Drug Excipients Interaction
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded
Quím. Nova. Publicado em: 2020-06
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2. Optimization of controlled release primaquine diphosphate tablets / Otimização da liberação de difosfato de primaquina em comprimidos de liberação controlada
The objective of the present work was to produce primaquine diphosphate controlled release tablets based on hydrophilic polymers and use the mixture statistical experimental design (DOE) to optimize drug release. In selecting the components of the formulations, differential scanning calorimetry (DSC) were carried out to verify the compatibility between drug/
Publicado em: 2009
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3. Estudos de correlaÃÃo de parÃmetros tÃrmicos e de dissoluÃÃo do fluconazol na caracterizaÃÃo tecnolÃgica de desintegrantes
The real need to develop, to produce and to market drugs with high quality level, allied the diversity of products pharmaceutical resultant of different synthesis and purification processes, do one of the improvement of the control of quality of the raw materials of the great challenges of the pharmaceutical industries. The present work studies the correlati
Publicado em: 2008
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4. Estudo termoanalítico e de compatibilidade fármaco-excipiente de rifampicina e alguns medicamentos utilizados na terapêutica da tuberculose / Thermoanalytical study and drug-excipient compatibility of rifampicin and some medicines utilized in tuberculosis terapeutics
This work was aimed at implementing the thermal analysis and other physico-chemical and analytical techniques in the development and quality control of drugs and medicines for the treatment of tuberculosis, especially rifampicin. The differential scanning calorimetry (DSC), thermogravimetry/derivative thermogravimetry(TG/DTG), elemental analysis, X-ray diffr
Publicado em: 2007
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5. Avaliação de interações do ácido gálico frente a adjuvantes empregados em formas farmacêuticas sólidas / Evaluation of the interacion of gallic acid and pharmaceutical excipients employed in solid dosage forms
Neste trabalho foram avaliados o comportamento do ácido gálico e de adjuvantes tecnológicos frequentemente empregados em formas farmacêuticas sólida, e das suas misturas físicas, através de métodos termoanalíticos e por espectroscopia de infravermelho. Foi investigada também a influência da compactação sobre as misturas físicas equiponderais. O
Publicado em: 2007
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6. Halofantrine poly-&-caprolactone nanocapsules: development, characterization and cardiotoxicity study / NANOCÁPSULAS DE POLI--CAPROLACTONA CONTENDO HALOFANTRINO: DESENVOLVIMENTO, CARACTERIZAÇÃO E ESTUDO DA CARDIOTOXICIDADE.
Malaria is one of the worlds most important parasitic infections. Severe malaria is one of complicated form of Plasmodium falciparum infection which intravenous antimalarial drug administration is always necessary. In this case, the halofantrine (Hf) could be a good alternative for treatment of severe malaria because it is highly active against drug resistan
Publicado em: 2006
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7. A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates
The purpose of this study was to evaluate the nature of film formation on tablets with different compositions, using confocal laser scanning microscopy (CLSM), and to measure film adhesion via the application of a novel “magnet probe test”. Three excipients, microcrystalline cellulose (MCC), spray-dried lactose monohydrate, and dibasic calcium phosphate
Springer-Verlag.
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8. The protective effect of lactose on lyophilization of CNK-20402
The goal of this research was to assess the feasibility of using lyophilization to stabilize an exploratory compound, CNK-20402, with a minimal amount of impurity (CNK-20193) formation. A mixed-level full factorial experimental design was used to screen excipients of glycine, mannitol, lactose monohydrate, and povidone K-12. Cryostage microscopy, powder X-ra
Springer-Verlag.
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9. Effect of Plasticizer on Release Kinetics of Diclofenac Sodium Pellets Coated with Eudragit RS 30 D
The present study was designed to investigate the effect of two plasticizers, i.e., triethyl citrate (TEC) and polyethylene glycol 6000 (PEG 6000) on the in vitro release kinetics of diclofenac sodium from sustained-release pellets. Ammonio methacrylate copolymer type B (Eudragit RS 30 D) is used as the release-retarding polymer. Both plasticizers were used
Springer US.
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10. Spray-dried mucoadhesive microspheres: Preparation and transport through nasal cell monolayer
The purpose of this research was to prepare spray-dried mucoadhesive microspheres for nasal delivery. Microspheres composed of hydroxypropyl methylcellulose (H), chitosan (CS), carbopol 934P (CP) and various combinations of these mucoadhesive polymers, and maltodextrin (M), colloidal silicon dioxide (A), and propylene glycol (P) as filler and shaper, were pr
Springer-Verlag.