Ergosterol Antagonistas Inibidores
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1. Identification and chromosomal localization of 9 Leishmania (L.) major loci related to resistance against two inhibitors of ergosterol biosynthesis pathway / Identificação e caracterização cromossomal de 9 loci de Leishmania (L.) major relacionados com resistência a inibidores da via de biossíntese do ergosterol
Ergosterol is an important compound responsible to maintain integrity and fluidity of Leishmania spp. membranes. Starting from an overexpression/selection method, our group has isolated nine different loci of L. (L.) major related to resistance against two inhibitors of the ergosterol biosynthesis pathway, Terbinafine (TBF) and Itraconazole (ITZ). Individual
Publicado em: 2008