Endostatin
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. Primary tumorectomy promotes angiogenesis and pulmonary metastasis in osteosarcoma-bearing nude mice
PURPOSE: To investigate the effect of primary tumorectomy on angiogenesis and pulmonary metastasis in osteosarcoma-bearing nude mice. METHODS: Osteosarcoma was introduced to nude mice via subcutaneous injection of MG-63 cells. One hundred and eighty osteosarcoma-bearing mice were used equally in 3 parallel experiments. The effect of tumorectomy (TR) on the e
Acta Cir. Bras.. Publicado em: 2013-03
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2. Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors
OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional polymorphism p.D104N impairs the activity of endostatin, resulting in a decreased ability to inhibit angiogenesis. This polymorphism h
Clinics. Publicado em: 2012
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3. Avaliação do vetor retroviral bicistrônico Codificador de endostatina e interleucina-2 Para utilização em terapia gênica anti-tumoral. / Evaluation of retroviral vector encoding bicistônico of endostatin and interleukin-2 for use in anti-tumor gene therapy
Gene therapy has been used in preclinical studies and clinical trials in order to assuage or cure a disease. Retroviral vectors are tools for gene transfer are widely used. Bicistronic vectors are attractive alternatives for treatment of complex disease. Endostatin (ES), the C-terminal fragment of collagen XVIII, is a potent angiogenesis inhibitor. At presen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2010
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4. Construção e caracterização in vitro de um vetor retroviral bicistrônico codificando endostatina e interleucina-2 para utilização em terapia gênica / Construction and chracterization in vitro of a bicistronic retroviral vector coding endostatin and interleukin-2 for use in gene therapy
A terapia gênica tem sido empregada em estudos pré-clínicos e clínicos, com o intuito de amenizar ou curar uma doença. Vetores retrovirais são uma ferramenta de transferência gênica largamente utilizada. Vetores bicistrônicos são uma alternativa interessante para o tratamento de doenças complexas. Na construção de um vetor bicistrônico pode-se
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/12/2009
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5. Collagen XVIII/endostatin expression in experimental endotoxemic acute renal failure
Acute renal failure (ARF) is a frequent complication of Gram-negative sepsis, with a high risk of mortality. Lipopolysaccharide (LPS)-induced ARF is associated with hemodynamic changes that are strongly influenced by the overproduction of nitric oxide (NO) through the cytokine-mediated up-regulation of inducible NO synthase. LPS-induced reductions in systemi
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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6. Terapia antiangiogênica de tumores utilizando células produtoras de endostatina encapsuladas em dispositivos de imunoisolamento / ANTIANGIOGENIC THERAPY USING ENDOSTATIN PRODUCER CELLS ENCAPSULATED IN IMMUNOISOLATION DEVICES.
Endostatin is a specific inhibitor of endothelial cell proliferation, migration and a potent angiogenesis inhibitor. It has been shown that continuous administration of endostatin is more effective in tumor suppression than the same dose administered s.c. daily. Achieving concentration of endostatin to combat tumor growth is complicated by the short life of
Publicado em: 2008
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7. OBTAINING HIGH SERUM LEVELS OF MURINE ENDOSTATIN IN MICE USING RECOMBINANT CHINESE HAMSTER OVARY CELLS SECRETING ENDOSTATIN TRANSPLANTED IN IMUNOISOLATION DEVICES / Terapia cecular em camundongos utilizando células CHO secretoras de endostatina transplantadas em dispositivos de imunoisolamento
Endostatina, um fragmento do colágeno XVIII de 20 kDa, é um potente inibidor de angiogênese e crescimento tumoral. Foi previamente demonstrado que a administração contínua de endostatina em modelos animais melhorou a eficácia e potência da terapia antitumoral, comparada com a administração subcutânea diária por injeções de endostatina. A libera
Publicado em: 2008
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8. "Estudo funcional do colágeno tipo XVIII" / Functional study of the type XVIII collagen
A síndrome de Knobloch (SK) é uma doença autossômica recessiva rara, caracterizada por problemas oculares e presença de encefalocele occipital, porém o quadro clínico é variável. Os pacientes apresentam principalmente miopia de grau elevado, degeneração vítreo-retiniana e descolamento de retina; o grau de comprometimento da alteração no occipit
Publicado em: 2006
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9. Interaction of endostatin with integrins implicated in angiogenesis
Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with α5- and αv-integrins on the surface of human endothelial cells. We further demonstrate tha
The National Academy of Sciences.
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10. E-selectin is required for the antiangiogenic activity of endostatin
Endostatin, a 20-kDa fragment of collagen XVIII, is a potent angiogenesis inhibitor. E-selectin, an inducible leukocyte adhesion molecule specifically expressed by endothelial cells, has also been implicated in angiogenesis. By using in vivo, ex vivo, and in vitro angiogenic assays, we investigated the functional relationship between endostatin and E-selecti
National Academy of Sciences.
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11. Molecular Interplay between Endostatin, Integrins, and Heparan Sulfate*
Endostatin is an endogenous inhibitor of angiogenesis. Although several endothelial cell surface molecules have been reported to interact with endostatin, its molecular mechanism of action is not fully elucidated. We used surface plasmon resonance assays to characterize interactions between endostatin, integrins, and heparin/heparan sulfate. α5β1 and αvβ
American Society for Biochemistry and Molecular Biology.
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12. The First Draft of the Endostatin Interaction Network*
Endostatin is a C-terminal proteolytic fragment of collagen XVIII that is localized in vascular basement membrane zones in various organs. It binds to heparin/heparan sulfate and to a number of proteins, but its molecular mechanisms of action are not fully elucidated. We have used surface plasmon resonance (SPR) arrays to identify new partners of endostatin,
American Society for Biochemistry and Molecular Biology.