Cytotoxity
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Macrophages adhesion rate on Ti-6Al-4V substrates: polishing and DLC coating effects
Abstract Introduction Various works have shown that diamond-like carbon (DLC) coatings are able to improve the cells adhesion on prosthesis material and also cause protection against the physical wear. On the other hand there are reports about the effect of substrate polishing, in evidence of that roughness can enhance cell adhesion. In order to compare and
Res. Biomed. Eng.. Publicado em: 2016-06
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2. Micro-organismos de interesse farmacêutico e agrícola: estudo químico e biossintético / Microorganisms of pharmaceutical and agricultural interests: chemical and biosynthetic studies
The microbial biodiversity from different ecosystems has incited chemical and biological studies with microorganisms from several habitats, leading to the isolation of bioactive natural products with applications in medicine, chemical industry and agriculture, and thus contributing to a better quality of life. This thesis aimed the biopropecting on endophyti
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2012
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3. Toxicidade de aminoacetona e células produtoras de insulina / Cytotoxity of aminoacetone on insulin-producing cells
Danos induzidos por hiperglicemia em tecidos no diabetes são caracterizados por quatro mecanismos conectados: aumento do fluxo metabólico através da via do poliol, ativação da proteína quinase C (PKC), aumento da atividade da via das hexosaminas e aumento da produção intracelular dos precursores dos produtos finais de glicação avançada (AGEs). Ent
Publicado em: 2010
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4. Evaluation of cytotoxity of carbamide peroxide and protector effect of sodium ascorbate on odontoblast-like cells MDPC-23 / Avaliação da citotoxicidade do peroxidode carbamida e do efeito protetor do ascorbato de sodio sobre celulas odontoblasticas MDPC-23
Os objetivos do presente trabalho foram: a) avaliar os efeitos citotóxicos diretos e transdentinário de diferentes concentrações de peróxido de carbamida (PC) sobre as células de linhagem odontoblástica MDPC-23; b) avaliar o efeito protetor (antioxidante) do ascorbato de sódio (AS) sobre estas células expostas a agentes clareadores, na forma direta
Publicado em: 2009
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5. Micro/nanosferas de poli (L-lactico-CO-glicolico) e complexos de ß-ciclodestrinas contendo desidrocrotonina como uma possivel alternativa na terapia contra leucemias / Micro/nanospheres of poly (lactin-CO-glycolic) and beta-cyclodextrins complexes containing dehydrocrotonin as a possible leukaemia therapy
Nos últimos anos, a busca por alternativas mais eficientes e menos tóxicas para a terapia de diversas doenças despertou interesse em pesquisadores de diversas áreas, particularmente as que envolvam a utilização de polímeros biodegradáveis no desenvolvimento de sistemas de liberação controlada de hormônios, fármacos anti-câncer, antibióticos e v
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/01/2008
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6. Nitrosilo complexos de rutênio : síntese, caracterização e avaliação de suas potencialidades citotóxicas / Nitrosyl ruthenium complexes : synthesis, characterization and evaluation of its cytotoxic potentialities
The behavior of nitric oxide (NO) in biological systems has been under intense investigation in recent years in view of its possibly crucial role in a variety of physiological processes. Great progress in this area has been achieved by studying nitrosyl transition metal complexes. In this sense ruthenium complexes are by far the most studied and their relati
Publicado em: 2008
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7. Investigação de lesões em DNA induzidas pelo hidrocarboneto policíclico aromático antantreno / Investigation of DNA damage induced by polycyclic aromatic hydrocarbon anthanthrene.
Anthanthrene is a polycyclic aromatic hydrocarbon (PAH) widely spread in the environment and does not have the bay or fjord regions, which in general provide high reactivity to these compounds after oxidation. However, its mutagenic activity to bacteria after metabolic activation is comparable to that of benzopyrene (BP) and, based on the sensitivity of the
Publicado em: 2007
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8. Neutral endopeptidase 24.11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils-induced endothelial cytotoxity.
This study was performed to determine effects of atrial and brain natriuretic peptides (ANP, BNP) on neutrophils-induced endothelial injury which is known to play a role in the pathophysiology of ischemia/reperfusion myocardial injury and to examine whether the effects of ANP and BNP on neutrophils are modulated by neutral endopeptidase 24.11 (NEP) in neutro
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9. Inhibition of glycosylation of bovine herpesvirus 1 glycoproteins by the thymidine analog (E)-5-(2 Bromovinyl)-2'-deoxyuridine.
(E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVdU) was phosphorylated by the bovine herpesvirus 1 (BHV-1)-induced thymidine kinase and subsequently incorporated into viral DNA, resulting in DNA that was more dense than DNA from untreated cells. Incorporation of the drug did not result in the termination of replicating BHV-1 DNA molecules since radioactively labeled
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10. N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity
Peptide deformylase (PDF) is a prokaryotic metalloenzyme that is essential for bacterial growth and is a new target for the development of antibacterial agents. All previously reported PDF inhibitors with sufficient antibacterial activity share the structural feature of a 2-substituted alkanoyl at the P1′ site. Using a combination of iterative parallel syn
American Society for Microbiology.