Eicosanoids
Mostrando 1-12 de 128 artigos, teses e dissertações.
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1. Montelukast Has no Impact on the Systemic Production of TGFβ-1 in Patients with Nasal Polyposis Associated with Aspirin Intolerance
Abstract Introduction Nasal polyposis is a disease characterized by a mechanical dysfunction of the nasal mucosa, closely related to the unique makeup of its extracellular matrix, which develops as the result of an anomalous tissue remodeling process. Transforming growth factor beta 1 (TGF-β1) is reduced not only in the nasal polypoid tissue, but also in
Int. Arch. Otorhinolaryngol.. Publicado em: 2021-01
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2. Eicosanoids and cancer
Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and inflammatory responses. In recent years, studies have shown the importance of eicosanoids in the control of physiol
Clinics. Publicado em: 09/08/2018
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3. Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion
Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown. Plasmodium berghei-infected mosquitoes were injected with an eicosanoid biosynthesis inhibitor, indomethacin (IN), or a substrate, arachidonic acid (AA), at day 7 or day 12 post-infection (p.i.). Salivary gland i
Mem. Inst. Oswaldo Cruz. Publicado em: 19/08/2014
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4. Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms
The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population pres
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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5. Characterization of the inflammatory reaction induced by Bothrops insularis snake venom: leukocyte influx, release of inflammatory mediators and mechanisms involved in this effects / Caracterização da reação inflamatória induzida pelo veneno da serpente Bothrops insularis: Influxo leucocitário, liberação de mediadores inflamatórios e mecanismos envolvidos nesses efeitos
In this study the effects of Bothrops insularis venom (BiV) on the leukocyte influx, on the circulating leukocyte numbers and release of mediators, such as PGD2, PGE2, TXA2, LTB4, MCP-1 and KC into the local of its injection. Moreover, the role of eicosanoids in the BiV- induced leukocyte influx was assessed by selected pharmacological treatments. PMN were a
Publicado em: 2010
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6. Ureases display biological effects independent of enzymatic activity. Is there a connection to diseases caused by urease-producing bacteria?
Ureases are enzymes from plants, fungi and bacteria that catalyze the hydrolysis of urea to form ammonia and carbon dioxide. While fungal and plant ureases are homo-oligomers of 90-kDa subunits, bacterial ureases are multimers of two or three subunit complexes. We showed that some isoforms of jack bean urease, canatoxin and the classical urease, bind to glyc
Publicado em: 2010
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7. Planejamento, síntese e avaliação farmacológica de novos candidatos a protótipos de fármacos anti-inflamatários, desenhados a partir do nerolidilcatecol / Planning, synthesis and pharmacological evaluation of new candidates for prototypes of anti-inflamatários, drawn from the nerolidylcatechol
Inflammation is a local reaction of tissue involving neurological, vascular, humoral and cellular reactions to eliminate the causal agents and reduce the cellular damages. Prostaglandins, thromboxanes and leukotrienes are examples of chemical inflammation mediators, resulting for the action of the enzyme phospholipase A2 (PLA2). The PLA is a enzyme that hydr
Publicado em: 2009
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8. The supplementation with fatty poliinsaturated omega-3 acids reduced the plasmatic concentration of pro-inflammatory eicosanoids of the lactate desidrogenase enzyme and muscular lesions in rats submitted to sessions of swimming. / A suplementação com acidos graxos polinsaturados omega-3 reduziu a concentração plasmatica de eicosanoides pro-inflamatorios, da enzima lactato desidrogenase e de lesões musculares em ratos submetidos a sessões de natação.
The use of antiinflammatory drugs is common among athletes in which the prevalence of muscular lesions is elevated in training and competition periods. However, some of those drugs have an immunosuppression action, and when used in high dosages or for long time can provoke a decrease in the immunological responses. The objective of the present Thesis was to
Publicado em: 2007
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9. Participation of galectin-1 in the evolution of experimental histoplasmosis / Participação da galectina-1 na evolução da histoplasmose experimental
Galectin-1 (Gal-1) belongs an endogenous lectins family that recognizes -galactoside and participates of various biological activities. This lectin can modulate the innate and adaptative immune responses. Although, Gal-1 participates of various pathophysiological processes, in literature we did not find reports related to the participation of Gal-1 in fungal
Publicado em: 2007
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10. Estudo da modulação de corpúsculos lipídicos em células epiteliais. / Study of the modulation of lipid bodies in epithelial cells.
Corpúsculos lipídicos (CLs) são inclusões citoplasmáticas compostas principalmente por triglicerídeos e ésteres de colesterol, sendo também depósitos intracelulares de ácido araquidônico (AA) que pode ser metabolizado para a formação de eicosanóides. A PGE2 é o principal metabólito da via do AA produzido por células epiteliais. É um potente
Publicado em: 2007
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11. Arachidonic acid triggers an oxidative burst in leukocytes
The change in cellular reducing potential, most likely reflecting an oxidative burst, was investigated in arachidonic acid- (AA) stimulated leukocytes. The cells studied included the human leukemia cell lines HL-60 (undifferentiated and differentiated into macrophage-like and polymorphonuclear-like cells), Jurkat and Raji, and thymocytes and macrophages from
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-11
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12. Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients
Lipids used in nutritional support of surgical or critically ill patients have been based on soybean oil, which is rich in the n-6 fatty acid linoleic acid (18:2n-6). Linoleic acid is the precursor of arachidonic acid (20:4n-6). In turn, arachidonic acid in cell membrane phospholipids is the substrate for the synthesis of a range of biologically active compo
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-04