Dorsal Raphe Nucleus
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe
Pathophysiological mechanisms involved in orofacial pain and their relationship with emotional disorders have emerged as an important research area for multidisciplinary studies. In particular, temporomandibular disorders (TMD) have been evaluated clinically from both physiological and psychological perspectives. We hypothesized that an altered neuronal acti
Braz J Med Biol Res. Publicado em: 2020-08
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2. Tryptophan overloading activates brain regions involved with cognition, mood and anxiety
ABSTRACT Tryptophan is the only precursor of serotonin and mediates serotonergic activity in the brain. Previous studies have shown that the administration of tryptophan or tryptophan depletion significantly alters cognition, mood and anxiety. Nevertheless, the neurobiological alterations that follow these changes have not yet been fully investigated. The ai
An. Acad. Bras. Ciênc.. Publicado em: 16/02/2017
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3. Fos expression in the prefrontal cortex and mesencephalic dorsal raphe nucleus in lactating rats after social instigation
Females are often less aggressive than males, but they exhibit high levels of agonistic behavior against an intruder in the area of the nest during lactation. This behavior is referred to as maternal aggression. In rats, maternal aggressive behavior occurs more often from postpartum day 3 (PPD 3) to PPD 12. Social instigation is an experimental protocol used
Psychol. Neurosci.. Publicado em: 2013-06
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4. 5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus
The dorsal raphe nucleus (DRN) is the origin of ascending serotonergic projections and is considered to be an important component of the brain circuit that mediates anxiety- and depression-related behaviors. A large fraction of DRN serotonin-positive neurons contain nitric oxide (NO). Disruption of NO-mediated neurotransmission in the DRN by NO synthase inhi
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04
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5. Towards a translational model of panic attack
About 20 years ago, Deakin and Graeff proposed that whereas generalized anxiety disorder is produced by the overactivity of 5-HT excitatory projections from dorsal raphe nucleus to the areas of prefrontal cortex and amygdala which process distal threat, panic attacks are a dysfunction of 5-HT inhibitory projections from dorsal raphe nucleus to the dorsal per
Psychology & Neuroscience. Publicado em: 2010-06
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6. Hormonal and cognitive factors associated with the exploratory behavior of rats submitted to repeated sessions of the elevated plus-maze
Naive rats submitted to the elevated plus-maze (EPM) display a characteristic increase in open arm exploration and reduced risk assessment behaviors (RABs) after the administration of anxiolytic drugs. Upon re-exposure to the maze, however, the traditional measures of the EPM become resistant to these drugs. This intriguing phenomenon was initially observed
Psychology & Neuroscience. Publicado em: 2010-06
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7. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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8. DistribuiÃÃo e anÃlise quantitativa de neurÃnios imunoreativos à enzima triptofano hidroxilase em nÃcleos de rafe de ratos desnutridos durante a vida perinatal / Distribution and quantitative analysis of neurons immunoreactive for the enzyme tryptophan hydroxylase in the raphe nuclei of animals malnourished during perinatal life
Nutritional disorders occurring during the development of the nervous system may program the fetal metabolism so long to allow the survival of individuals to changes in the nutritional environment. The perinatal protein malnutrition promotes neurochemical changes, including the levels of serotonin and limiting enzyme for its synthesis, tryptophan hydroxylase
Publicado em: 2009
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9. Organização das projeções do córtex pré-fontral para o núcleo dorsal da rafe no rato. / Organization of the projections from the prefrontal cortex to the dorsal raphe nucleus in the rat.
O núcleo dorsal da rafe (DR) envia densas projeções para o prosencéfalo e está implicado em várias funções complexas. Muitos estudos indicam que a atividade neuronal do DR é controlada por neurônios do córtex pré-frontal (PFC). Devido à escassez de informações detalhadas sobre as conexões entre o PFC e o DR, objetivamos mapear sistematicament
Publicado em: 2008
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10. Aspectos do envelhecimento cerebral e função cognitiva em modelo experimental animal e estudo de mecanismos de neurodegeneração em cultura celular
The two phenomena, biological and behavioural, approached in the present work are brain aging and spatial memory. Several studies, comparative and experimental, have shown that aged subjects present significantly impaired performances in different types of cognitive tasks. It is also known that contradictions in literature exist in relation to consequences o
Publicado em: 2007
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11. Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite
We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium and water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 µg/0.2 µl, in a single dose, ibotenic acid (IBO-DRN, N = 9 to 10) through a guide cannula into the DRN and were observed for 21 days in order
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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12. c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization
In laboratory animals, acupuncture needs to be performed on either anesthetized or, if unanesthetized, restrained subjects. Both procedures up-regulate c-Fos expression in several areas of the central nervous system, representing therefore a major pitfall for the assessment of c-Fos expression induced by electroacupuncture. Thus, in order to reduce the effec
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-12