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1. Analysis of genomic sequence features related to alternative splicing events (intron retention) in the human transcriptome / Análise de características das seqüencias genômicas relacionadas a eventos de splicing alternativo do tipo retenção de intron no transcriptoma humano
Most eukaryotic genes are split in exons and introns, requiring mRNA processing to remove intervening sequences and join exons (splicing). Exon/intron borders are defined by splice sites that are normally recognized with high fidelity, yielding the same processed mRNA each time. Notwithstanding such precise recognition, alternative joining of exons has been
Publicado em: 2007