Endothelium Physiology
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Avaliação hemodinâmica e da função endotelial em mulheres jovens normotensas em uso de anticoncepcional hormonal combinado oral contendo drospirenona / Assessment of hemodynamic and endothelial function in normotensive young women using a combined hormonal oral contraceptive containing drospirenone
Importância. Anticoncepcionais hormonais combinados orais (AHCO) podem levar ao aumento do risco da doença cardiovascular, que pode estar associado a alterações na pressão arterial e na função endotelial. Objetivos. O objetivo deste estudo foi avaliar o impacto do uso de AHCO contendo 20 mg de etinilestradiol (EE) e 3 mg de drospirenona (DRSP) por mul
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/10/2011
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2. Evaluation of myocardial perfusion reserve in severe hypercholesterolemic patients with real time contrast echocardiography, before and after treatment with HMG-CoA reductase inhibitors / Estudo da reserva de perfusão miocárdica pelo ecocardiograma com contraste em tempo real, em indivíduos com hipercolesterolemia grave, antes e após tratamento com inibidores da HMG-CoA redutase
INTRODUÇÃO: A hipercolesterolemia provoca alterações inflamatórias no sistema cardiovascular, induzindo disfunção endotelial e mudanças estruturais na microcirculação, com alterações significativas da homeostase vascular, processo este reversível com o tratamento hipolipemiante. Clinicamente, tais fenômenos podem ser demonstrados pela avaliaç�
Publicado em: 2009
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3. Time-dependent characterization of vascular reactivity in aorta of a2A and a2C-adrenoceptors knockout mice. / Avaliação temporal da função vascular em aorta de camundongos com deleção dos receptores a2A e a2BC adrenérgicos.
Este estudo avaliou a função vascular em anéis de aorta e no leito vascular mesentérico (LVM) de camundongos com deleção dos receptores a2A e a2Cadrenérgicos (KO) com 3, 5 e 7 meses, os quais apresentam uma hiperatividade simpática acompanhada de cardiomiopatia. Os KO apresentaram um aumento da freqüência car
Publicado em: 2007
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4. "Função endotelial em adultos jovens com infarto do miocárdio. Influências ambientais e genéticas" / Endothelium function in young adults with myocardial infarction
A disfunção endotelial atua tanto na aterogênese como na precipitação das síndromes coronárias agudas. A redução da biodisponibilidadedo óxido nítrico é expressão de endotélio disfuncional. O mecanismo desta redução não está elucidado. A presença de disfunção endotelialfoi correlacionada com fatores de risco (FR), nitrato sanguíneo e fa
Publicado em: 2005
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5. Robert F. Furchgott, Nobel laureate (1916–2009) – a personal reflection
Robert F. Furchgott, pharmacologist and joint winner of the Nobel Prize for Medicine or Physiology (1998) died on the 12th of May 2009 aged 92. By unlocking the astonishingly diverse biological actions of nitric oxide, Furchgott leaves behind a rich legacy that has both revolutionized our understanding of human physiology and stimulated new and exciting oppo
Blackwell Publishing Ltd.
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6. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.
In hypercholesterolemic rabbits, oral L-arginine (the substrate for endothelium derived nitric oxide) attenuates endothelial dysfunction and atheroma formation, but the effect in hypercholesterolemic humans is unknown. Using high resolution external ultrasound, we studied arterial physiology in 27 hypercholesterolemic subjects aged 29+/-5 (19-40) years, with
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7. Endothelium-dependent contractions and endothelial dysfunction in human hypertension
The endothelium is a crucial regulator of vascular physiology, producing in healthy conditions several substances with a potent antiatherosclerotic properties. Accordingly, the presence of endothelial dysfunction is associated with subclinical atherosclerosis and with an increased future risk of cardiovascular events. A large body of evidence supports the fu
Blackwell Publishing Ltd.
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8. The TRANSPARENT TESTA12 Gene of Arabidopsis Encodes a Multidrug Secondary Transporter-like Protein Required for Flavonoid Sequestration in Vacuoles of the Seed Coat Endothelium
Phenolic compounds that are present in the testa interfere with the physiology of seed dormancy and germination. We isolated a recessive Arabidopsis mutant with pale brown seeds, transparent testa12 (tt12), from a reduced seed dormancy screen. Microscopic analysis of tt12 developing and mature testas revealed a strong reduction of proanthocyanidin deposition
American Society of Plant Physiologists.
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9. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.
Neuropathologic studies of AIDS patients have shown that brain capillary endothelial cells are a cellular target for human immunodeficiency virus (HIV) in vivo. We have established in vitro cultures of primary human brain capillary endothelial (HBCE) cells. Using this model system, we have shown a significant HIV infection of HBCE cells that is productive ye
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10. Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
The generation of mice lacking specific components of the transforming growth factor-β (TGF-β) signal tranduction pathway shows that TGF-β is a key player in the development and physiology of the cardiovascular system. Both pro- and anti-angiogenic properties have been ascribed to TGF-β, for which the molecular mechanisms are unclear. Here we report that
Oxford University Press.
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11. Endothelial cell diversity revealed by global expression profiling
The vascular system is locally specialized to accommodate widely varying blood flow and pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the lumens of blood and lymphatic vessels play an integral role in the regional specialization of vascular structure and physiology. However, our understanding of EC diversity is
National Academy of Sciences.
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12. Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure
Hypoxic pulmonary vasoconstriction continues to attract interest more than half a century after its original report because of persistent mystery about its biochemical mechanism and its exact physiological function. Recent work suggests an important role for pulmonary arteriolar smooth muscle cell oxygen-sensitive voltage-dependent potassium channels. Inhibi
BioMed Central.