Ethylthio
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Synthesis and Characterization of a New Unsymmetrical Potentially Pentadentate Schiff Base Ligand and Related Complexes with Manganese(II), Nickel(II), Copper(II), Zinc(II) and Cadmium(II)
New unsymmetric thioether Schiff base amine, 2-(2-aminoethylthio)-N-(thiophene-2-ylmethylene)aniline was prepared by reaction of 2-aminothiophenol with N-(2-bromoethyl)phthalimide and then by thiophene-2-carbaldehyde. Then, the phthalimide group converted to the amine by hydrazine hydrate. The new potentially pentadentate N3S2 donor unsymmetrical Schiff base
J. Braz. Chem. Soc.. Publicado em: 2017-05
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2. A New Straightforward Synthesis of 2', 3'-Didehydro-2', 3'-dideoxy-2'-(2"- (trimethylsilyl)ethylthio)thymidine, Key Intermediate for the Synthesis of 2'-Substituted Thionucleosides
We describe herein a straightforward and efficient preparation of 2',3'-dideoxy-2'-(2''- (trimethylsilyl)ethylthio)thymidine, which allows the preparation of diverse potentially antiviral and/or anticancer nucleosides (disulfides, thiols, sulfides, thiocyanates).
J. Braz. Chem. Soc.. Publicado em: 2015-04
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3. Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine
Este trabalho avalia o efeito do 2-etiltio-7-metil-4-(4-metilfenil)pirazol[1,5-a][1,3,5]triazina (MH4b1) no sistema nervoso central de camundongos ICR. O MH4b1 foi obtido por a reação de 4-metilbenzoilimidoditiocarbonato de S,S-dietil e 5-amino-3-metil-1H-pirazol em uma única etapa. O perfil neurofarmacológico foi realizado por testes de convulsão induz
Braz. J. Pharm. Sci.. Publicado em: 2014-03
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4. Reduções e oxidações eletroquímicas de cinamatos de metila ariltio e etiltio substituídos nas posições vinílicas / Electrochemicals reductions and oxidations of methyl cinnamate esters phenylthio and ethylthio substituted in vinylics positions
Este trabalho apresenta o estudo do comportamento eletroquímico de cinamatos de metila sulfenilados: o 3-feniltio-3-fenil-propenoato de metila, 2-feniltio-3-fenil-propenoato de metila, 3-fenil-3-etiltio-propenoato de metila e 2-etiltio-3-fenil-proenoato de metila. Está incluído a síntese dos substratos, a voltametria e as eletrólises preparativas, abran
Publicado em: 2008
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5. 6-(3,4-Dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile inhibits poliovirus uncoating.
We investigated the mode of action of 6-(3,4-dichlorophenoxy-3-(ethylthio)-2-pyridincarbonitrile against poliovirus. This agent effectively blocked the synthesis of poliovirus proteins and RNA when it was added at the beginning of infection. Poliovirus attachment and internalization into HeLa cells were not inhibited in the presence of the compound; poliovir
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6. Methionine recycling pathways and antimalarial drug design.
5'-Deoxy-5'-(methylthio)adenosine (MTA) is an S-adenosylmethionine metabolite that is generated as a by-product of polyamine biosynthesis. In mammalian cells, MTA undergoes a phosphorolytic cleavage catalyzed by MTA phosphorylase to produce adenine and 5-deoxy-5-(methylthio)ribose-1-phosphate (MTRP). Adenine is utilized in purine salvage pathways, and MTRP i
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7. Synthesis, deprotection, analysis and purification of RNA and ribozymes.
Improvements in the synthesis, deprotection and purification of oligoribonucleotides are described. These advances allow for reduced synthesis and deprotection times, while improving product yield. Coupling times are reduced by half using 5-ethylthio-1H-tetrazole (S-ethyltetrazole) as the activator. Base and 2'-O-t-butyldimethylsilyl deprotection with methyl
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8. Coupling of methyl coenzyme M reduction with carbon dioxide activation in extracts of Methanobacterium thermoautotrophicum.
The stimulation of carbon dioxide reduction to methane by addition of 2-(methylthio)ethanesulfonate (CH3-S-CoM) to cell extracts of Methanobacterium thermoautotrophicum was investigated. Similar stimulation of CO2 reduction by CH3-S-CoM was found for cell extracts of Methanobacterium bryantii and Methanospirillum hungatei. The CH3-S-CoM requirement could be
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9. High-pressure liquid chromatographic method for determination of Sch 29482 in human serum.
A high-pressure liquid chromatographic method was developed for quantitative determination in human serum of a new penem antibiotic known as Sch 29482 (5R,6S,8R-2-ethylthio-6(1-hydroxyethyl)penem-3-carboxylic acid). The method involves serum extraction at an acid pH with ether, followed by separation on a reverse-phase column and UV light detection at 254 nm
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10. Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles.
The entry of animal viruses into cells is associated with permeabilization of the infected cells to protein toxins such as alpha-sarcin (C. Fernández-Puentes and L. Carrasco, Cell 20:769-775, 1980). This phenomenon has been referred to as "the early permeabilization by animal viruses" (L. Carrasco, Virology 113:623-629, 1981). A number of inhibitors of poli
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11. In Vitro Antiviral Activity of 6-Substituted 9-β-d-Ribofuranosylpurine 3′,5′-Cyclic Phosphates
A series of twelve recently synthesized 6-substituted derivatives of 9-β-d-ribofuranosylpurine 3′,5′-cyclic phosphate (RPcMP) were evaluated for in vitro antiviral activity, using inhibition of viral cytopathogenic effect as the primary parameter for evaluation. Inhibition of the development of intra- and extracellular virus titer was used as a secondar
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12. In vitro and in vivo antipicornavirus activity of some phenoxypyridinecarbonitriles.
Nineteen phenoxypyridinecarbonitriles were initially evaluated for their in vitro activity against rhinoviruses (RV) 1A, 2, and 64 and coxsackievirus (Cox) A21 and for their oral prophylactic and therapeutic activity in Swiss albino mice challenged with Cox A21. On the basis of the results of these studies, one compound, 6-(3,4-dichlorophenoxy)-3-(ethylthio)