Diacerein
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Análise do impacto orçamentário da viscossuplementação no tratamento não cirúrgico da osteoartrite de joelho
Resumo: A osteoartrite de joelho afeta cerca de 3,8% da população mundial e se manifesta por dor, edema, rigidez e redução da função articular, impactando na qualidade de vida do paciente. O tratamento consiste na modalidade farmacológica, não farmacológica e cirúrgica. A viscossuplementação (ácido hialurônico intra-articular) se propõe a ofer
Cad. Saúde Pública. Publicado em: 07/10/2019
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2. Diacerein, its beneficial impact on chondrocytes and notable new clinical applications
Diacerein (DCN) was obtained by diacetylation of an anthraquinone derivative rhein and was approved by FDA in 2008, in the treatment of osteoarthritis due to its inhibitory effect on proinflammatory cytokines, including IL-6 and IL-1β. It was synthesized in 1980s and marketed as a tablet in some European Union and Asian countries from 1994. Along with its g
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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3. A comparative study of two separate analytical techniques for the simultaneous determination of diclofenac sodium and diacerein from combined dosage form
ABSTRACT Diclofenac sodium (DS) and diacerein (DC) have emerged as a potential combination therapy for the treatment of knee osteoarthritis. Therefore a validated analytical method is essential for the simultaneous estimation of both from combined dosage form. A ratio derivative spectrophotometric and a chromatographic technique have been developed for the s
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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4. Effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus and inadequate glycemic control
ABSTRACT Objective To evaluate the effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control. Materials and methods A randomized, double-blind, placebo-controlled clinical trial was carried out on 12 patients with T2DM and inadequate glycemic control [glycated hemoglobin A1c (A1C) ≥ 7
Arch. Endocrinol. Metab.. Publicado em: 13/02/2017
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5. EFEITO DA DIACEREÍNA SOBRE A FEBRE INDUZIDA POR SUSPENSÃO DE Saccharomyces cerevisiae E POR PROSTAGLANDINA E2 EM RATOS JOVENS. / EFFECT OF DIACEREIN ON BAKER YEAST- AND PROSTAGLANDIN E2-INDUCED FEVER IN YOUNG RATS.
Fever is a systemic response that results of a cascade of events that usually begins with pathogenic infection. Its development represents an important aspect of host defense that is mediated by the central nervous system. However, antipyretic medication are routinely prescribed because fever is associated with discomfort and anxiety, apart from to represent
Publicado em: 2005
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6. Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols
The impact of diacerein, an effective cartilage targeted therapy that is used in patients with osteoarthritis, on the development and progression of chronic inflammatory arthritis was evaluated in a tumor necrosis factor (TNF) transgenic mouse model (Tg197). The response to diacerein at 2, 20, or 60 mg/kg daily, as well as the comparative effects of other an
BioMed Central.