Dorsal Root Ganglion
Mostrando 1-12 de 237 artigos, teses e dissertações.
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1. EVALUATION OF THE LUMBAR SAFETY TRIANGLE THROUGH MAGNETIC RESONANCE IMAGING
RESUMO Objetivo: Avaliar a zona triangular de segurança lombar, seus limites e sua relação com o gânglio da raiz dorsal por meio da ressonância magnética (RM). Métodos: Foram estudados os limites, o formato e as dimensões de 303 zonas triangulares de segurança no corte coronal de RM 3.0 Tesla de L2 a L5, incluindo o gânglio da raiz dorsal. Resul
Coluna/Columna. Publicado em: 14/11/2019
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2. Small RNA sequencing reveals microRNAs related to neuropathic pain in rats
The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles in the pathogenesis and development process of neuropathic pain. The rat model of neuropathic pain caused by spared nerve injury (SNI) was established in Sprague-Dawley male rats, followed by small RNA sequencing of the L3–L6 d
Braz J Med Biol Res. Publicado em: 16/09/2019
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3. Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury
Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by high-throughput Illumina HiSeq2500 sequencing to profile t
Braz J Med Biol Res. Publicado em: 26/07/2018
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4. NF-kB mediated CX3CL1 activation in the dorsal root ganglion contributes to the maintenance of neuropathic pain induced in adult male Sprague Dawley rats
Abstract Purpose: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. Methods: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested at relevant time points during an observation period of 28
Acta Cir. Bras.. Publicado em: 2018-07
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5. Exogenous neuregulin-1 attenuates STZ-induced diabetic peripheral neuropathic pain in rats
Abstract Purpose: To investigate whether modulating NRG1 could attenuate diabetic neuropathic pain and analyze the underlying mechanism. Methods: Male SD rats were randomly divided into control group, diabetic group, NRG1 intervention group. After STZ-induced 2 weeks, NRG1 intervention daily for consecutive 7 days. 4 weeks after NRG1 intervention, both the
Acta Cir. Bras.. Publicado em: 2017-01
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6. Estragole blocks neuronal excitability by direct inhibition of Na+ channels
Estragole is a volatile terpenoid, which occurs naturally as a constituent of the essential oils of many plants. It has several pharmacological and biological activities. The objective of the present study was to investigate the mechanism of action of estragole on neuronal excitability. Intact and dissociated dorsal root ganglion neurons of rats were used to
Braz J Med Biol Res. Publicado em: 02/12/2013
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7. Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion
Frogs have been used as an alternative model to study pain mechanisms. Since we did not find any reports on the effects of sciatic nerve transection (SNT) on the ultrastructure and pattern of metabolic substances in frog dorsal root ganglion (DRG) cells, in the present study, 18 adult male frogs (Rana catesbeiana) were divided into three experimental groups:
Braz J Med Biol Res. Publicado em: 24/05/2013
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8. Modulação da atividade dos canais de sódio dependentes de voltagem e de canais TRPV1 por (-)-Carvona
Among the natural products with experimentally proven analgesic properties, the monoterpernes are of great importance, recognized as the main chemical constituents of essential oils from aromatic plants. ()-Carvone is an example of monoterpene with antinociceptive properties, founded as the main active constituent of oils from some species of the genus Menth
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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9. Avaliação do papel da 5-hidroxitriptamina (5-HT) no processamento periférico da resposta nociceptiva
5-Hydroxytryptamine (5-HT, serotonin) is a cell-derived vasoactive amine, released primarily by platelets (in humans), mast cells (in rodents) and endothelial cells. It is a regulator of smooth muscle in the cardiovascular and gastrointestinal systems, an enhancer of platelet aggregation, and a neurotransmitter in the central nervous system. Although 5-HT is
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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10. Estudo das alterações eletrofisiológicas produzidas pelo estragol sobre os axônios do nervo ciático e os neurossomas do gânglio da raiz dorsal de ratos / Study of electrophysiological changes produced by estragole on the sciatic nerve axons and the neurossomas the dorsal root ganglion of rats
Estragol (EST) é usado como aromatizante na indústria de alimentos e cosméticos. Este é um constituinte natural de vários óleos essenciais de muitas plantas do Nordeste do Brasil. Ele apresenta muitas ações biológicas como: anestésica, hipotérmica, antimicrobiana, miorrelaxante e antiespasmódica. Neste estudo, nós verificamos o efeito do estrago
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/07/2009
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11. Purification, Biochemical and Electrophysiological Characterization of the Toxin Mic6c7NTX from the Micrurus ibiboboca (Merrem, 1820) / Purificação, caracterização bioquímica e eletrofisiológica da toxina Mic6c7NTX da Peçonha da Serpente Micrurus ibiboboca (Merrem, 1820)
Snake venoms contain a complex arsenal of protein bio-active components, many of these being neurotoxins (NTXs). These snakes have high neurotoxic activity venom, corresponding to the Elapidae family, which includes coral snakes (Micrurus) whose venom contains circa 90-95% of low molecular mass protein components. Among these, several are postsynaptic neurot
Publicado em: 2008
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12. Efeito diferencial do veneno do escorpião Tityus bahiensis em correntes de sódio sensíveis e resistentes a tetrodotoxina em neurônios dos Gânglios da Raiz Dorsal de Ratos.
In this study, we tested the effects of Tityus bahiensis scorpion venom on sodium currents recorded from the cell bodies of rat dorsal root ganglion neurons using the whole-cell patch clamp technique. In control conditions, sodium current inactivation at 0 mV exhibited two kinetic components, one fast (tau = 2.15 ± 0.18 ms) and one slow (tau = 13.19 ± 3 ms
Publicado em: 2007