Effector
Mostrando 1-12 de 3155 artigos, teses e dissertações.
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1. lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer
Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. Here, we demonstrated that lncRNA OIP5-AS1 was upregula
Braz J Med Biol Res. Publicado em: 2020-01
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2. EFEITO DO PARASITISMO POR Haemonchus contortus SOBRE O METABOLISMO OXIDATIVO DE LEUCÓCITOS DE OVINOS
Resumo A resposta imune tardia direcionada para eliminação da hemoncose pode ser modulada pelo perfil Th2, sendo os eosinófilos as principais células efetoras responsáveis pela eficiente eliminação do parasita; ou modulada pelo perfil Th1, sendo os neutrófilos as principais células efetoras, que promovem eliminação parasitária mais deficiente, po
Ciênc. anim. bras.. Publicado em: 13/12/2019
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3. Anti-complement activity in salivary glands and midgut of Chagas disease vector, Panstrongylus megistus (Hemiptera, Triatominae)
ABSTRACT The triatomine insect Panstrongylus megistus , one of the most important Chagas disease vectors in Brazil, presents salivary molecules pharmacologically active to counteract homeostatic responses from the host, including inhibitors of the human complement system, a major effector of immune responses. The aim of the present study was to investigate t
Rev. Inst. Med. trop. S. Paulo. Publicado em: 08/08/2019
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4. Detection of virulence genes in Salmonella Heidelberg isolated from chicken carcasses
ABSTRACT During the last years, Brazilian government control programs have detected an increase of Salmonella Heidelberg in poultry slaughterhouses a condition that poses a threat to human health However, the reasons remain unclear. Differences in genetic virulence profiles may be a possible justification. In addition, effective control of Salmonella is rela
Rev. Inst. Med. trop. S. Paulo. Publicado em: 22/07/2019
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5. An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis
Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disease models was the development of gene editing technique
Braz J Med Biol Res. Publicado em: 25/04/2019
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6. Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro
Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling pathway. Sema3 proteins convey their regulatory signals by binding to neuropilins and plexins receptors, wh
Braz J Med Biol Res. Publicado em: 08/10/2018
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7. Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection
Trypanosoma cruzi triggers a progressive inflammatory response affecting cardiovascular functions in humans and experimental models. Angiotensin II, a key effector of the renin-angiotensin system, plays roles in mediating hypertension, heart failure, and inflammatory responses. T. cruzi and AngII can induce inflammatory responses by releasing inflammatory me
Braz J Med Biol Res. Publicado em: 26/03/2018
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8. Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene
Abstract The human C-C chemokine receptor type-5 (CCR5) is the major transmembrane co-receptor that mediates HIV-1 entry into target CD4+ cells. Gene therapy to knock-out the CCR5 gene has shown encouraging results in providing a functional cure for HIV-1 infection. In gene therapy strategies, the initial region of the CCR5 gene is a hotspot for producing fu
Genet. Mol. Biol.. Publicado em: 19/03/2018
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9. Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
Abstract: Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TN
An. Bras. Dermatol.. Publicado em: 2018-03
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10. Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed.
Braz J Med Biol Res. Publicado em: 16/02/2017
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11. The role of intradermal proliferation of T-cells in the pathogenesis of psoriasis
Abstract: BACKGROUND: Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evid
An. Bras. Dermatol.. Publicado em: 2017-02
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12. Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune response
Abstract: The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an infected human host. Accumulating evidence suggests that M
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-02