Drug Residue
Mostrando 1-12 de 150 artigos, teses e dissertações.
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1. Multivariate Optimization Applied to the Synthesis of Meglumine Antimoniate with Low Levels of Trivalent Antimony
Meglumine antimoniate (MA) is a pentavalent antimony (SbV) drug recommended for the treatment of leishmaniasis. It is known that the trivalent antimony (SbIII) present as a residue in MA contributes to the drug side effects. In this article, multivariate optimization was used in the synthesis of MA in order to obtain a drug with low levels of SbIII. Four var
J. Braz. Chem. Soc.. Publicado em: 2021-08
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2. SIMPLE AND FAST DETERMINATION FOR GAMMA-HYDROXYBUTYRATE (GHB) IN URINE SAMPLE BY LLE AND GC-MS
Gamma-hydroxybutyrate (GHB) is a depressant of the central nervous system able to promote disinhibition, anterograde amnesia and its use is related to Drug-Facilitated Crimes (DFC). Urine is the biological matrix of choice for toxicological analysis in victims of rape and/or theft in suspected victims of DFC. The aim of this work was the development of a sim
Quím. Nova. Publicado em: 2021-02
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3. Avermectins residues in milk produced in the state of Pernambuco
Abstract Milk is a food widely consumed by the population, so it is important that it has adequate hygienic conditions and is free of chemical contaminants from various sources. This study aimed to evaluate the occurrence of avermectin residues in milk produced in the state of Pernambuco. The collections were performed in the dry and rainy season, being coll
Food Sci. Technol. Publicado em: 2020-12
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4. EXTRACTION OF MONOMERS OF HYDROLYSABLE TANNINS FROM PODS OF Libidibia ferrea (Mart. ex Tul.) L. P. QUEIROZ: EFFECTS OF SOLVENT AND AMOUNT OF DRUG USING RESPONSE-SURFACE METHODOLOGY AND DESIRABILITY PROFILE
In this study was evaluated the influence of the extraction factors on the extract’s properties to improve the recovery of high concentrations of the phytochemicals important for the biological activities from pods of Libidibia ferrea (Mart. ex Tul.) L. P. Queiroz. The extracts were obtained by turbo-extraction and a factorial design 32 was used to study t
Quím. Nova. Publicado em: 2020-06
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5. Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegrad
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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6. Milk quality parameters associated with the occurrence of veterinary drug residues in bulk tank milk
ABSTRACT Veterinary drug residues in bulk tank milk are important to all sectors of the dairy chain because they are one of the major factors which determine the safety of the final product. This study attempted to identify milk quality parameters that are associated with the occurrence of veterinary drug residues using multivariate principal component analy
Sci. agric. (Piracicaba, Braz.). Publicado em: 2017-06
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7. Planejamento de inibidores baseado em fragmentos moleculares para a enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi / Design of inhibitors through fragment-based drug discovery for the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi
Chagas disease is a parasitic illness endemic in Latin America caused by the trypanosomatid parasite Trypanosoma cruzi that spreads around the world due to people migration. Nowadays, Benznidazole and Nifurtimox (banned in Brazil), are used for the treatment of this disease but causes severe side effects to patients. Recently, three new molecules have reache
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/04/2012
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8. Desenvolvimento de métodos cromatográficos hifenados (in-tube SPME/LC-FLD e GCxGC/qMS) para análises de fármacos e agrotóxicos em amostras complexas / Development of hyphenated chromatographic methods (in-tube SPME/LC-FLD and GCxGC/MS) for analysis of drugs and pesticides in complex samples.
Determination of trace levels of drugs in biological fluids and multiresidue (contaminants) in food samples is extremely important because this generates valuable data for therapeutic drug monitoring (individualization of dosage regimen) and quality control (food safety), respectively. Because of the demand for analytical methods with high resolution and low
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2011
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9. Identification and antimicrobial resistance of microflora colonizing feral pig (Sus scrofa) of Brazilian Pantanal
Antimicrobial resistance of bacteria is a worldwide problem affecting wild life by living with resistant bacteria in the environment. This study presents a discussion of outside factors environment on microflora of feral pigs (Sus scrofa) from Brazilian Pantanal. Animals had samples collected from six different body sites coming from two separated geographic
Brazilian Journal of Microbiology. Publicado em: 2011-06
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10. Technological development of aqueous extracts from Calycophyllum spruceanum (Benth.) Hook. f. ex K. Schum., Rubiaceae, (mulateiro) using factorial design
The aim of the present work is to characterize the vegetal raw material of the Calycophyllum spruceanum (Benth.) Hook. f. ex K. Schum., Rubiaceae, known as "mulateiro", and to evaluate the influence of extractive parameters for attainment of standardized aqueous extractive solutions. The physical-chemical characterization of the samples was performed using p
Revista Brasileira de Farmacognosia. Publicado em: 04/03/2011
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11. DEVELOPMENT AND STANDARDIZATION OF Rapanea ferruginea MEZ. (MIRSINACEAE) DRY EXTRACT OBTAINED FROM SPRAY DRYING AND EVALUATION IN VIVO OF ITS ANTINOCICEPTIVE ACTIVITY / DESENVOLVIMENTO E PADRONIZAÇÃO DE EXTRATO SECO DE Rapanea ferruginea MEZ. (MIRSINACEAE) OBTIDO POR SPRAY DRYING E AVALIAÇÃO IN VIVO DA ATIVIDADE ANTINOCICEPTIVA
Rapanea ferruginea is a pantropical species that grows in various parts of Brazil. It is popularly known in Brazil as canela-azeitona or capororoca. Studies carried out in past by the NIQFAR research group have shown that this plant presents biological effects, including antiinflamatory, hypoglicemic and analgesic effects. This work seeks to develop and stan
Publicado em: 2010
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12. Desenvolvimento e validação de metodos analititicos para a deteminação de residuos de estreptomicina e diidroesteptominicina em leite bovino (ELISA, LC-APCI-MS/MS QToF) / Development and validation of analytical methos for the determination of streptomycin and ddihydrostreptomycin residues in milk (ELISA, LC-APCI-MS/MS QToF)
Veterinary drugs pose a risk to human health when there residual levels in foods exceed the maximum residue limit (MRL). Knowledge of the extent of human exposure to these compounds is necessary to provide consumer protection. To achieve this, it is essential that validated analytical methods are available to ensure reliable results. The aim of the present w
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/07/2009