1. Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases

Abstract Background: L-amino acid oxidases isolated from snake venoms (SV-LAAOs) are enzymes that have great therapeutic potential and are currently being investigated as tools for developing new strategies to treat various diseases, including cancer and bacterial infections. The main objective of this study was to make a brief evaluation of the enzymatic s

J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019

2. Investigations of Acacia modesta Wall. leaves for in vitro anti-diabetic, proliferative and cytotoxic effects

ABSTRACT The leaves of Acacia modesta Wall. have been shown to possess diverse pharmacological properties. Therefore, we aimed at evaluating anti-diabetic, cytotoxic and proliferative effects of extracts of Acacia modesta Wall. leaves. After evaluating the primary and secondary metabolites, anti-diabetic activity of various extracts was assessed by α-amylas

Braz. J. Pharm. Sci.. Publicado em: 26/07/2018

3. BaltDC: purification, characterization and infrared spectroscopy of an antiplatelet DC protein isolated from Bothrops alternatus snake venom

Abstract Background: Snake venoms are a complex mixture of proteins, organic and inorganic compounds. Some of these proteins, enzymatic or non-enzymatic ones, are able to interact with platelet receptors, causing hemostatic disorders. The possible therapeutic potential of toxins with antiplatelet properties may arouse interest in the pharmacological areas.

J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 08/02/2018

4. Indução do sistema citocromo P450 em linhagens de hepatoma humano para utilização como modelo in vitro no desenvolvimento de fármacos / Induction of cytochrome P450 system in human hepatoma cell lines for using as in vitro model in drug development

In the early development stage of the new drugs, the pharmacological and toxicological properties are critical to define the potential use of the candidate drug. During this stage, several in vitro models systems are employed, including human hepatoma cell lines. However, the main limitation of the use of cell lines as in vitro model is the low expression le

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2012

5. Extratos de Arrabidaea chica (Humb. &Bonpl.) verlot obtidos por processos biotecnológicos: otimização da extração e avaliação farmacológica. / Arrabidaea chica (Humb. &Bonpl.) Verlot extracts obtained by biotechnological processes: extraction optimization and pharmacological evaluation.

Arrabidaea chica Verlot (Bignoniaceae), known as crajiru, produces red pigments used by Brazilian indians as dye and as healing agent. This study has aimed the optimization of phenolic compounds extraction from A. chica and to evaluate its pharmacological activities. Extracts from A. chica were obtained through treatment with xylanases from Bacillus pumilus

Publicado em: 2009

6. Planejamento, síntese e avaliação farmacológica de novos candidatos a protótipos de fármacos anti-inflamatários, desenhados a partir do nerolidilcatecol / Planning, synthesis and pharmacological evaluation of new candidates for prototypes of anti-inflamatários, drawn from the nerolidylcatechol

Inflammation is a local reaction of tissue involving neurological, vascular, humoral and cellular reactions to eliminate the causal agents and reduce the cellular damages. Prostaglandins, thromboxanes and leukotrienes are examples of chemical inflammation mediators, resulting for the action of the enzyme phospholipase A2 (PLA2). The PLA is a enzyme that hydr

Publicado em: 2009

7. Determinação dos mecanismos de ação envolvidos nas atividade antiulcerogenica e antioxidantes de Rhizophora mangle L / Determination of the mechanisms of action in the antiulcerogenic and antioxidant activities of Rhizophora mangle L

The pharmacological research has been focusing on the folk medicine knowledge in order to establish the scientific basis of their pharmacological effects. Nowadays, tannins play a prominent role because of its high antioxidant capacity and, due to the progress made in the analysis and identification of these compounds and their therapeutic possibilities. Amo

Publicado em: 2009

8. Anti-carie and antiproliferative effect of 7-epiclusianone, isolated from Rheedia genus plant / Avaliação das atividades anticarie e antiproliferativa da 7-epiclusianona isolada da planta do genero Rheedia

Considering the great use of plants as medicinal substances in the popular medicine, it is critical to investigate their biological and chemical properties in order to not only help to enhance our understanding of the therapeutic potential of these natural products, but also how to make them more effective pharmacological agents. The enormous biodiversitiy o

Publicado em: 2008

9. Do laboratório ao campo virtual: desenvolvimento de um banco de dados de venenos de serpentes brasileiras e análise computacional de estruturas primárias de fosfolipases A2 / From the laboratory to the virtual field: development of a Brazilian-snake venom database and computational analysis of phospholipase A2 primary structures

Os avanços tecnológicos vêm contribuindo cada vez mais nas áreas biológicas e científicas oferecendo ferramentas computacionais e sistemas específicos que em análise de dados in silico fornecem resultados rápidos e confiáveis. O presente projeto propõe o desenvolvimento de um portal na Internet para instalação e utilização de um banco de dados

Publicado em: 2006

10. UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor

The presence of the P2Y2 (P2U-purinergic) receptor on the apical surface of airway tissue raises the possibility that aerosolized UTP might be used therapeutically to induce Cl− secretion in individuals with cystic fibrosis. However, the duration of the effects of UTP may be limited by enzymatic degradation. We therefore have analyzed the metabolism of UTP

The National Academy of Sciences of the USA.