Deiodinase
Mostrando 1-12 de 70 artigos, teses e dissertações.
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1. Goitrogenic/antithyroidal potential of moringa leaves (Moringa oleifera) and spinach (Spinacia oleracea) of Indian origin on thyroid status in male albino rats
Moringa leaves and spinach used as vegetables containing cyanogens and polyphenols having suspected antithyroidal activity; however, detailed studies in this aspect found unavailable. Goitrogenic/antithyroid potentiality of those plant foods of Indian origin was evaluated. To explore the goitrogenic/antithyroid effect of those plant foods cyanogenic glucosid
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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2. Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats
Considering the recognized role of thyroid hormones on the cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, the main activation pathway of thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate thyroid hormone status, which would then constitute a possible target for β-adrenergic
Braz J Med Biol Res. Publicado em: 10/10/2019
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3. Expressão da Desiodase do Tipo III no cérebro de filhotes de ratas obesas
A obesidade é uma epidemia de ordem mundial que é fator de risco para o desenvolvimento de hipertensão arterial, dislipidemia, hiperglicemia, diabetes tipo 2 e esteatose hepática. O aumento de obesidade em gestantes além de aumentar o risco do desenvolvimento de doenças cardiovasculares, também pode estar relacionado com anomalias no desenvolvimento d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/08/2012
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4. A sinalização parácrina da triiodotironina derivada das células gliais ativa a expressão de genes neuronais no cérebro de roedores e em células humanas / A paracrine signaling of triiodothyronine derived from glial cells activates the expression of neuronal genes in brain of rodents and in human cells
O hipotiroidismo nos humanos caracteriza-se por distúrbios neurológicos graves, frequentemente irreversíveis, que ressaltam o papel crítico dos hormônios tiroidianos (HT) no cérebro. Apesar disto, pouco se sabe sobre as vias de sinalização que controlam a ação dos HT no cérebro. O que é conhecido é que a tiroxina (T4), um pró-hormônio, é conv
Publicado em: 2010
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5. Os hormônios tireoideanos e o desenvolvimento esquelético fetal e pós-natal: estudo do padrão de expressão dos transportadores e das selenodesiodases das iodotironinas. / Thyroid hormone and skeletal development at fetal and postnatal ages: the expression pattern of iodothyronine transporters and deiodinases.
Thyroid hormone (TH) plays a key role on post-natal bone development and metabolism, while its relevance during fetal bone development is uncertain. To study this, pregnant mice and fetuses were made hypothyroid. The skeleton morphology was preserved up to 16.5 embryonic days (E). Only at E18.5, the hypothyroid fetuses exhibited a reduction in femoral type I
Publicado em: 2009
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6. Expressão das lodotironinas desiodases tipo 1 e tipo 2 nas neoplasias de tireóide
Resumo não disponível.
Publicado em: 2007
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7. Expressão das iodotironinas desiodases tipos I e II em diferentes tecidos de camundongos normais e com deficiência inata para a desiodase tipo I
Duas enzimas, as iodotironinas desiodases tipos I e II (D1 e D2), catalizam a reação de 5’ desiodação do T4 promovendo a formação do hormônio tireoidiano ativo, T3. A D1, principal fonte de T3 circulante no plasma, esta presente no fígado, rim e tireóide. Até recentemente, acreditava-se que a expressão da D2 estivesse restrita a tecidos nos quai
Publicado em: 2007
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8. Aspectos metabólicos e funcionais do zinco na síndrome de Down
Este estudo relata os aspectos funcionais do zinco, bem como a participação desse mineral nas alterações metabólicas presentes em indivíduos portadores de Síndrome de Down. A maioria dos trabalhos realizados observou que o estado nutricional relativo ao zinco nesses pacientes está inadequado, com alterações no sistema antioxidante, imunológico e n
Revista de Nutrição. Publicado em: 2006-08
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9. Somatostatin inhibits rat hepatic T4-5'-deiodinase. The effect is independent of the associated hypoinsulinemia.
Somatostatin decreases the serum 3,5,3'-triiodothyronine (T3) concentration in athyreotic subjects treated with L-thyroxine (T4). The present study was performed to determine the effect of somatostatin on T4-5'-deiodinase activity in rat tissue homogenate preparations. This enzyme is an important regulator of T3 production. Continuous somatostatin infusion a
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10. A thyroid hormone-regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase.
The type III iodothyronine 5-deiodinase metabolizes thyroxine and 3,5,3'-triiodothyronine to inactive metabolites by catalyzing the removal of iodine from the inner ring. The enzyme is expressed in a tissue-specific pattern during particular stages of development in amphibia, birds, and mammals. Recently, a PCR-based subtractive hybridization technique has b
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11. Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex.
Enzymatic 5'-deiodination of 3,3',5'-triiodothyronine (rT3) and 3,3',5,5'-tetraiodothyronine (thyroxine, T4) was studied in microsomal preparations of rat cerebral cortex. Evidence was obtained for the existence of two thiol-dependent 5'-deiodinase entities. One of these predominates in tissue from euthyroid and long-term hypothyroid rats, is specific for rT
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12. Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase
One of the genes that is up-regulated by thyroid hormone (TH) during Xenopus laevis metamorphosis encodes a type III deiodinase (D3) that inactivates TH. Transgenic X. laevis tadpoles overexpressing a GFP-D3 fusion protein were produced. These transgenic tadpoles had high levels of deiodinase activity and were resistant to exogenous TH added 1 week after fer
The National Academy of Sciences.