Delta Aminolevulinate Dehydratase D Ala D
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. EFFECT OF THE ACUTE EXERCISE OF SHORT DURATION IN THE ENZYME δ-AMINOLEVULINATO DEHYDRATASE ACTIVITY IN HUMAN / EFEITO DO EXERCÍCIO AGUDO DE CURTA DURAÇÃO NA ATIVIDADE DA ENZIMA δ-AMINOLEVULINATO DESIDRATASE EM HUMANOS
Aerobic exercise of sufficient intensity and duration can result in increased generation of reactive oxygen species and exercise of extreme endurance may cause oxidative stress with a concomitant decreased activity of antioxidant defense systems. The aim of this study was to investigate the possible effect of a peak of oxidative stress exposition on the acti
Publicado em: 2009
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2. Atividade da Delta Aminolevulinato desidratase sangüínea e o estresse oxidativo em pacientes hemodialisados / Human erythrocyte delta-aminolevulinate dehydratase activity and oxidative stress in hemodialysis patients
A ácido delta aminolevulinato desidratase (δ-ALA-D) é uma enzima tiólica, envolvida na biossíntese de compostos tetrapirrólicos, como o heme. Essa enzima é inibida por vários metais, sendo inclusive sua inibição um indicador de intoxicação por chumbo (Pb). Adicionalmente, muitos estudos sugerem sua inibição como um marcador do estresse oxid
Publicado em: 2007
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3. Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism / Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALAD) no diabetes mellitus e no hipotireoidismo
The activity of Delta-Aminolevulinate Dehydratase (d-ALA-D) was analyzed in patients suffering from diabetes mellitus and primary hypothyroidism. Five groups of patients were studied: compensated diabetes mellitus, non-compensated diabetes mellitus, compensated hypothyroidism, non-compensated hypothyroidism and control group. The analysis of d-ALA-D in these
Publicado em: 2004
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4. A INIBIÇÃO DA ENZIMA δ-AMINOLEVULINATO DESIDRATASE POR MONOSSACARÍDEOS NÃO É MEDIADA PELA OXIDAÇÃO DE GRUPOS -SH
Heme pathway enzyme δ-aminolevulinate dehydratase (δ-ALA-D) is a good marker for oxidative stress and metal intoxication. This sulfhydrylic enzyme is inhibited in several oxidative pathologies like lead, mercury and aluminum intoxication, selenium organic species exposition and diabetes. Oxidative stress is one of cause of diabetes complications. T
Publicado em: 2004
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5. Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves
The interaction of the product of H2O2 and (PhSe)2 with delta-aminolevulinate dehydratase (delta-ALA-D) from mammals and plants was investigated. (PhSe)2 inhibited rat hepatic delta-ALA-D with an IC50 of 10 µM but not the enzyme from cucumber leaves. The reaction of (PhSe)2 with H2O2 for 1 h increased the inhibitory potency of the original compound and the
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-06
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6. Effects of lead and/or zinc exposure during the second stage of rapid postnatal brain growth on delta-aminolevulinate dehydratase and negative geotaxis of suckling rats
Lead has been shown to produce cognitive and motor deficits in young rats that could be mediated, at least in part, by inhibition of the zinc-containing heme biosynthetic enzyme delta-aminolevulinate dehydratase (ALA-D). In the present study we investigated the effects of lead and/or zinc treatment during the second stage of rapid postnatal brain development
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-06
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7. Human delta-aminolevulinate dehydratase: nucleotide sequence of a full-length cDNA clone.
Two cDNAs encoding human delta-aminolevulinate dehydratase (ALA-D; porphobilinogen synthase; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, were identified, recloned into bacteriophage M13, and sequenced by primer extension. The first clone with an 827-base-pair (bp) pEX-ALA-D cDNA insert, shown to contain DNA sequences that were colinear