Drg Neurons
Mostrando 1-12 de 75 artigos, teses e dissertações.
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1. Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury
Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by high-throughput Illumina HiSeq2500 sequencing to profile t
Braz J Med Biol Res. Publicado em: 26/07/2018
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2. Restoration of sensory dysfunction following peripheral nerve injury by the polysaccharide from culinary and medicinal mushroom, Hericium erinaceus (Bull.: Fr.) Pers. through its neuroregenerative action
Abstract Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. We investigated the ability of polysaccharide from Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crus
Food Sci. Technol. Publicado em: 24/11/2015
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3. Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion
Frogs have been used as an alternative model to study pain mechanisms. Since we did not find any reports on the effects of sciatic nerve transection (SNT) on the ultrastructure and pattern of metabolic substances in frog dorsal root ganglion (DRG) cells, in the present study, 18 adult male frogs (Rana catesbeiana) were divided into three experimental groups:
Braz J Med Biol Res. Publicado em: 24/05/2013
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4. Modulação da atividade dos canais de sódio dependentes de voltagem e de canais TRPV1 por (-)-Carvona
Among the natural products with experimentally proven analgesic properties, the monoterpernes are of great importance, recognized as the main chemical constituents of essential oils from aromatic plants. ()-Carvone is an example of monoterpene with antinociceptive properties, founded as the main active constituent of oils from some species of the genus Menth
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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5. Papel do receptor P2X3 e da ativação da proteína kinase C épsilon dos neurônios nociceptivos periféricos na dor inflamatória / Role of P2X3 receptor and PKC epsilon activation of peripheral nociceptive neurons on inflammatory pain
Enquanto a hiperalgesia inflamatória depende da liberação de prostaglandinas e/ou de aminas simpatomiméticas que sensibilizam os neurônios aferentes primários, nosso grupo demonstrou recentemente que o bloqueio do receptor P2X3 no tecido periférico previne a hiperalgesia induzida pela carragenina.. No entanto, o mecanismo pelo qual a ativação dos re
Publicado em: 2010
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6. Purification, Biochemical and Electrophysiological Characterization of the Toxin Mic6c7NTX from the Micrurus ibiboboca (Merrem, 1820) / Purificação, caracterização bioquímica e eletrofisiológica da toxina Mic6c7NTX da Peçonha da Serpente Micrurus ibiboboca (Merrem, 1820)
Snake venoms contain a complex arsenal of protein bio-active components, many of these being neurotoxins (NTXs). These snakes have high neurotoxic activity venom, corresponding to the Elapidae family, which includes coral snakes (Micrurus) whose venom contains circa 90-95% of low molecular mass protein components. Among these, several are postsynaptic neurot
Publicado em: 2008
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7. Caracterização da atividade antinociceptiva de peptídeos homólogos ao C-terminal da proteína S100A9 murina. Ação sobre neurônios sensoriais via canais de cálcio dependentes de voltagem do tipo N / Characterization of the antinociceptive effect of peptides homologous to the C-terminus of murine S100A9 protein. Effects on sensory neurons, via type-N voltage-dependent calcium channels
O peptídeo idêntico ao C-terminal da proteína S100A9 murina (pS100A9mH92-G110) inibe a hiperalgesia inflamatória induzida pela carragenina. Em adição, este peptídeo inibe a hiperalgesia inflamatória induzida por tripsina, uma serino protease capaz de ativar receptores ativados por protease do tipo 2 (PAR2). O objetivo inicial deste trabalho foi carac
Publicado em: 2006
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8. Ação do N-acetilmuramil-L-alanil-D-isoglutamina (MDP) na regeneração nervosa periférica. Estudo experimental em camundongos / N-acetylmuramyl-L-alanyl-D-isoglutamine on peripheral nerve regeneration. Experimental study in mice
N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) was evaluated for its effect on the regenerating peripheral neurons in adult animals. The left sciatic nerve of nine male adult mice C57BL/6J was cut, the proximal and distal nerve stumps were inserted into a polyethylene tube (PT) with 0,76 mm inner diameter, leaving a four mm distance gap. Animals were randomly
Publicado em: 2003
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9. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy
Spinal sensory (dorsal root ganglion; DRG) neurons display slowly inactivating, tetrodotoxin-resistant (TTX-R), and rapidly inactivating, TTX-sensitive (TTX-S) Na currents. Attenuation of the TTX-R Na current and enhancement of TTX-S Na current have been demonstrated in cutaneous afferent DRG neurons in the adult rat after axotomy and may underlie abnor
The National Academy of Sciences of the USA.
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10. Selective expression of endogenous lactose-binding lectins and lactoseries glycoconjugates in subsets of rat sensory neurons.
Cell-surface glycoconjugates and endogenous lectins have been implicated in cellular interactions that contribute to embryonic development. Functional subsets of primary sensory neurons in mammalian dorsal root ganglia (DRG) have been shown recently to express specific cell-surface oligosaccharide structures. We report here that endogenous lectins with affin
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11. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion
Neuronal hyperexcitability in both injured and adjacent uninjured neurons is associated with states of chronic injury and pain and is likely subject to neuroinflammatory processes. Chronic inflammatory responses are largely orchestrated by chemokines. One chemokine, monocyte chemoattractant protein-1 (MCP-1), in the presence of its cognate receptor, the β c
National Academy of Sciences.
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12. Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture.
Target-dependent cell death of different sub-populations of sensory neurons may be regulated by different trophic factors. To investigate this possibility, we have taken advantage of the fact that the fractions of muscle sensory and cutaneous sensory neurons in chicken dorsal root ganglia (DRG) are probably different at different segmental levels, and we hav