Extracellular Matrix Modulation
Mostrando 1-12 de 60 artigos, teses e dissertações.
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1. Tratamento com inibidor da Rho quinase em cobais com inflamação pulmonar alérgica crônica: modulação da inflamação eosinofílica, da expressão de citocinas inflamatórias, da matriz extracelular e do estresse oxidativo no parênquima pulmonar / Treatment with Rho-kinase inhibitor in guinea pigs with chronic allergic inflammation: modulation of eosinophilic inflammation, expression of inflammatory cytokines, extracellular matrix and oxidative stress in lung tissue
RATIONALE: Previous studies with Rho-kinase inhibitors suggest a beneficial influence of these drugs in asthma. The relevance of distal lung tissue in functional asthmatic impairment has been intensely emphasized. There have not been any previous studies evaluating the effects of these inhibitors on the modulation of distal lung mechanics and histopathologic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2012
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2. Modulação da expressão dos componentes da matriz extracelular e a modulação celular na regeneração da fratura óssea padronizada em tíbia de ratos / Modulação da expressão dos componentes da matriz extracelular e a modulação celular na regeneração da fratura óssea padronizada em tíbia de ratos / Modulation of expression extracellular matrix components and the cell modulation in regeneration of fracture bone standardized in the tibia of rats / Modulation of expression extracellular matrix components and the cell modulation in regeneration of fracture bone standardized in the tibia of rats
O propósito do presente trabalho foi investigar a participação da proliferação celular e da expressão dos componentes da matriz extracelular na cascata de eventos do processo de reparo da fratura óssea, empregando as técnicas histológica, imunohistoquímica e morfométrica, em um modelo experimental padronizado para a indução da lesão na tíbia d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/08/2012
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3. Imunoproteção de ilhotas pancreáticas microencapsuladas em biomateriais inovadores e seu potencial terapêutico no diabetes mellitus tipo 1 / Immunoprotection of pancreatic islets microencapsulated in inovative biomaterials and its therapeutic potential in type 1 Diabetes Mellitus
Transplantation of microencapsulated islets represents an attractive therapeutical approach to treat type 1 Diabetes Mellitus, accounting for an improved glycemic control and the abolishment of immunosuppressive therapies. However, maintenance of long-term β-cell viability remains a major problem. During islet isolation, the loss of extracellular matrix
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/05/2012
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4. Tratamento com inibidor da Rho quinase em cobaias com inflamação alérgica crônica: modulação da inflamação eosinofílica, da expressão de citocinas inflamatórias, da matriz extracelular, do estresse oxidativo e da reatividade de vias aéreas / Treatment with Rho-kinase inhibitor in guinea pigs with chronic allergic inflammation: modulation of eosinophilic inflammation, expression of inflammatory cytokines, extracellular matrix, oxidative stress and airway responsiveness
INTRODUÇÃO: Vários estudos têm mostrado a importância da Rho quinase na modulação da contração do músculo liso, hiperresponsividade das vias aéreas e inflamação. Entretanto, os efeitos do tratamento crônico com um inibidor específico desta via não haviam sido previamente investigados. MÉTODOS: No presente estudo, foram avaliados os efeitos d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/04/2012
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5. The infection of microvascular endothelial cells with ExoU-producing Pseudomonas aeruginosa triggers the release of von Willebrand factor and platelet adhesion
An increased plasma concentration of von Willebrand factor (vWF) is detected in individuals with many infectious diseases and is accepted as a marker of endothelium activation and prothrombotic condition. To determine whether ExoU, a Pseudomonas aeruginosa cytotoxin with proinflammatory activity, enhances the release of vWF, microvascular endothelial cells w
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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6. Participação do L-NAME, da L-arginina e da N-acetilcisteína no enfisema pulmonar induzido por fumaça de cigarro em camundongos / The lung remodeling in mouse emphysema is independent of nitric oxide modulation
Nitric oxide (NO) represents one of the most important intra and extracellular mediators/messengers. It takes part in both biologic and pathologic processes. This study aimed to verify NO role in pulmonary emphysema induced by cigarette smoke (CS) in mice. So L-NAME (LN) (a NOinhibitor) and L-arginine (LA) (a substract for NO formatio
Publicado em: 2010
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7. Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat
Nutritional substances associated to some hormones enhance liver regeneration when injected intraperitoneally, being denominated hepatotrophic factors (HF). Here we verified if a solution of HF (glucose, vitamins, salts, amino acids, glucagon, insulin, and triiodothyronine) can revert liver cirrhosis and how some extracellular matrices are affected. Cirrhosi
Brazilian Journal of Medical and Biological Research. Publicado em: 25/09/2009
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8. Flavins promote changes in the extracellular matrix, signal transduction, antioxidant enzymes and metalloproteinases during osteoblast differentiation / Flavinas promovem mudanças na matriz extracelular, vias de transdução de sinal, enzimas antioxidantes e metaloproteinases durante a diferenciação de osteoblastos
Riboflavin (Rb-Vitamin B2) is the precursor of essential flavocoenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes participate in numerous enzymatic processes dependent on electron transfer reactions that occur in energyproducing, biosynthetic, and detoxifying and electron-scavenging pathways. Increase dietary ribofla
Publicado em: 2009
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9. O estresse físico modula a mecânica de tecido pulmonar periférico, a expressão de citocinas e o estresse oxidativo em cobaias com inflamação alérgica crônica / Physical stress modulates lung tissue mechanics, cytokines and oxidative stress activation in guinea pigs with chronic allergic inflammation
There are evidences showing that stress can worsen asthma symptoms, but the exact mechanisms that link them are not clarified, especially in the distal lung parenchyma. Recently, the importance of the lung parenchyma has been emphasized in the modulations of the functional alterations, inflammatory and remodeling that characterizes asthma. These alterations
Publicado em: 2009
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10. Mecanismos de transdução de sinal envolvidos com a diferenciação de osteoblastos e osteocitos / Signal transduction activated during differentiation of osteoblsts and osteocytes
The main goal of this work was to investigate the signal transduction pathways triggered during the bone cells differentiation. In this way, several molecular aspects of this process were analyzed. Src kinase modulation by the low molecular weight protein tyrosine phosphatase (LMWPTP) was essential for the occurrence of the differentiation induced by ascorbi
Publicado em: 2008
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11. Detection of metalloproteinases of the gelatinases family and their inhibitors in the interpubic ligament of the mouse, during pregnancy / Detecção de metaloproteinases da familia das gelatinases e de seus inibidores no ligamento interpubico do camundongo, durante a prenhez
During pregnancy of some rodents a deep remodeling occurs in the pubic symphysis (PS). In the mouse, these fibrocartilagenousarticulation are gradually replaced by a dense connective tissue, forming the interpubic ligament (IL) at the end of pregnancy. Right after birth, this ligament is rapidly remodeled and the space between the two bones is quickly closed
Publicado em: 2007
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12. Expressão temporal e espacial de RECK, metaloproteinase-2 e metaloproteinase-9 durante a palatogenese em camundongos / Temporal and spatial expression of RECK, metalloproteinase-2 and metalloproteinase-9 during palatogenesis in mice
The oral clefts show a great influence in the size of their hosts. They have, since birthy, difficulties in alimentation, problems in the maxilar bones, in dental arch, in speech, and in some cases, in hearing. In addition, the hosts and their families have serious psychological problems due to the esthetic lenght caused by anomalia. With no doubt, the forma
Publicado em: 2007