Epidermal Growth Factors Receptors
Mostrando 1-12 de 92 artigos, teses e dissertações.
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1. The role of diet, transforming growth factor alpha and epidermal growth factor receptor in the cell proliferation and differentiation during the postnatal development of the gastric epithelium of rats. / O papel do alimento, do fator de crescimento transformante alfa e do receptor do fator de crescimento epidermal na proliferação e diferenciação celular durante o desenvolvimento pós-natal do epitélio gástrico de ratos.
Early weaning (EW) causes changes in the gastric mucosa, including the increase in cell proliferation and Transforming Growth Factor (TGFa). In the present study, we evaluated the role of this peptide and its receptor EGFR in the control of the gastric growth. 15-d-old rats were divided into two groups: suckling (control) and EW, in which the pups were separ
Publicado em: 2009
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2. Antiulcerogenic effect of Chlorella vulgaris extract / Efeito anti-ulcerogenico do extrato de Chlorella vulgaris
About 10%of the world?s population suffer from peptic ulcer, within this percentage we find thousands of Brazilians. This pathology is caused by an unbalance between the protection and attack mechanisms of the stomach lining, and is the result of the association of various endogenous attack factors (pepsin, acid, bile), exogenous factors pertaining to life s
Publicado em: 2005
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3. Chromatin binding of epidermal growth factor, nerve growth factor, and platelet-derived growth factor in cells bearing the appropriate surface receptors.
We analyzed the uptake and intracellular distribution of 125I-labeled epidermal growth factor, nerve growth factor, and platelet-derived growth factor in different cell lines that express or do not express the respective surface receptors for these factors. After 1 hr of incubation, all three growth factors were detected in the cytoplasmic fraction and in th
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4. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.
Three different human tumor lines in culture, a rhabdomyosarcoma, a bronchogenic carcinoma and a metastatic melanoma, release proteins (transforming growth factors, TGFs) into the medium that confer the transformed phenotype on untransformed fibroblasts. These proteins are acid and heat-stable; produce profound morphologic changes in rat and human fibroblast
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5. Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.
Mannose 6-phosphate, insulin like growth factors I and II (IGF I, IGF II), insulin and epidermal growth factor (EGF) induce a 1.5- to 2-fold increase of mannose 6-phosphate binding sites at the cell surface of human skin fibroblasts. The increase is completed within 10-15 min, is dose and temperature dependent, reversible and transient even in the presence o
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6. In vitro activation of Stat3 by epidermal growth factor receptor kinase
Stat proteins are SH2 domain-containing transcription factors that are activated in cells by various cytokines and growth factors. In the case of cytokines whose receptors lack protein kinase activity, phosphorylation–activation is mediated by members of the JAK family of tyrosine protein kinases. In the case of growth factors whose receptors have int
The National Academy of Sciences of the USA.
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7. Lysosomotropic amines inhibit mitogenesis induced by growth factors.
The stimulation of DNA synthesis by epidermal growth factor, insulin, and serum is inhibited by a variety of alkylamines when present for the duration of the stimulatory preincubation (20-24 hr). These results contradict an earlier report [Maxfield, F. R., Davies, P. J. A., Klempner, L., Willingham, M. C. & Pastan, I. (1979) Proc. Natl. Acad. Sci. USA 76, 57
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8. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for the treatment of these tumors are currently being investigated. Given the growth-inhibiting effects of cannabinoids on gliomas and the wide tissue distribution of the two subtypes of cannabinoid receptors (CB1 and CB2), we studied the potential util
American Society for Clinical Investigation.
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9. Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor.
Regenerative proliferation occurs in the inner-ear sensory epithelial of warm-blooded vertebrates after insult. To determine how this proliferation is controlled in the mature mammalian inner ear, several growth factors were tested for effects on progenitor-cell division in cultured mouse vestibular sensory epithelia. Cell proliferation was induced in the se
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10. Growth factors in lung development and disease: friends or foe?
Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Alter
BioMed Central.
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11. The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
The phosphatidylinositol 3-kinase (PI 3-K) becomes activated when quiescent cells are stimulated with a variety of growth factors. We have microinjected antibodies specific for the p110 alpha subunit of the PI 3-K into quiescent fibroblasts and tested their effect on the ability of growth factors to stimulate exit from quiescence and entry into S phase. The
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12. Growth factors from murine sarcoma virus-transformed cells.
Murine sarcoma virus-transformed mouse fibroblasts produce polypeptide growth factors and release them into serum-free medium. These factors stimulate cells to divide in monolayer cultures and also to form colonies that grow progressively soft agar. Three major peaks of activity are seen, with apparent molecular weights of 25,000, 12,000, and 7000. The sarco