Expressao Dicistronica
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1. Clonagem e expressão da glucocerebrosidase humana em células de ovário de hamster chinês (CHO). / Cloning and expression of human glucocerebrosidase in Chinese hamster ovary (CHO) cells.
Deficiency of the lysosomal glucocerebrosidase (GCR) enzyme results in Gauchers disease. Current treatment consists on enzyme replacement therapy by the administration of recombinant GCR produced in CHO cells. However, the medicine available in the market is extremely expensive. In this work, we proposed the cloning and expression of human GCR in CHO cells,
Publicado em: 2010