Exosomes
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats
Exosomes, a kind of extracellular vesicle, are promising therapeutic agents for spinal cord injury (SCI). This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b or negative control (miR NC). SCI rats were injected i
Braz J Med Biol Res. Publicado em: 05/12/2019
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2. Exosomes as Biomarker of Cancer
ABSTRACT Rapid advances in medicine and biotechnology resulted in the development of non-invasive diagnostic and prognostic biomarkers enabling convenient and accurate detection. Exosomes has recently emerged as non-invasive biomarker for a number of diseases including cancer. Exosomes are the small endosome originated membranous vesicles secreted in a numbe
Braz. arch. biol. technol.. Publicado em: 08/10/2018
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3. Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including tumor invasion, metastasis, and drug resistance. In this stu
Braz J Med Biol Res. Publicado em: 13/11/2017
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4. microRNAs and the mammary gland: a new understanding of gene expression
MicroRNAs (miRNAs) have been identified in cells as well as in exosomes in biological fluids such as milk. In mammary gland, most of the miRNAs studied have functions related to immunity and show alterations in their pattern of expression during lactation. In mastitis, the inflammatory response caused by Streptococcus uberis alters the expression of miRNAs t
Genet. Mol. Biol.. Publicado em: 25/10/2013
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5. Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm
Braz J Med Biol Res. Publicado em: 02/10/2013
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6. Exossomos derivados de células dendríticas como adjuvantes naturais na resposta antitumoral. / Dendritic cells-derived exosomes as natural adjuvants in antitumor responses.
Exossomos (Exo) originados de células dendríticas (DCs) carregam moléculas associadas à apresentação antigênica. Neste trabalho procurou-se estabelecer se Exo de DCs seriam capazes de conferir imunogenicidade às células tumorais. Os Exo isolados de culturas de DCs expressavam as moléculas HLA-ABC, HLA-DR, CD86, CD11c, CD81, CD54 e CD18. Estes foram
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/05/2012
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7. Geração de espécies reativas por exossomos plaquetários: um possível novo mecanismo de disfunção vascular na sepse / Generation of reactive oxygen species by platelet-derived exosomes: a possible novel mechanism of vascular dysfunction in sepsis
Sepsis, the bodys response to infection, is associated with high mortality rates. Why a protective mechanism turns into a deadly clinical picture is a matter of debate, and goes largely unexplained. In previous work we demonstrated that plateled derived exosomes are found in the plasma of septic patients with septic shock and can induce endothelial and vascu
Publicado em: 2009
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8. Proteomic and immunologic analyses of brain tumor exosomes
Brain tumors are horrific diseases with almost universally fatal outcomes; new therapeutics are desperately needed and will come from improved understandings of glioma biology. Exosomes are endosomally derived 30–100 nm membranous vesicles released from many cell types into the extracellular milieu; surprisingly, exosomes are virtually unstudied in neuro-o
The Federation of American Societies for Experimental Biology.
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9. Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patie
Nature Publishing Group.
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10. Toxoplasma gondii Antigen-Pulsed-Dendritic Cell-Derived Exosomes Induce a Protective Immune Response against T. gondii Infection
It was previously demonstrated that immunizing mice with spleen dendritic cells (DCs) that had been pulsed ex vivo with Toxoplasma gondii antigens triggers a systemic Th1-biased specific immune response and induces protection against infection. T. gondii can cause severe sequelae in the fetuses of mothers who acquire the infection during pregnancy, as well a
American Society for Microbiology.
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11. Cells release prions in association with exosomes
Prion diseases are infectious neurodegenerative disorders linked to the accumulation in the central nervous system of the abnormally folded prion protein (PrP) scrapie (PrPsc), which is thought to be the infectious agent. Once present, PrPsc catalyzes the conversion of naturally occurring cellular PrP (PrPc) to PrPsc. Prion infection is usually initiated in
National Academy of Sciences.
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12. The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume
Aquaporin-1 (AQP-1), the universal water channel, is responsible for rapid response of cell volume to changes in plasma tonicity. In the membrane of the red cell the concentration of the protein is tightly controlled. Here, we show that AQP-1 is partially lost during in vitro maturation of mouse reticulocytes and that it is associated with exosomes, released
American Society of Hematology.