Ectoenzymes
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. EFEITOS DO RESVERATROL, DO SUCO DE UVA E DO VINHO TINTO NOS BIOMARCADORES DE ESTRESSE OXIDATIVO E NA ATIVIDADE DE ECTOENZIMAS EM RATOS DIABÉTICOS / EFFECTS OF RESVERATROL, GRAPE JUICE AND RED WINE ON BIOMARKERS OF OXIDATIVE STRESS AND ON ECTOENZYMES ACTIVITY IN DIABETIC RATS
O diabetes mellitus (DM) é um dos maiores problemas de saúde pública no mundo. A hiperglicemia crônica presente no estado diabético está associada com um aumento do estresse oxidativo, o qual tem sido apontado por ter um papel central no desenvolvimento e na progressão de complicações diabéticas. Alterações na morfologia e função das plaquetas
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/11/2012
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2. Modelo de regulação dos nucleotídeos extracelulares no líquido superficial das vias respiratórias
Extracellular nucleotides play a key role in the regulation of mucociliary clearance and thus are essential in protecting the airways against inhaled pathogens. Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) nucleotides are secreted by the respiratory epithelium to the airway surface liquid, where they are metabol
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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3. PROFILET OF THE ECTONUCLEOTIDASE ACTIVITY AND PLATELETS AGREGGATION IN SYSTEMIC ERYTHEMATOSUS LUPUS PATIENTS / PERFIL DA ATIVIDADE DE ECTONUCLEOTIDASES EM PLAQUETAS E AGREGAÇÃO PLAQUETÁRIA EM PACIENTES COM LÚPUS ERITEMATOSOS SISTÊMICO
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that affects mostly women in reproductive age and sometimes cause permanent damage. The development of cardiovascular disease, especially atherosclerosis, is the leading cause of death in SLE. However, its etiology and relationship with the development of atherosclerosis remain unknown. Sev
Publicado em: 2010
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4. Brain ischemia alters platelet ATP disphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats
The effects of transient forebrain ischemia, reperfusion and ischemic preconditioning on rat blood platelet ATP diphosphohydrolase and 5'- nucleotidase activities were evaluated. Adult Wistar rats were submitted to 2 or 10 min of single ischemic episodes, or to 10 min of ischemia 1 day after a 2-min ischemic episode (ischemic preconditioning) by the four-ves
Publicado em: 2010
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5. Avaliação da atividade de nucleotidases e parâmetros de estresse oxidativo em pacientes com esclerose múltipla e em modelo experimental de desmielinização em ratos
A esclerose múltipla (EM) é a principal doença desmielinizante do sistema nervoso central (SNC), sendo considerada a principal causa de incapacidade neurológica em adultos jovens. Além das alterações imunes, neurológicas e vasculares que são encontradas na EM, tem sido postulado que o estresse oxidativo pode estar envolvido na patogênese desta doen
Publicado em: 2009
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6. Avaliação da participação das ecto-nucleotidases do Trypanosoma cruzi nos processos de infecção e virulência em modelo murino
Chagas disease is one of the main diseases with high economical and social impacts in Latin America, with millions of people with this illness. The current drugs used to treat this disease lead to low cure, especially in the chronic phase and present high toxic non- desired side effects. Because of these there are necessity to develop new drugs and strategie
Publicado em: 2008
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7. Brain ischemia alters platelet ATP diphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats
The effects of transient forebrain ischemia, reperfusion and ischemic preconditioning on rat blood platelet ATP diphosphohydrolase and 5'-nucleotidase activities were evaluated. Adult Wistar rats were submitted to 2 or 10 min of single ischemic episodes, or to 10 min of ischemia 1 day after a 2-min ischemic episode (ischemic preconditioning) by the four-vess
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-11
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8. NEW EMBO MEMBER’S REVIEW: Cell surface monoamine oxidases: enzymes in search of a function
Ectoenzymes with a catalytically active domain outside the cell surface have the potential to regulate multiple biological processes. A distinct class of copper-containing semicarbazide-sensitive monoamine oxidases, expressed on the cell surface and in soluble forms, oxidatively deaminate primary amines. Via transient covalent enzyme–substrate intermediate
Oxford University Press.
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9. NEW EMBO MEMBER’S REVIEW: Functional aspects of protein mono-ADP-ribosylation
Mono-ADP-ribosylation is the enzymatic transfer of ADP-ribose from NAD+ to acceptor proteins. It is catalysed by cellular ADP-ribosyltransferases and certain bacterial toxins. There are two subclasses of cellular enzymes: the ectoenzymes that modify targets such as integrins, defensin and other cell surface molecules; and the intracellular enzymes that act o
Oxford University Press.
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10. Alteration of alveolar macrophage functions after aerosol infection with bovine herpesvirus type 1.
Calves were aerosol challenged with bovine herpesvirus type I, and bronchoalveolar cells were subsequently retrieved by lavage from days 1 to 8 postinfection. Alveolar macrophages (AM), which were depleted of contaminating cells, were characterized with respect to phenotypic markers and functional activities. In most aspects, the changes suggested a stimulat
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11. Generation and Characterization of Ecto-ADP-Ribosyltransferase ART2.1/ART2.2-Deficient Mice
This is the first study reporting the inactivation of a member of the mouse gene family of toxin-related ecto-ADP-ribosyltransferases (ARTs). Transfer of the ADP-ribose moiety from NAD onto extracellular arginine residues on T-cell membrane proteins is mediated by glycosylphosphatidylinositol-linked cell surface ARTs. Exposure of T cells to ecto-NAD blocks T
American Society for Microbiology.
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12. Extracellular ATP is a mitogen for 3T3, 3T6, and A431 cells and acts synergistically with other growth factors.
Extracellular ATP in concentrations of 5-50 microM displayed very little mitogenic activity by itself but it caused synergistic stimulation of [3H]thymidine incorporation in the presence of phorbol 12-tetradecanoate 13-acetate, epidermal growth factor, platelet-derived growth factor, insulin, adenosine, or 5'-(N-ethyl)carboxamidoadenosine. Cultures of Swiss