Dnqx
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. AÇÃO FARMACOLÓGICA DO 3-ALQUINIL SELENOFENO EM MODELOS DE CONVULSÃO EM RATOS JOVENS / PHARMACOLOGICAL ACTION OF 3-ALKYNYL SELENOPHENE ON MODELS OF SEIZURES IN RAT PUPS
As convulsões têm conseqüências importantes em termos de mortalidade e qualidade de vida da população afetada, sendo um fator de risco para o desenvolvimento de alterações cognitivas e anormalidades comportamentais. Tendo em vista as promissoras propriedades farmacológicas das moléculas contendo selênio, no artigo 1 avaliamos a ação anticonvulsi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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2. Efeitos do óleo essencial de Ocimum basilicum L. e do (-)-linalol na nocicepção orofacial e na excitabilidade do sistema nervoso de roedores. / EFFECTS OF THE ESSENTIAL OIL OF Ocimum basilicum L. AND (-)-linalool, orofacial nociception NA NA nervous system excitability RODENT
O objetivo deste trabalho foi estudar a ação antinociceptiva do Óleo Essencial (OE) obtido das folhas do Ocimum basilicum e do (-)-linalol no modelo de dor (nocicepção) orofacial e na excitabilidade periférica e central. O gênero Ocimum possui várias espécies com os mais variados usos: antinociceptivo, antiespasmódico, sedativo e como repelente de
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/03/2011
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3. Efeito da microinjeção de antagonista dos receptores glutamatérgicos do tipo AMPA no centro e na concha do Núcleo Accumbens sobre a emocionalidade e ingestão de alimento, em ratos Wistar fêmeas
O presente estudo teve como objetivo avaliar o efeito da microinjeção de antagonista dos receptores AMPA (a-amino-3-hidroxi-5-metil-4-isoxazolproprionato) no Núcleo Accumbens (NAcc) sobre a emocionalidade e ingestão de alimento em ratos Wistar fêmeas. Investigou-se, no experimento 1, se a microinjeção de DNQX (6,7-Dinitroquinoxalina-2,3-diona), na con
Publicado em: 2008
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4. 1,2 AND 1,4-DICARBOXYLIC COMPOUNDS ACTUATE ON THE GLUTAMATERGIC SYSTEM AND THE BEHAVIOR OF RATS AND MICE / COMPOSTOS 1,2 E 1,4-DICARBOXÍLICOS ATUAM SOBRE O SISTEMA GLUTAMATÉRGICO E O COMPORTAMENTO DE RATOS E CAMUNDONGOS
Glutamatergic receptors are targets for many L-glutamate structure analogues, which cause neurotoxicity. This study investigated the actions of two dicarboxylic compounds, the first had cyclic framework and rigid structure, and the other had an acyclic framework and flexible structure, on the glutamatergic neurotransmission, oxidative damage and behavior in
Publicado em: 2005
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5. Involvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in mice.
We studied the effects of gamma-aminobutyric acid (GABA)-benzodiazepine receptor agonists and glutamate receptor antagonists on levofloxacin (LVFX)- and ciprofloxacin (CPFX)-induced convulsions using intrathecal (i.t.) injections in mice. We also studied the effects of these agonists and antagonists on exacerbated convulsions induced by coadministration of t
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6. Intracellular electrophysiological study of suprachiasmatic nucleus neurons in rodents: excitatory synaptic mechanisms.
1. To study the synaptic mechanisms of excitatory transmission in the suprachiasmatic nucleus (SCN), we assessed the effects of excitatory amino acid receptor antagonists on excitatory postsynaptic potentials (EPSPs) recorded from SCN neurons in horizontal and parasagittal hypothalamic slice preparations from rats and guinea-pigs. The EPSPs were evoked by el
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7. Rapid and Sensitive Mapping of Long-Range Connections In Vitro Using Flavoprotein Autofluorescence Imaging Combined With Laser Photostimulation
We investigated the use of flavoprotein autofluorescence (FA) as a tool to map long-range neural connections and combined FA with laser-uncaging of glutamate to facilitate rapid long-range mapping in vitro. Using the somatosensory thalamocortical slice, we determined that the spatial resolution of FA is ≥100–200 μm and that the sensitivity for detecting
American Physiological Society.
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8. Differential Involvement of NMDA and AMPA Receptors Within the Nucleus Accumbens in Consolidation of Information Necessary for Place Navigation and Guidance Strategy of Mice
Recent evidence now points to a role of glutamate transmission within the nucleus accumbens (Nacc) in spatial learning and memory. Unfortunately, the role of the distinct classes of glutamate receptors within this structure in mediating the different steps of the memorization process is not clear. The aim of this study therefore was to further investigat
Cold Spring Harbor Laboratory Press.
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9. Horizontal cell feedback regulates calcium currents and intracellular calcium levels in rod photoreceptors of salamander and mouse retina
We tested whether horizontal cells (HCs) provide feedback that regulates the Ca2+ current (ICa) of rods in salamander and mouse retinas. In both species, hyperpolarizing HCs by puffing a glutamate antagonist, 6,7-dinitro-quinoxaline-2,3-dione (DNQX), onto HC processes caused a negative shift in the voltage dependence of rod ICa and increased its peak amplitu
Blackwell Science Inc.
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10. Effects of new non-N-methyl-D-aspartate antagonists on synaptic transmission in the in vitro rat hippocampus.
1. The effects of new, potent non-N-methyl-D-aspartate (NMDA) receptor antagonists, 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), have been examined using intra- and extracellular recordings in the hippocampal slice preparation. In terms of potency and selectivity, the action of the two blockers was similar and CNQX
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11. Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarii in rats.
1. The goal of the present study was to identify potential neurotransmitter candidates in the Breuer-Hering (BH) reflex pathway, specifically at synapses between the primary afferents and probable second-order neurones (pump cells) within the nucleus tractus solitarii (NTS). We hypothesized that if activation of specific receptors in the NTS is required for
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12. Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat.
1. The metabotropic glutamate (mGlu) response was investigated in dissociated rat hippocampal CA1 pyramidal neurones using conventional and nystatin-perforated whole-cell modes of the patch recording configuration. 2. In the perforated patch recording configuration, the application of glutamate (Glu), quisqualate (QA), aspartate (Asp) and N-methyl-D-aspartat