Endogenous Nitric Oxide Synthase Inhibitors
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. Stress-induced neuroinflammation: mechanisms and new pharmacological targets
Stress is triggered by numerous unexpected environmental, social or pathological stimuli occurring during the life of animals, including humans, which determine changes in all of their systems. Although acute stress is essential for survival, chronic, long-lasting stress can be detrimental. In this review, we present data supporting the hypothesis that stres
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
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2. Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis
We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recov
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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3. Effect of simvastatin, alpha-tocopherol and L-arginin on the endogenous nitric oxide synthase inhibitors, nitric oxide metabolites and thiols in hypercholesterolemic patients / Efeito da sinvastatina, alfa-tocoferol e L-arginina sobre os inibidores endógenos da óxido nítrico sintase, metabólitos do óxido nítrico e tióis em pacientes hipercolesterolêmicos
The aim of this study was to evaluate the effect of sinvastatin, isolated and associated to α-tocopherol and to L-arginine, on the endogenous inhibitors of nitric oxide synthase, on nitric oxide metabolytes and thiols, in hypercholesterolemic patients. A group of 16 hypercholesterolemic patients were analysed, acconting to the protocol: a washout period
Publicado em: 2002
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4. Identificação da enzima oxido nitrico sintase em vegetais
The enzyme nitric oxide synthase (NOS) is responsible for the synthesis of nitric oxide (NO), from the oxidation of L-arginine to L-citrulline. This enzyme has been found largely distributed in nature. In the animal kingdom, the NOS isoforms constitutively expressed are frequently Ca2+ -dependent and involved in physiological processes while Ca2+ -independen
Publicado em: 1999
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5. Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats.
Because the kidneys are vasodilated and the endogenous production of nitric oxide is increased in gravid rats, we tested whether nitric oxide mediates the renal vasodilatory response to pregnancy. Chronically instrumented, conscious rats of gestational days 12-14 were studied concurrently with age-matched virgin control animals. GFR and effective renal plasm
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6. Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase.
We have examined the effects of modulating nitric oxide (NO) levels on osteoclast-mediated bone resorption in vitro and the effects of nitric oxide synthase (NOS) inhibitors on bone mineral density in vivo. Diaphorase-based histochemical staining for NOS activity of bone sections or highly enriched osteoclast cultures suggested that osteoclasts exhibit subst
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7. Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro.
Human airway smooth muscle possesses an inhibitory nonadrenergic noncholinergic neural bronchodilator response mediated by nitric oxide (NO). In guinea pig trachea both endogenous NO and vasoactive intestinal peptide (VIP) modulate cholinergic neural contractile responses. To identify whether endogenous NO or VIP can modulate cholinergic contractile response
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8. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.
We evaluated the effects of nitric oxide (NO) generators and endogenous production of NO elicited by substance P (SP) in the angiogenesis process. Angiogenesis was monitored in the rabbit cornea in vivo and in vitro by measuring the growth and migration of endothelial cells isolated from coronary postcapillary venules. The angiogenesis promoted in the rabbit
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9. Neuronal (type I) nitric oxide synthase regulates nuclear factorκB activity and immunologic (type II) nitric oxide synthase expression
Nitric oxide subserves diverse physiologic roles in the nervous system. NO is produced from at least three different NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS, and immunologic NOS (iNOS). We show that nNOS is the predominant isoform constitutively expressed in glia. NO derived from nNOS in glia inhibits the transcription factor nuclear
The National Academy of Sciences of the USA.
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10. Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice
Nitric oxide (NO) derived from the inducible isoform of NO synthase (iNOS) is an inflammatory product implicated both in secondary damage and in recovery from brain injury. To address the role of iNOS in experimental traumatic brain injury (TBI), we used 2 paradigms in 2 species. In a model of controlled cortical impact (CCI) with secondary hypoxemia, rats w
American Society for Clinical Investigation.
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11. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
Antagonists of glutamate receptors of the N-methyl-d-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting a clinical opportunity for the use of NMDAR antagonists and NOS inhibitors in chronic pain. Agmatine (AG), an endogenous neuromodulator
The National Academy of Sciences.
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12. Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells
To investigate whether caveolin-1 (cav-1) may modulate inducible nitric oxide synthase (iNOS) function in intact cells, the human intestinal carcinoma cell lines HT29 and DLD1 that have low endogenous cav-1 levels were transfected with cav-1 cDNA. In nontransfected cells, iNOS mRNA and protein levels were increased by the addition of a mix of cytokines.
The National Academy of Sciences.