Draize Test
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Determination of eye irritation potential of low-irritant products: comparison of in vitro results with the in vivo draize rabbit test
In an attempt to build the evaluation strategies to assess the human eye irritation, a reassessment of some in vitro tests is necessary, particularly concerning the non-irritants, mild and moderate irritants. Thus, the correlations between results obtained from the Draize test with the in vitro methods HET-CAM (Hens Egg Test-Chorion Allantonic Membrane) and
Brazilian Archives of Biology and Technology. Publicado em: 2012-06
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2. A Reassessment of the in vitro total protein content determination (TPC) with SIRC and 3T3 cells for the evaluation of the ocular irritation potential of shampoos: comparison with the in vivo Draize rabbit test
The aim of this work was to determine the correlation between results obtained from the Draize test and from the Total Protein Content Determination (TPC) to assess the ocular irritancy potential of 20 shampoos. For TPC, two established cell lines (SIRC and 3T3) were used. The concentration that induced 50% inhibition relative to controls (IC50) was calculat
Brazilian Archives of Biology and Technology. Publicado em: 2011-12
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3. Alterações na superfície ocular de coelhos tratados com formulações do herbicida ácido diclorofenoxiacético (2,4 d), utilizando a graduação do teste ocular de draize
Ocular irritation test is required by the Brazilian government authorities during the registration process of pesticide products, and it is essential for its toxicological classification. The present study evaluated the clinical and microscopic changes in the eye surface of rabbits after treatment with four pesticide formulations containing the herbicide 2,4
Publicado em: 2007
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4. In vitro citotoxicity test as an alternative to in vivo Draize test for the evaluation of cosmetic / Teste de citotoxicidade in vitrocomo alternativa ao teste in vivode Draize na avaliação de produtos cosméticos
The procedures described by Draize are the basis of both ocular and cutaneous irritation tests and have been adopted internationally for in vivo evaluation of products and substances. However, they have been criticized for ethical reasons, due to their cruelty towards animals. Therefore, alternative methodologies are being studied to evaluate the toxicity of
Publicado em: 2003
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5. Development of Microsponges for Topical Delivery of Mupirocin
The goal of the present study was to develop and evaluate microsponge-based topical delivery system of mupirocin for sustained release and enhanced drug deposition in the skin. Microsponges containing mupirocin were prepared by an emulsion solvent diffusion method. The effect of formulation and process variables such as internal phase volume and stirring spe
Springer US.