Drug Research
Mostrando 1-12 de 632 artigos, teses e dissertações.
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1. Silver complexes for tuberculosis treatment: a short review
This paper is a brief review of silver complexes that have been identified as antibacterial drugs with promising use for the treatment of tuberculosis (TB). This treatment aims to cure and discontinue the transmission of the disease. The excessive and inappropriate use of drugs has jeopardized the effectiveness of antibiotics for the TB treatment, bringing b
Química Nova. Publicado em: 2022
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2. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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3. Adverse effects associated with favipiravir in patients with COVID-19 pneumonia: a retrospective study
ABSTRACT BACKGROUND: Favipiravir is generally used in treating coronavirus disease 2019 (COVID-19) pneumonia in Turkey. OBJECTIVE: To determine the side effects of favipiravir and whether it is a good treatment option. DESIGN AND SETTING: Retrospective study conducted in Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Tur
Sao Paulo Medical Journal. Publicado em: 2022
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4. Internationalization of China’s medical device industry: a case study in Brazil
Abstract Purpose The singularity of being the first Chinese manufacturer of drug-eluting stents to arrive in Brazil and the country being selected as the company's first experience outside its home country motivated the interest in the study of this case, vis-à-vis with the characteristic of internationalization medical device companies according to the Up
RAUSP Management Journal. Publicado em: 2022
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5. Three-dimensional cell culture for the study of nasal polyps
Abstract Objectives: Three-dimensional (3D) cell cultures have many applications such as stem cell biology research, new drug discovery, cancer, and Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). This disease is characterized by a significant impact on quality of life and productivity. The diversity of factors that act in the progression of CRSwNP point
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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6. Long-term effects of antipsychotics on mortality in patients with schizophrenia: a systematic review and meta-analysis
Objective: To gather current evidence on the impact of antipsychotics on long-term mortality in patients with schizophrenia. Methods: We systematically searched for articles in Embase, PubMed, and PsycINFO reporting the long-term mortality (follow-up > 1 year) of patients with schizophrenia who were using any antipsychotics. We then conducted multiple meta-
Brazilian Journal of Psychiatry. Publicado em: 2022
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7. Which is the best way of using nitrous oxide for treatment and research in neuropsychiatry?
Objective: Whether for spiritual, recreational, or potential therapeutic use, interest in ayahuasca has grown remarkably. Ayahuasca’s main active substances are N,N‐dimethyltryptamine and certain monoamine oxidase inhibitor β-carbolines. Possible drug interactions are a major concern, and research is lacking in this area. The objective of this study wa
Braz. J. Psychiatry. Publicado em: 2021-08
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8. Risk assessment of ayahuasca use in a religious context: self-reported risk factors and adverse effects
Objective: Whether for spiritual, recreational, or potential therapeutic use, interest in ayahuasca has grown remarkably. Ayahuasca’s main active substances are N,N‐dimethyltryptamine and certain monoamine oxidase inhibitor β-carbolines. Possible drug interactions are a major concern, and research is lacking in this area. The objective of this study wa
Braz. J. Psychiatry. Publicado em: 2021-08
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9. Editorial Comment: Are three-day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort
ABSTRACT Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice. Materials and Methods: A review of the scientific literature was performed using a combination of specific descriptors (side effect, adverse effect, scopolamine, sildenafil, tadalafil, vardenafil, oxybutynin, tolterodine, spironolactone,
Int. braz j urol.. Publicado em: 2021-08
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10. Convalescent plasma therapy - a silver lining for COVID-19 management?
ABSTRACT The COVID-19 pandemic has pushed the world towards social, economic, and medical challenges. Scientific research in medicine is the only means to overcome novel and complex diseases like COVID-19. To sum up the therapeutic wild-goose chase, many available antivirals and repurposed drugs have failed to show successful clinical evidence in patient rec
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
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11. Anais Brasileiros de Dermatologia: 2021-2025 Term. Work and Challenges
Abstract The technological advancement of the pharmaceutical industry, resulting from the techniques of molecular biology and expansion of the knowledge of immunopathogenesis, has modified the therapeutic arsenal used in dermatology. Scientific research and regulatory standards cause drug costs to rise, thus making their use impossible in most public policie
An. Bras. Dermatol.. Publicado em: 2021-03
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12. Socioeconomic impact of high-cost drugs in Brazilian dermatology. Legal and financial aspects, and impact on clinical practice
Abstract The technological advancement of the pharmaceutical industry, resulting from the techniques of molecular biology and expansion of the knowledge of immunopathogenesis, has modified the therapeutic arsenal used in dermatology. Scientific research and regulatory standards cause drug costs to rise, thus making their use impossible in most public policie
An. Bras. Dermatol.. Publicado em: 2021-03