Ep Receptors Antagonists
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Regulação do CD95L por PGE2 e seu impacto na morte de linfócitos T. / CD95L downregulation by PGE2 and its impact on T lymphocyte death.
Antigen-presenting cells (APCs) control T-cell responses by multiple mechanisms, including the expression of co-stimulatory molecules and the production of cytokines and other mediators that control T-cell proliferation, survival and differentiation. In this present work, it was demonstrated that soluble factor(s) produced by Toll-like receptor (TLR)-activat
Publicado em: 2008
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2. PADRONIZAÇÃO E VALIDAÇÃO DE UM NOVO MODELO DE FEBRE INDUZIDA PELA INJEÇÃO INTRATECAL DE PROSTAGLANDINA E2 EM RATOS JOVENS / CHARACTERIZATION AND VALIDATION OF A NEW FEVER MODEL INDUCED BY THE INTRATHECAL INJECTION OF PROSTAGLANDIN E2 IN YOUNG RATS
The fever response, besides being part of host defense response to infection or inflammation, is associated with discomfort and anxiety and may constitute a risk for febrile seizures in children. Therefore, antipyretic therapy is routinely prescribed for febrile patients. The animal models of fever using the systemic injection of lipopolysaccharide (LPS) and
Publicado em: 2006
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3. Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells.
Prostaglandin E2 (PGE2) is a potent lipid molecule with complex proinflammatory and immunoregulatory properties. PGE2 can shape the immune response by stimulating the production of IgE antibody by B lymphocytes and the synthesis of T-helper type 2 cytokines [e.g., interleukin (IL)-4, IL-10], while inhibiting production of Th1 cytokines (e.g., interferon-gamm
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4. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disorder leading to bone and cartilage destruction. A substantial body of evidence suggests that prostaglandin E2 (PGE2) contributes to the pathogenesis of RA, and nonsteroidal anti-inflammatory drugs, inhibitors of the synthesis of PGE2 and other prostanoids, continue to be used in the treatment of this di
American Society for Clinical Investigation.
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5. The P2Y12 Antagonists, 2-Methylthioadenosine 5′-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels*
ADP plays an integral role in the process of hemostasis by signaling through two platelet G-protein-coupled receptors, P2Y1 and P2Y12. The recent use of antagonists against these two receptors has contributed a substantial body of data characterizing the ADP signaling pathways in human platelets. Specifically, the results have indicated that although P2Y1 re
American Society for Biochemistry and Molecular Biology.