Fatty Acid Synthesis Inhibitors
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. Insilico Analysis of Phytoconstituents from Allium sativum as Potential Inhibitors of Inha in Mycobacterium tuberculosis
ABSTRACT Tuberculosis is leading cause of death among the global bacterial infections. The main causative for tuberculosis is Mycobacterium tuberculosis, which will survive in its host human being for decades in latent or chronic levels. In addition, the late multidrug resistance at a disturbing rate accompanies the appearance of tuberculosis. The quick spre
Braz. arch. biol. technol.. Publicado em: 27/06/2016
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2. Estudo do papel biológico da enzima ácido graxo sintase (FASN) em células endoteliais derivadas dos vasos sanguíneos / Study of the biological role of the enzyme fatty acid synthase (FASN) in endothelial cells derived from blood vessels
Fatty acid synthase (FASN) is the anabolic enzyme with high expression and activity in several human malignancies, which is responsible for the endogenous synthesis of saturated fatty acids and consequently of the phospholipids present in cell membranes. Inhibition of FASN with orlistat (Xenical), an anti-obesity drug, is described as having anti-neoplastic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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3. Avaliação da morte celular induzida por inibidores da enzima acido graxo sintase em linhagem celular derivada de melanoblastos não tumorigenicos de camundongos / Non-tumorigenic melanocyte cell death induced by fatty acid synthase inhibitors
Ácido graxo sintase (FASN - EC 2.3.1.85) é a enzima responsável pela síntese endógena de ácidos graxos de cadeia longa a partir dos precursores acetil-CoA e malonil-CoA. Diversos estudos mostram que a FASN é altamente expressa em vários tipos de neoplasias malignas humanas, tais como de próstata, mama, melanoma e, em alguns destes tumores, a alta ex
Publicado em: 2010
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4. Proteção por L-carnitina ou piracetam contra a morte celular causada por sinvastatina em celulas tumorais e não tumorais / Protection by L-carnitine or piracetam against cell death caused by simvastatin in tumor and non tumorigenic cell lines
Statins are drugs widely used in the treatment of hypercholesterolemia. They are competitive inhibitors of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase preventing in this way, the synthesis of cholesterol. L-carnitine is synthesized from the essential aminoacids lysine and methionine in liver and kidney and plays na important role in the cell, w
Publicado em: 2010
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5. A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum
It has long been held that the malaria parasite, Plasmodium sp., is incapable of de novo fatty acid synthesis. This view has recently been overturned with the emergence of data for the presence of a fatty acid biosynthetic pathway in the relict plastid of P. falciparum (known as the apicoplast). This pathway represents the type II pathway common to plant chl
American Society for Microbiology.
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6. Inhibition of fatty acid synthesis in Escherichia coli in the absence of phospholipid synthesis and release of inhibition by thioesterase action.
The effects of inhibition of Escherichia coli phospholipid synthesis on the accumulation of intermediates of the fatty acid synthetic pathway have been previously investigated with conflicting results. We report construction of an E. coli strain that allows valid [14C]acetate labeling of fatty acids under these conditions. In this strain, acetate is a specif
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7. 13C nuclear magnetic resonance studies of Pseudomonas putida fatty acid metabolic routes involved in poly(3-hydroxyalkanoate) synthesis.
The formation of poly(3-hydroxyalkanoates) (PHAs) in Pseudomonas putida KT2442 from various carbon sources was studied by 13C nuclear magnetic resonance spectroscopy, gas chromatography, and gas chromatography-mass spectroscopy. By using [1-13C]decanoate, the relation between beta-oxidation and PHA formation was confirmed. The labeling pattern in PHAs synthe
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8. In Vivo Evidence that S-Adenosylmethionine and Fatty Acid Synthesis Intermediates Are the Substrates for the LuxI Family of Autoinducer Synthases
Many gram-negative bacteria synthesize N-acyl homoserine lactone autoinducer molecules as quorum-sensing signals which act as cell density-dependent regulators of gene expression. We have investigated the in vivo source of the acyl chain and homoserine lactone components of the autoinducer synthesized by the LuxI homolog, TraI. In Escherichia coli, synthesis
American Society for Microbiology.
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9. Alteration of the specificity and regulation of fatty acid synthesis of Escherichia coli by expression of a plant medium-chain acyl-acyl carrier protein thioesterase.
The expression of a plant (Umbellularia californica) medium-chain acyl-acyl carrier protein (ACP) thioesterase (BTE) cDNA in Escherichia coli results in a very high level of extractable medium-chain-specific hydrolytic activity but causes only a minor accumulation of medium-chain fatty acids. BTE's full impact on the bacterial fatty acid synthase is apparent
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10. Identification and Characterization of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase
Bacterial enoyl-acyl carrier protein reductase (ENR) catalyzes an essential step in fatty acid biosynthesis. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization a
American Society for Microbiology.
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11. Effects of metabolic inhibitors on extracellular fructosyltransferase production in Actinomyces viscosus.
Extracellular fructosyltransferase (levansucrase; EC 2.4.1.10) production in Actinomyces viscosus T14AV was demonstrated to occur concomitantly with cellular growth. The inhibition of both cellular ribonucleic acid and protein synthesis resulted in no further accumulation of enzyme activity. The antibiotic sodium clofibrate differentially inhibited the produ
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12. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol deprivation and insulin elevation, respectively. This regulatory mechanism underlies the adaptation to cholesterol synthesis inhibitors (statins) and high calorie diets (insulin). In nonhepatic cells, lipid synthesis is controlled by sterol regulatory element-binding
Cold Spring Harbor Laboratory Press.