Dystrophin
Mostrando 1-12 de 227 artigos, teses e dissertações.
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1. Three days of intermittent stretching after muscle disuse alters the proteins involved in force transmission in muscle fibers in weanling rats
The aim of this study was to determine the effects of intermittent passive manual stretching on various proteins involved in force transmission in skeletal muscle. Female Wistar weanling rats were randomly assigned to 5 groups: 2 control groups containing 21- and 30-day-old rats that received neither immobilization nor stretching, and 3 test groups that rece
Braz J Med Biol Res. Publicado em: 04/12/2015
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2. Immobilization and therapeutic passive stretching generate thickening and increase the expression of laminin and dystrophin in skeletal muscle
Extracellular matrix and costamere proteins transmit the concentric, isometric, and eccentric forces produced by active muscle contraction. The expression of these proteins after application of passive tension stimuli to muscle remains unknown. This study investigated the expression of laminin and dystrophin in the soleus muscle of rats immobilized with the
Braz J Med Biol Res. Publicado em: 2014-06
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3. Mecanismos de proteção da distrofia muscular : estudo proteômico e terapia farmacológica / Protective mechanisms of muscular dystrophy : proteomic study and pharmacological therapy
In Duchenne Muscular Dystrophy (DMD) and in the mdx mice model of DMD, the lack of dystrophin leads to muscle degeneration. The pathogenesis of DMD is related to sarcolemmal fragility, mechanical stress and increased influx of calcium in muscle fibers, due to dysfunction of ion channels, such as the stretch-activated calcium channels. The knowledge of the pr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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4. Estudo de proteínas relacionadas ao costâmero em secções longitudinais de músculo sóleo de ratas imobilizadas e reabilitadas pelo alongamento passivo manual intermitente / Study of costameric proteins in soleus muscle longitudinal sections of female rats immobilized and rehabilitated by intermittent passive manual stretching
The interface between sarcolemma and extracellular matrix in skeletal muscle tissue is constituted by specialized proteins that are responsible for the transversal and longitudinal forces transmission to the myofiber. Skeletal muscle adaptations to physiological and pathological forces, such as segmental immobilization and rehabilitation exercises, may contr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/06/2012
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5. Efeito do ômega-3 em músculos de animais distróficos da linhagem mdx / Effect of omega-3 in dystrophic muscle of mdx mice
In Duchenne muscular dystrophy (DMD) and in the mdx mice model of DMD, absence of dystrophin promotes instability of the sarcolemma and progressive muscle degeneration. The inflammatory process contributes significantly to the pathophysiology of the disease. Anti-inflammatory steroids are widely used for DMD therapy. However, due to its ineffective action an
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/03/2012
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6. Efeito do ácido eicosapentaenoico na necrose e inflamação dos músculos distróficos de camundongos mdx / Effects of eicosapentaenoic acid on myonecrosis and inflammation in dystrophin-deficient muscles of the mdx mice
Na distrofia muscular de Duchenne e no camundongo mdx a proteína distrofina está ausente ou é expressa de forma não funcional. Com isso, o complexo distrofina-glicoproteínas se desorganiza, a fibra muscular se torna frágil durante os ciclos de contração e relaxamento muscular, as concentrações intracelulares de cálcio e radicais livres se elevam,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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7. Psychophysical measurements of luminance and chromatic spatial and temporal contrast sensitivity in Duchenne muscular dystrophy
In children with Duchenne muscular dystrophy, color vision losses have been related to dystrophin deletions downstream of exon 30, which affect a dystrophin isoform, Dp260, present in the retina. To further evaluate visual function in DMD children, we measured spatial, temporal, and chromatic red-green and blue-yellow contrast sensitivity in two groups of DM
Psychology & Neuroscience. Publicado em: 2011-06
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8. Alterations of morphology, mechanical and osteogenic capacity of mdx mice bones / Alterações da morfologia, resistência mecânica e capacidade osteogênica dos ossos de camundongos mdx
Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by lack of dystrophin. DMD patients have brittle bones because of muscle weakness and use of glucocorticoids. The mdx mouse is widely used as experimental model for the study of DMD and it presents lack of dystrophin, intense inflammatory process and muscle fiber degeneration. Moreover, it p
Publicado em: 2011
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9. Phenotypic and immunohistochemical characterization of sarcoglycanopathies
INTRODUCTION: Limb-girdle muscular dystrophy presents with heterogeneous clinical and molecular features. The primary characteristic of this disorder is proximal muscular weakness with variable age of onset, speed of progression, and intensity of symptoms. Sarcoglycanopathies, which are a subgroup of the limb-girdle muscular dystrophies, are caused by mutati
Clinics. Publicado em: 2011
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10. Avaliação neuropsicológica em crianças com distrofia muscular de Duchenne, acompanhadas no ambulatório de doenças neuromusculares do Hospital das Clínicas da Universidade Federal de Minas Gerais
Objective: to revise the literature on the neuropsychological evaluation and presence of ADHD in children and young adults with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) and the correlation between cognitive functions and genetic factors. Source of data: A nonsystematic bibliographic review, for the period 1966-2010, using PubMed/
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2010
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11. Avaliação neuropsicológica de pacientes com distrofia muscular de Duchenne / Neuropsychological assessment of patients with Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is caused by mutations in the dystrophin gene. This gene codes for dystrophin, a protein important for maintaining the stability of muscle-fiber membranes. The objectives of the study were to examine neuropsychological performance in patients with DMD and the influence of deletions in the dystrophin gene (the Dp140 regulator
Publicado em: 2009
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12. Influência da distrofia muscular do Golden Retriever (GRMD) na viabilidade espermática e nas características morfológicas do aparelho reprodutivo masculino / Influence of Golden Retriever muscular dystrophy (GRMD) on sperm viability and on morphologic characteristics of the male reproductive tract
Muscular dystrophies constitute a group of diseases characterized by progressive and irreversible muscle degeneration. Duchenne´s Muscular Dystrophy (DMD) is a lethal myopathy caused by dystrophin deficiency, a muscular cell cytoskeleton protein. The dystrophin gene have recessive characteristic and is located in the p21 portion of the X chromosome. Advance
Publicado em: 2009