Enteric Coating
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Recobrimento gastrorresistente de pellets de diclofenaco de sódio em leito fluidizado tipo Wurster / Aqueous enteric coating of diclofenac sodium in a fluiidized bed coater column with a Wuster insert
Os pellets apresentam muitas vantagens biofarmacêuticas e são ideais para aplicação de recobrimento. Quando o recobrimento é funcional, um dos principais objetivos é formação de uma barreira que modifique o perfil de liberação da droga (liberação controlada ou gastrorresistente). Neste trabalho pellets de diclofenaco de sódio foram produzidos po
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/02/2012
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2. Development and evaluation of a hot-melt coating technique for enteric coating
O revestimento entérico convencional requer o uso de polímeros orgânicos os quais são igualmente danosos ao meio ambiente e ao pessoal que o executa. O revestimento por fusão a quente evita o uso de solventes e é processo mais seguro e que consome menos tempo. O presente estudo foi planejado para avaliar a eficácia do revestimento por fusão a quente
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2012-03
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3. Enteric coating of ibuprofen tablets (200 mg) using an aqueous dispersion system
Ibuprofeno é um derivado do ácido propiônico, que pertence à classe dos fármacos não-esteróides (AINES). As principais reações adversas associadas com o ibuprofeno se referem àquelas do trato gastrintestinal (TGI), como úlceras pépticas e da mucosa, dispepsia, dor gástrica grave e sangramento, que resultam em muitas falhas de tratamento. O objet
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2010-03
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4. Obtenção de sistemas multiparticulados de isoniazida revestidos com polímero de liberação entérica
Known for thousands of years, tuberculosis (TB) is the leading cause of mortality by a single infectious disease due to lack of patient adherence to available treatment regimens, the rising of multidrug resistant strains of TB (MDR-TB) and co-infection with HIV virus. Isoniazid and rifampicin are the most powerful bactericidal agents against M. tuberculosis.
Publicado em: 2009
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5. Polymeric coating and pharmacokinetic of chitosan granules containing ddI incorporated in microparticles / Revestimento polimerico e farmacocinetica de granulos gastrorresistentes contendo didanosina incorporada em microparticulas de quitosana
This work studied the production and pharmacokinetic of a new pharmaceutical formulation of the didanosine (ddI) drug ,composed by chitosan granules containing ddI incorporated in microparticles, for oral administration in the AIDS therapy. The advantages of this new pharmaceutical formulation compared to the conventional one are: to assure ddI stability in
Publicado em: 2008
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6. Preparação e avaliação de cápsulas gastro-resistentes de diclofenaco de sódio
Cápsulas resistentes ao trato gastrintestinal são freqüentemente usadas com diversos propósitos. Estas cápsulas promovem eficácia farmacológica e farmacocinética de substâncias que são instáveis, ou irritantes para a mucosa gástrica. O diclofenaco de sódio é um antiinflamatório não-esteróide, que, por ser muito utilizado, despertou o interes
Publicado em: 2007
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7. Microparticulas de quitosana com didanosina e sua formulação em granulos mucoadesivos / Didanosine-load chitosan microspheres and their formulation in mucoadhesive granules
In this work a scalable process was developed for the production of gastroresistent granules containing chitosan microspheres, loaded with the drug didanosine (ddl). The global process included three stages, and the operational conditions were optimized in order to maintain the active form of the drug didanosine, which is sensitive to acidic pH conditions, a
Publicado em: 2006
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8. Tecnologia de obtenÃÃo de revestimento aquoso gastro- resistente para comprimidos de bisacodil 5mg - prÃ-formulaÃÃo e desenvolvimento do processo de revestimento
Intestinal constipation is a symptom that affects a large section of the population across the world and has multiple and various causes. For this reason the consumption of laxatives is on the rise. Bisacodyl is, at present, the drug that is most often prescribed for this complaint. As it acts locally and intestinally, bisacodyl can be found in the form of e
Publicado em: 2005
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9. Intestinal absorption of magnesium from food and supplements.
The purpose of this study was to measure magnesium absorption over the wide range of intakes to which the intestine may be exposed from food and/or magnesium-containing medications. Net magnesium absorption was measured in normal subjects after they ingested a standard meal supplemented with 0, 10, 20, 40, and 80 mEq of magnesium acetate. Although absorption
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10. New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy.
Erythromycin and related macrolide antibiotics have recently enjoyed a resurgence of clinical interest. This is a result of activity against organisms which are becoming more prevalent, particularly in immunocompromised hosts and, in addition, better understanding of the unique tissue penetration properties and potential immunomodulating properties of macrol
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11. The use of artificial neural networks for the selection of the most appropriate formulation and processing variables in order to predict the in vitro dissolution of sustained release minitablets
The objective of this work was to apply artificial neural networks (ANNs) to examine the relative importance of various factors, both formulation and process, governing the in-vitro dissolution from enteric-coated sustained release (SR) minitablets. Input feature selection (IFS) algorithms were used in order to give an estimate of the relative importance of
Springer-Verlag.
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12. Expression and Self-Assembly in Baculovirus of Porcine Enteric Calicivirus Capsids into Virus-Like Particles and Their Use in an Enzyme-Linked Immunosorbent Assay for Antibody Detection in Swine
Porcine enteric calicivirus (PEC) causes diarrhea and intestinal lesions in pigs. PEC strain Cowden grows to low to moderate titers in cell culture but only with the addition of intestinal contents from uninfected gnotobiotic pigs (W. T. Flynn and L. J. Saif, J. Clin. Microbiol. 26:206–212, 1988; A. V. Parwani, W. T. Flynn, K. L. Gadfield, and L. J. Saif,
American Society for Microbiology.