Drugs Toxicity Mortality
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil
Resumo O Cerrado brasileiro possui diversas espécies botânicas com fins medicinais utilizadas por comunidades tradicionais e muitas dessas plantas não estão incluídas na lista do Programa de Pesquisa de Plantas Medicinais da Central de Medicamentos. O objetivo deste estudo foi a triagem fitoquímica e o bioensaio toxicológico frente ao Brine shrimp L.
Braz. J. Biol.. Publicado em: 21/10/2019
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2. Fluconazole prophylaxis in preterm infants: a systematic review
ABSTRACT Objective: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis. Methods: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The key
Braz J Infect Dis. Publicado em: 2017-06
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3. Previous use of quinolones: a surrogate marker for first line anti-tuberculosis drugs resistance in HIV-infected patients?
OBJECTIVES: Drug resistant Mycobacterium tuberculosis causes much higher rates of treatment toxicity, failure or relapse, and mortality. We determined the drug resistant profile of Mycobacterium tuberculosis strains isolated from a population of HIV-infected patients in southern Brazil and studied the potential factors associated with resistance. METHODS: We
Brazilian Journal of Infectious Diseases. Publicado em: 2012-04
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4. The allogeneic and autologous hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission: analyses of 62 patients / O transplante de células tronco hematopoéticas alogênico e autogênico na leucemia mielóide aguda em primeira remissão completa: análise de 62 pacientes
O transplante de células tronco hematopoéticas alogênico e autogênico na leucemia mielóide aguda em primeira remissão completa: analise de 62 pacientes. Os pacientes foram submetidos a transplante de células tronco hematopoéticas alogênico e autogênico. Ao final do estudo estavam vivos no alogênico 43,3% e no autogênico 62,5%. Consolidação inte
Publicado em: 2008
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5. Efficacy of amphotericin B in a fat emulsion for the treatment of cryptococcal meningitis in AIDS patients
Several formulae have been developed in an attempt to reduce the toxicity of amphotericin B (AmB), but their high costs preclude widespread use. The aim of this study was to evaluate the efficacy of amphotericin B in a fat emulsion, i.e. Intralipid (AmB-IL), in 37 AIDS patients with cryptococcal meningitis (CM). We retrospectively reviewed data collected in
Brazilian Journal of Infectious Diseases. Publicado em: 2007-04
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6. Caracterização morfofuncional da ototoxicidade por cisplatina em ratos: avaliação do papel da apoptose e da otoproteção por amifostina / Morfofuncional characterization of the ototoxicidade for cisplatina in rats: evaluation of the paper of apoptose and the otoproteção for amifostina
Cisplatin (cis-diamminedicloroplatinum) is an antineoplastic drug frequently used in the treatment of a variety of cancers, specially the head-and-neck cancer. Ototoxicity, however, has been noted as a common side-effect of cisplatin, which may lead to significant interruptions in treatment, possibly impacting on local tumor control and patient survival. The
Publicado em: 2006
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7. Vegetables products active against microbiological agents: particularly methodological studies of action against Trypanosoma cruzi / PRODUTOS VEGETAIS ATIVOS CONTRA AGENTES MICROBIANOS: ESTUDOS METODOLÓGICOS PARTICULARES DE AÇÃO CONTRA Trypanosoma cruzi.
The use of medicinal plants in the world, and especially in South America, contributes significantly to primary health care. Several plants are used in Brazil in the form of crude extracts, infusions or plasters to treat common infectious without any scientific evidence of efficacy.In this study extracts of 5 species of plants from Amazon region were screene
Publicado em: 2005
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8. Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data
BMJ.
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9. Perspective on hypertension in the elderly.
More than half of elderly men and women have hypertension, leading to a significant risk of increased morbidity and mortality. The cause of hypertension in this age group is unknown. Left ventricular hypertrophy is frequently present, often associated with diastolic dysfunction. Systolic hypertension in the elderly increases the risk of cardiovascular diseas
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10. Efficacy, toxicity, and pharmacokinetics of pentoxifylline and its analogs in experimental Staphylococcus aureus infections.
Pentoxifylline (PTX), a drug that improves neutrophil function in vitro, has been shown to protect neonatal mice against death from experimental staphylococcal infection in vivo at a dose of 50 mg/kg. Using a total of 774 neonatal mice, the effects of various doses of PTX were examined and compared with the effects of three analogs: HWA-448, HWA-285, and A81
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11. Chemical Control of Cancer
Improvement of the present mortality from cancer depends upon a means of controlling those cancers that have spread from the original site to distant organs. Killing of tumor cells by means of drugs, whether used by themselves or in combination with surgery or irradiation, provides the strategy most likely to achieve this goal in the near future. There are n
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12. Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models
Adverse drug reactions (ADRs) present a serious human health problem. They are major contributors to hospitalization and mortality throughout the world (Lazarou et al., 1998; Pirmohamed et al., 2004). A small fraction (less than 5%) of ADRs can be classified as “idiosyncratic.” Idiosyncratic ADRs (IADRs) are caused by drugs with diverse pharmacological e
The American Society for Pharmacology and Experimental Therapeutics.