Fe Overload
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-
Braz J Med Biol Res. Publicado em: 19/10/2017
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2. Efeito do Butirato de sódio sobre o déficit de memória induzido pela sobrecarga neonatal com ferro
Iron accumulation in the brain has been associated to the pathogenesis of neurodegenerative disorders. We have previously demonstrated that iron overload in the neonatal period results in severe and persistent memory deficits in adult rats. Here, using the animal model of cognitive impairment induced by iron overload we tested the effects of NaBut in amelior
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/03/2011
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3. Sobrecarga de ferro em ratos sadios / Iron overload in healthy rats
O objetivo do presente trabalho foi investigar o efeito de diferentes concentrações dietéticas de Fe em parâmetros sangüíneos (hemograma, perfil lipídico) e hepáticos (concentração de minerais, perfil de ácidos graxos, apoptose) de ratos sadios. Depósitos de Fe no baço e medula óssea também foram avaliados por análises histológicas. Ratos Wi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/02/2011
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4. Role of ferritin in the rice tolerance to iron overload
Deficiência de ferro (Fe) ocorre freqüentemente em plantas, uma vez que este mineral é pouco disponível em condições aeróbicas. Plantas de arroz cultivadas sob alagamento, no entanto, estão sujeitas ao excesso de Fe, que pode ser extremamente tóxico. Alguns cultivares de arroz são resistentes a altas concentrações de ferro, mas os mecanismos fisi
Publicado em: 2010
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5. A sobrecarga aguda cardÃaca advinda de fÃstula aorto-caval retarda o esvaziamento gÃstrico de lÃquidos em ratos acordados. / The overload acute cardiac after aortocaval fistula delays the gastric emptying of liquids in awake rats.
Tendo em vista que o comportamento motor do trato gastrointestinal parece ter intima relaÃÃo com a atividade do sistema cardiovascular, decidimos verificar se a redistribuiÃÃo do volume sanguÃneo atravÃs de fistula aorto-caval com agulhas de calibres (21, 23 ou 26G) afeta a motilidade do trato gastrintestinal em ratos acordados. Ratos machos albinos (2
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2008
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6. Validação de uma bicicleta ergométrica de ciclismo indoor
The adaptation of load system an bicycle ergometer for indoor cycling (BEIC) allowed its classification as an cycle ergometer, however, its validation must be tested. Because of this it was decided to test the validation of BEIC and the contested Monark. Forty and two cyclists of a regional level (Mean-DP): age 33,7 (8,4) years; stature 175,3 (6,3) cm; body
Publicado em: 2008
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7. Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate
It has been suggested that iron overload may be carcinogenic. In the present study, we evaluated the effect of plasma and prostate carotenoid concentration on oxidative DNA damage in 12-week-old Wistar rats treated with intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) (10 mg Fe/kg). Plasma ß-carotene and lycopene concentrations were measured as a func
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-02
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8. "Um biossusceptômetro supercondutor AC para quantificar o ferro hepático". / A Superconductor AC Susceptometer to Quantify Liver Iron.
This work consisted in the development of a system to measure the magnetization of large paramagnetic and diamagnetic samples. The main application was susceptometric measurements of the hepatic tissue for quantification of the iron overload. Iron excess is commonly observed in thalassemic and sickle cell anemia patients who have repeatedly received red bloo
Publicado em: 2001
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9. Hepatic lipid peroxidation in vivo in rats with chronic iron overload.
Peroxidative decomposition of cellular membrane lipids is a postulated mechanism of hepatocellular injury in parenchymal iron overload. In the present study, we looked for direct evidence of lipid peroxidation in vivo (as measured by lipid-conjugated diene formation in hepatic organelle membranes) from rats with experimental chronic iron overload. Both paren
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10. Iron-Regulated Expression of a Cytosolic Ascorbate Peroxidase Encoded by the APX1 Gene in Arabidopsis Seedlings
Iron (Fe) is an essential element for living organisms. However, under aerobic conditions, its use is complicated because of its high insolubility and its potential toxicity through reactivity with reduced forms of oxygen. In plants, Fe overload can lead to intracellular concentrations beyond the storage and detoxification capacities of cells. Such a displac
The American Society for Plant Biologists.
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11. beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.
Hemochromatosis (HC) is an inherited disorder of iron absorption, mapping within the human major histocompatibility complex (MHC). We have identified a multigene system in the murine MHC that contains excellent candidates for the murine equivalent of the human HC locus and implicate nonclassical class I genes in the control of iron absorption. This gene syst
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12. Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states.
In hemochromatosis and other disorders associated with iron overload, a significant fraction of the total iron in plasma circulates in the form of low molecular weight complexes not bound to transferrin. Efficient and unregulated clearance of this form of iron by the liver may account for the hepatic iron loading and toxicity that characterize these diseases