Cytochromes
Mostrando 1-12 de 560 artigos, teses e dissertações.
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1. Iron restriction increases myoglobin gene and protein expression in Soleus muscle of rats
ABSTRACT Iron is an important trace element for proper cell functioning. It is present in cytochromes, hemoglobin and myoglobin (Mb), where it binds to oxygen. It is also an electron acceptor in the respiratory chain. Mb is an 18 kDa heme-protein, highly expressed in skeletal muscle and heart. The expression of several genes involved in the metabolism of iro
An. Acad. Bras. Ciênc.. Publicado em: 2016-12
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2. Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development
Early nutrition plays a long-term role in the predisposition to chronic diseases and influences the metabolism of several drugs. This may happen through cytochromes P450 (CYPs) regulation, which are the main enzymes responsible for the metabolism of xenobiotics. Here, we analyzed the effects of maternal protein restriction (MPR) on the expression and activit
Braz J Med Biol Res. Publicado em: 03/11/2016
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3. Estudo da proteína P450 óxido-redutase e dos citocromos hepáticos 2C19 e 3A4 como possíveis moduladores do fenótipo da deficiência da 21-hidroxilase / Study of P450 oxidoreductase protein and hepatic cytochromes 2C19 and 3A4 as a potential modulatory factors in 21-hydroxylase deficiency phenotype
A deficiência da 21-hidroxilase é uma doença genética comum, causada por mutações no gene CYP21A2, que codifica a enzima 21-hidroxilase (P450c21). A deficiência da 21-hidroxilase afeta a síntese de cortisol e aldosterona e promove acúmulo de precursores, que são desviados para a síntese de andrógenos. Observa-se três principais fenótipos: a for
Publicado em: 2009
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4. Efeitos neuromusculares do atracurio e do rocuronio em ratos pre-tratados com carbamazepina e fenobarbital : estudo in vitro e in vivo / Neuromuscular effects of atracurium and rocuronium in pre treated rats with carbamazepine and phenobarbital : study in vitro e in vivo
Atracurium (ATC) and rocuronium (ROC) are neuromuscular blockers of intermediate action. In this study, the neuromuscular effects had been investigated in vitro and in vivo in treated rats, by gavage (7d), with the anticonvulsantes (AC) carbamazepine (CBZ, 40 mg/kg) and phenobarbital (FB, 20 mg/kg) and sacrificed on the eight day, under anesthesia with ureth
Publicado em: 2007
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5. Uma abordagem proteomica na identificação do citocromo P450 em Prochilodus Scrofa : uma nova ferramenta em ensaios ecotoxicologicos
Cytochromes P450 constitute a superfamily of the phase I enzymes whose primary task is the detoxification of both endogenous and xenobiotic compounds. This activity is only possible through the association of CYP with cytochrome b5 and the enzyme NADPH cytochrome P450 reductase. This association is possible because of membrane environment. Any alteration in
Publicado em: 2004
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6. Arachidonic acid triggers an oxidative burst in leukocytes
The change in cellular reducing potential, most likely reflecting an oxidative burst, was investigated in arachidonic acid- (AA) stimulated leukocytes. The cells studied included the human leukemia cell lines HL-60 (undifferentiated and differentiated into macrophage-like and polymorphonuclear-like cells), Jurkat and Raji, and thymocytes and macrophages from
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-11
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7. Implicações toxicologicas e bioquimicas de xenobioticos em Curimbata (Prochilodus scrofa, Steindachnner, 1881) um peixe tropical brasileiro
Cytochromes P450 constitute a superfamily of hemeproteins that play a vital role in the metabolism of a wide variety of compounds such as steroids, fatty acids, drugs and environmental pollutants. Xenobiotic metabolism and role of cytochrome P450 are important areas of molecular pharmacology and toxicology, and of great interest mainly in the studies on prev
Publicado em: 2002
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8. Primary structure determination of two cytochromes c2: close similarity to functionally unrelated mitochondrial cytochrome C.
The amino-acid sequences of the cytochromes c2 from the photosynthetic non-sulfur purple bacteria Rhodomicrobium vannielii and Rhodopseudomonas viridis have been determined. Only a single residue deletion (at position 11 in horse cytochrome c) is necessary to align the sequences with those of mitochondrial cytochromes c. The overall sequence similarity betw
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9. Amino acid sequences of bacterial cytochromes c' and c-556.
The cytochrome c' are electron transport proteins widely distributed in photosynthetic and aerobic bacteria. We report the amino acid sequences of the proteins from 12 different bacterial species, and we show by sequences that the cytochromes c-556 from 2 different bacteria are structurally related to the cytochromes c'. Unlike the mitochondrial cytochromes
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10. Soluble cytochromes from the marine methanotroph Methylomonas sp. strain A4.
Soluble c-type cytochromes are central to metabolism of C1 compounds in methylotrophic bacteria. In order to characterize the role of c-type cytochromes in methane-utilizing bacteria (methanotrophs), we have purified four different cytochromes, cytochromes c-554, c-553, c-552, and c-551, from the marine methanotroph Methylomonas sp. strain A4. The two major
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11. Membrane cytochromes of Escherichia coli grown aerobically and anaerobically with nitrate.
Redox titration has been coupled to spectroscopic techniques, enzyme fractionation, and the use of mutants to examine the cytochrome composition of the membranes from cells grown aerobically and anaerobically with nitrate. A combination of techniques was found to be necessary to resolve the cytochromes. At least six b-type cytochromes were present. Besides c
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12. Characterization of cytochromes from Methanosarcina strain Göl and their involvement in electron transport during growth on methanol.
Methanosarcina strain Gö1 was tested for the presence of cytochromes. Low-temperature spectroscopy, hemochrome derivative spectroscopy, and redox titration revealed the presence of two b-type (b559 and b564) and two c-type (c547 and c552) cytochromes in membranes from Methanosarcina strain Gö1. The midpoint potentials determined were Em,7 = -135 +/- 5 and