Dna Spontaneous Damage
Mostrando 1-12 de 174 artigos, teses e dissertações.
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1. In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1
ABSTRACT Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and vir
Braz J Infect Dis. Publicado em: 2018-03
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2. Estudo de Danos Oxidativos Espontâneos no DNA de Pacientes com Lesões Malignas e Benignas de Mama. / Spontaneous Oxidative Damage in DNA of Patients with Malignant and Benign Breast Lesions.
O estresse oxidativo é um dos principais responsáveis pela produção de danos espontâneos no DNA, os quais podem levar à origem de diversas neoplasias, inclusive câncer de mama (CM). Além disso, dentre os diversos fatores de risco já estabelecidos para a ocorrência do CM em mulheres, como idade, hormônios, dieta e fatores genéticos, alguns tipos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/11/2011
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3. Influência de polimorfismos em genes de metabolismo de xenobióticos e reparação de DNA no risco ocupacional de mineiros de carvão a céu aberto
Colombia has one of the world s largest coal reserves being the fifth biggest thermal coal exporter world-wide. In open-cast coal mining extraction, large amounts of dust particles and heavy metals are released into the atmosphere, where they can form complex mixtures, representing a significant health risks to occupationally exposed workers. In addition, in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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4. Avaliação do potencial de mutagenicidade e toxidade da lectina hipoglicemiante de folha de Bauhinia monandra (pata-de-vaca)
Medicinal plants have been used since antiquity to treat various human diseases. The leaves of Bauhinia monandra are widely used in Brazil as herbal remedies in the treatment of Diabetes Mellitus. From the leaves of B. monandra was purified a galactose-specific lectin, called BmoLL, which also showed a significant hypoglycemic capacity. Following the propose
Publicado em: 2009
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5. Activation of the DNA Damage Checkpoint in Yeast Lacking the Histone Chaperone Anti-Silencing Function 1
The packaging of the eukaryotic genome into chromatin is likely to be important for the maintenance of genomic integrity. Chromatin structures are assembled onto newly synthesized DNA by the action of chromatin assembly factors, including anti-silencing function 1 (ASF1). To investigate the role of chromatin structure in the maintenance of genomic integrity,
American Society for Microbiology.
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6. c-Jun-Deficient Cells Undergo Premature Senescence as a Result of Spontaneous DNA Damage Accumulation
Mouse embryo fibroblasts deficient for the c-Jun proto-oncogene (c-Jun−/− MEF) undergo p53-dependent premature senescence in conventional culture. This phenotype becomes evident only after several cell divisions, suggesting that senescence may result from exposure to unknown environmental factors. Here, we show that c-Jun−/− MEF can proliferate succe
American Society for Microbiology.
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7. Spontaneous Mitotic Recombination and Evidence for an X-Ray-Inducible System for the Repair of DNA Damage in DROSOPHILA MELANOGASTER
Spontaneous mitotic recombination in the left arm of chromosome 3 was examined in both unirradiated control flies and sibs irradiated early in development by determining the sizes and frequencies of multiple-wing-hair (mwh) clones in the wing blade of heterozygous mwh/+ flies. Approximately 16% of the spontaneous mwh clones arise from events generating cells
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8. Functional genomics reveals a family of eukaryotic oxidation protection genes
Reactive oxygen species (ROS) are toxic compounds produced by normal metabolic processes. Their reactivity with cellular components is a major stress for aerobic cells that results in lipid, protein, and DNA damage. ROS-mediated DNA damage contributes to spontaneous mutagenesis, and cells deficient in repair and protective mechanisms have elevated level
The National Academy of Sciences.
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9. In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.
Three genes that participate in the repair of DNA alkylation damage were recently cloned from Saccharomyces cerevisiae: the MGT1 O6-methylguanine DNA methyltransferase gene, the MAG 3-methyladenine DNA glycosylase gene, and the APN1 apurinic/apyrimidinic (AP) endonuclease gene. Altering the expression levels of these three genes produced significant changes
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10. Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium.
Salmonella typhimurium strains containing deletions of oxyR, a positive regulator of defenses against oxidative stress, show 10- to 55-fold higher frequencies of spontaneous mutagenesis compared to otherwise isogenic oxyR+ control strains. The high spontaneous-mutation frequency in oxyR deletion strains is decreased by a factor of 3 when the strains are grow
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11. Multiple recombination pathways for sister chromatid exchange in Saccharomyces cerevisiae: role of RAD1 and the RAD52 epistasis group genes
Sister chromatid exchange (SCE) can occur by several recombination mechanisms, including those directly initiated by double-strand breaks (DSBs), such as gap repair and break-induced replication (BIR), and those initiated when DNA polymerases stall, such as template switching. To elucidate SCE recombination mechanisms, we determined whether spontaneous and D
Oxford University Press.
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12. Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae
Reactive oxygen species (ROS), generated by endogenous and exogenous sources, cause significant damage to macromolecules, including DNA. To determine the cellular effects of induced, oxidative DNA damage, we established a relationship between specific oxidative DNA damage levels and biological consequences produced by acute H2O2 exposures in yeast strains de
Oxford University Press.