Double Helix
Mostrando 1-12 de 618 artigos, teses e dissertações.
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1. Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the doub
J. Braz. Chem. Soc.. Publicado em: 2021-07
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2. The performance of the (U+Th)/He thermochronology laboratory at UNESP Rio Claro, Brazil
We have developed the first laboratory for (U-Th-Sm)/He thermochronology measurements in South America. Helium is measured using a high-sensitivity magnetic sector mass spectrometer (GVI-Helix-SFT) and a double focusing single collector inductively coupled plasma mass spectrometer (Thermo Scientific ELEMENT2) is used for U, Th and Sm determinations. Repeated
An. Acad. Bras. Ciênc.. Publicado em: 21/03/2019
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3. Sustentação de corrente utilizando campos magnéticos viajantes helicoidais / Helical traveling wave current drive
Entre os diferentes métodos alternativos à indução, para sustentação e/ou geração de corrente em plasmas confinados magneticamente, com o objetivo de se obter o funcionamento contínuo de um possível reator de fusão, foi estudado aquele associado a campos magnéticos viajantes produzidos por bobinas helicoidais alimentadas por correntes de radiofre
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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4. As controvérsias a respeito da participação de Rosalind Franklin na construção do modelo da dupla hélice
Em The double helix, James Watson narra sua versão da construção do modelo da dupla hélice do DNA, na qual indica que Rosalind Franklin, física especialista em cristalografia de raios X, desenvolveu trabalhos empíricos fundamentais para a construção do modelo de Watson e Crick. O relato de Watson dá origem a um problema historiográfico: por que Fra
Scientiae Studia. Publicado em: 2010-03
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5. A trama da vida
On the basis of the knowledges are fragmented and placed in watertight compartments, this thesis proposes that art, by its transdisciplinary characteristics, may contribute to bridging, to make reconnections, entanglement. The complex thinking is the inspiration and literature was the method chosen to shows this possible dialogue. The narrative is woven by f
Publicado em: 2010
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6. Evolução da cadeia de suprimentos na indústria de produtos e soluções para redes de computadores: estudo de múltiplos casos / Supply-chain evolution in the network industr y: multiple cases study
This thesis studies the process and mechanisms of Supply-Chain changes in fast clockspeed industries, focusing the cyclical movements toward vertical integration and horizontal disintegration, according to Charles Fines Double Helix model. Other elements, derivate or inductors from these changes have also been studied such as outsourcing activities, growing
Publicado em: 2008
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7. Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis inhibition), inherently reactive agents (DNA alkylating electrophilic traps for macromolecular nucleophile
Química Nova. Publicado em: 2005-02
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8. Relaxação em sistemas moleculares complexos / Relaxation in complex molecular systems
In this Thesis are presented studies by Molecular Dynamics simulations on some molecular systems presenting complex dynamics behavior (i.e., relaxation process caracterized by multiple time scales), including saccharides aqueous solutions, double helix DNA systems, air/water interfaces containing surfactants, and supercooled water. These systems, although cl
Publicado em: 2005
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9. Double-helix current drive revisited
The conditions required for efficient current drive in a weakly resistive plasma column, subject to a double helix traveling magnetic field, are examined in detail by using a simple non-linear Ohm's law for the plasma. In agreement with previous numerical work on the subject by Bertram [5], it is shown that field penetration is indeed strongly limited when l
Brazilian Journal of Physics. Publicado em: 2003-12
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10. Pesquisa de ligação do hycanthone a sitios cromatinicos com diferente supra-organização, composição e função
Hycanthone is a drug used for the clinical trials of schistossomiasis, although inducing chro mosome breaks when it enters the DNA double helix . In this work the binding of hycanthone to chromatin areas dif fering in terms of composition and phisyology, was inves tigated. Based on visual observation of nu clear basophilia and anisotropy a preferential bindi
Publicado em: 1984
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11. Estudos cariologicos em celulas de camundongos apos tratamento com oxamniquine
With the aim of evaluating the effect of oxamniquine, a drug used in the clinical trials of schistosomiasim mannsoni, the patterns of nuclear basophilia and anisotropy of the chromatin of hepatocytes, cardiac muscle and lymphocytes of young adult mice were studies. The mice received the dru orally in a single dose of 436 mg/kg and were bleeded at different i
Publicado em: 1981
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12. Helical growth of Bacillus subtilis: a new model of cell growth.
A multiple mutant of Bacillus subtilis that grows in an unusual double-helix morphology was studied. Construction of models led to the assumption that cell surface elongation must proceed in a helical path in this mutant. The observation that all newly formed double-helix clones propagated, after spore outgrowth in fluid culture, consisted of closed-circular