen in Xenopus cell-free extr
The National Academy of Sciences.
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12. Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes.
1. The action of the two diastereometric phosphorothioate derivatives of cAMP, Rp-cAMPs and Sp-cAMPs, was investigated on hyperpolarization-activated 'pacemaker' current (i(f)) recorded in inside-out macropatches from rabbit sino-atrial (SA) node myocytes. 2. When superfused on the intracellular side of f-channels at the concentration of 10 microM, both cAMP