Esat 6
Mostrando 1-12 de 85 artigos, teses e dissertações.
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1. Characteristic profile of antibody responses to PPD, ESAT-6, and CFP-10 of Mycobacterium tuberculosis in pulmonary tuberculosis suspected cases in Surabaya, Indonesia
Abstract Accurate and rapid diagnostic tools are important aspects of managing tuberculosis (TB) cases appropriately. However, the sensitivity and specificity of diagnostic kits based on immune response such as the tuberculin skin test (TST) and interferon gamma release assay (IGRA) are still debated. Thus, the exploration and assessment of specific biomarke
Braz J Infect Dis. Publicado em: 24/10/2019
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2. Evaluation of the transcriptional immune biomarkers in peripheral blood from Warao indigenous associate with the infection by Mycobacterium tuberculosis
Abstract INTRODUCTION: Biomarkers are critical tools for finding new approaches for controlling the spread of tuberculosis (TB), including for predicting the development of TB therapeutics, vaccines, and diagnostic tools. METHODS: Expression of immune biomarkers was analyzed in peripheral blood cells stimulated and non-stimulated with M. tuberculosis ant
Rev. Soc. Bras. Med. Trop.. Publicado em: 16/05/2019
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3. Teste intradérmico com proteínas recombinantes de Mycobacterium bovis como antígenos em Cavia porcellus
O teste intradérmico para o diagnóstico da tuberculose bovina utiliza derivados proteicos purificados (PPD) de Mycobacterium bovis que são capazes de induzir reações de hipersensibilidade em animais infectados. No entanto, apresenta baixa especificidade devido à ocorrência de reações cruzadas com outras micobactérias. Neste sentido, o objetivo dess
Pesq. Vet. Bras.. Publicado em: 2014-10
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4. Enhanced immune response of a bicistronic DNA vaccine expressing fusion antigen Hsp65-Esat-6 of Mycobacterium Tuberculosis with GM-CSF as a molecular adjuvant
This study aimed to construct a bicistronic DNA vaccine expressing fusion antigen Hsp65-Esat-6 of Mycobacterium tuberculosis with cytokine GM-CSF as a molecular adjuvant (pIRES-Hsp65-ESAT-6-GM-CSF, pIRHEG), and the immune response in mice. C57BL/6 mice were immunized with the recombinant plasmid to detect the titer of antibodies, lymphocyte proliferation, th
Braz. arch. biol. technol.. Publicado em: 2013-10
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5. Evaluation of an enzyme-linked immunospot assay for the immunodiagnosis of atypical spinal tuberculosis (atypical clinical presentation/atypical radiographic presentation) in China
BACKGROUND: Atypical spinal tuberculosis (TB) usually presents in a slowly indolent manner with nonspecific clinical presentations making the diagnosis a great challenge for physicians. New technologies for the detection of atypical spinal TB are urgently needed. The aim of this study was to assess the diagnostic value of an enzyme-linked immunospot (ELISPOT
Braz J Infect Dis. Publicado em: 2013-10
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6. Immunologic evaluation and validation of methods using synthetic peptides derived from Mycobacterium tuberculosis for the diagnosis of tuberculosis infection
The goal of this study was to demonstrate the usefulness of an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of pulmonary tuberculosis (PTB) and extrapulmonary TB (EPTB). This assay used 20 amino acid-long, non-overlapped synthetic peptides that spanned the complete Mycobacterium tuberculosis ESAT-6 and Ag85A sequences. The validation cohor
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-04
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7. Seleção e caracterização de biomarcadores aplicáveis em plataformas nanotecnológicas para o diagnóstico da tuberculose
A tuberculose (TB) é uma doença bacteriana de alta mortalidade, causada pelo Mycobacterium tuberculosis, transmitida pelo doente através das vias respiratórias. A TB é um grave problema de saude pública. Estima-se que um terço da população mundial seja infectada com M. tuberculosis, na forma de infecção latente, que pode assim permanecer por toda
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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8. Investigação de infecção tuberculosa latente em pacientes com psoríase candidatos ao uso de drogas imunobiológicas
O uso dos inibidores do fator de necrose tumoral no tratamento de pacientes com psoríase vem sendo relacionado a uma maior incidência de tuberculose, particularmente, nas suas formas extrapulmonar e disseminada. Apesar de sua indiscutível eficácia, essas drogas elevam o risco da reativação de infecção tuberculosa latente (ITBL), tornando obrigatório
Anais Brasileiros de Dermatologia. Publicado em: 2011-08
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9. Assessment of T-SPOT-TB test for the diagnosis of latent tuberculosis infection in patients with psoriasis / Avaliação do teste T-SPOT.TB no diagnóstico de infecção tuberculosa latente em pacientes com psoríase
Introduction: The therapy for psoriasis was modified by the introduction of immunebiological products that allow better disease control and better quality of life for patients, but promotes increased risk forf latent tuberculosis, requiring diagnosis shortly before its establishment. Purpose: To assess the performance of T-SPOT.TB test for the diagnosis of l
Publicado em: 2010
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10. Detecção de anticorpos IgG específicos para os antígenos ESAT-6, CFP-10, 85B, 16kDa e HBHA em pacientes com tuberculose ativa: importância no diagnóstico e efeito do tratamento quimioterápico
A detecção de anticorpos específicos pode representar um instrumento valioso no diagnóstico da tuberculose (TB). Neste trabalho níveis de anticorpos IgG contra os antígenos ESAT-6, CFP10, 85B, 16kDa e HBHA do M. tuberculosis foram avaliados em 102 amostras de soro de pacientes com TB pulmonar agrupados como: 1) pacientes com TB ativa (n=33); 2) pacient
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/06/2009
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11. Preliminary results in the immunodiagnosis of tuberculosis in children based on T cell responses to ESAT-6 and PPD antigens
The aim of this work was to study the difference in interferon gamma (IFN-gamma) production by T lymphocytes after early secretory antigen target 6 (ESAT-6) or purified protein derivate (PPD) stimulation in whole blood culture supernatants from children with suspected tuberculosis (TB) disease (n = 21), latent TB infection (n = 16) and negative controls (NC)
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-06
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12. Analysis of Cellular Immune Response Against MPT-51, GLcB, ESAT-6, Ag 85A Recombinant Antigens and the Culture Filtered Protein (CFP) from Mycobacterium tuberculosis from Patients with Active Pulmonary Tuberculosis / Análise da resposta imune celular de pacientes com tuberculose pulmonar ativa contra os antígenos recombinantes MPT-51, GLcB, ESAT-6, Ag 85A e a proteína do filtrado de cultura (CFP) de mycobacterium tuberculosis / Analysis of Cellular Immune Response Against MPT-51, GLcB, ESAT-6, Ag 85A Recombinant Antigens and the Culture Filtered Protein (CFP) from Mycobacterium tuberculosis from Patients with Active Pulmonary Tuberculosis / Análise da resposta imune celular de pacientes com tuberculose pulmonar ativa contra os antígenos recombinantes MPT-51, GLcB, ESAT-6, Ag 85A e a proteína do filtrado de cultura (CFP) de mycobacterium tuberculosis
Este trabalho avaliou a resposta imune celular dos linfócitos TCD4 e TCD8 de pacientes com tuberculose pulmonar ativa antes e após o tratamento, contra os antígenos recombinantes MPT-51, ESAT-6, GLcB, Ag85A e o Filtrado Protéico de Cultura (CFP) de Mycobacterium tuberculosis atendidos no Hospital de Doenças Tropicais Anuar Auad. A população de estudo,
Publicado em: 2008